(R)-4-nonanol | 102339-97-9

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: (R)-4-nonanol
• 英文别名: (4R)-nonan-4-ol
• CAS: 102339-97-9
• 化学式: C₉H₂₀O
• 分子量: 144.257
• InChiKey: IXUOEGRSQCCEHB-SECBINFHSA-N

物化性质

• 沸点：
  192.5±0.0 °C(Predicted)
• 密度：
  0.824±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  10
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  (2E)-non-2-en-4-one 在 2.)10percentPd-C 氢气 作用下， 生成 (R)-4-nonanol
  参考文献：
  名称：

  从二芳基庚烷在不同性质的溶剂中的旋光角度来看，主导逆转的因素

  摘要：

  导致 (s)-1,7-diphenyl-5-hydroxy-3-heptanone 在氯仿中右旋的原因是 C-3 羰基和 C-5 羟基之间形成分子内氢键，无论是否存在苯基。另一方面，证明化合物在甲醇中左旋需要同时破坏分子内氢键，然后溶剂化到其 β-酮醇部分，以及苯基的存在。

  DOI：

  10.1246/cl.1985.1331

文献信息

• Prostacyclin compounds, compositions and methods of use thereof
  申请人：Insmed Incorporated

  公开号：US10010518B2

  公开（公告）日：2018-07-03

  Prostacyclin compounds and compositions comprising the same are provided herein. Specifically, prostacyclin compounds comprising treprostinil covalently linked to a linear C5-C18 alkyl, branched C5-C18 alkyl, linear C2-C18 alkenyl, branched C3-C18 alkenyl, aryl, aryl-C1-C18 alkyl or an amino acid or a peptide (e.g., dipeptide, tripeptide, tetrapeptide) are described. The linkage, in one embodiment, is via a carbamate, amide or ester bond. Prostacyclin compounds provided herein can also include at least one hydrogen atom substituted with at least one deuterium atom. Methods for treating pulmonary hypertension (e.g., pulmonary arterial hypertension) and portopulmonary hypertension are also provided.

  本文提供了前列环素化合物和包含前列环素化合物的组合物。具体而言，描述了前列环素化合物，该化合物包含与线性 C5-C18 烷基、支链 C5-C18 烷基、线性 C2-C18 烯基、支链 C3-C18 烯基、芳基、芳基-C1-C18 烷基或氨基酸或肽（如二肽、三肽、四肽）共价连接的曲普瑞替尼。在一个实施方案中，连接是通过氨基甲酸酯、酰胺或酯键。本文提供的前列环素化合物还可以包括至少一个被至少一个氘原子取代的氢原子。还提供了治疗肺动脉高压（如肺动脉高压）和门肺动脉高压的方法。
• Chiral allenylboronic esters: a practical reagent for enantioselective carbon-carbon bond formation
  作者：Ryuichi Haruta、Masaharu Ishiguro、Nobuo Ikeda、Hisashi Yamamoto

  DOI：10.1021/ja00390a052

  日期：1982.12
• PROSTACYCLIN COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF
  申请人：Insmed Incorporated

  公开号：US20150148414A1

  公开（公告）日：2015-05-28

  Prostacyclin compounds and compositions comprising the same are provided herein. Specifically, prostacyclin compounds comprising treprostinil covalently linked to a linear C 5 -C 18 alkyl, branched C 5 -C 18 alkyl, linear C 2 -C 18 alkenyl, branched C 3 -C 18 alkenyl, aryl, aryl-C 1 -C 18 alkyl or an amino acid or a peptide (e.g., dipeptide, tripeptide, tetrapeptide) are described. The linkage, in one embodiment, is via a carbamate, amide or ester bond. Prostacyclin compounds provided herein can also include at least one hydrogen atom substituted with at least one deuterium atom. Methods for treating pulmonary hypertension (e.g., pulmonary arterial hypertension) and portopulmonary hypertension are also provided.
• Prostacyclin Compounds, Compositions and Methods of use Thereof
  申请人：Insmed Incorporated

  公开号：US20160256425A1

  公开（公告）日：2016-09-08

  Prostacyclin compounds and compositions comprising the same are provided herein. Specifically, prostacyclin compounds comprising treprostinil covalently linked to a linear C 5 -C 18 alkyl, branched C 5 -C 18 alkyl, linear C 2 -C 18 alkenyl, branched C 3 -C 18 alkenyl, aryl, aryl-C 1 -C 18 alkyl or an amino acid or a peptide (e.g., dipeptide, tripeptide, tetrapeptide) are described. The linkage, in one embodiment, is via a carbamate, amide or ester bond. Prostacyclin compounds provided herein can also include at least one hydrogen atom substituted with at least one deuterium atom. Methods for treating pulmonary hypertension (e.g., pulmonary arterial hypertension) and portopulmonary hypertension are also provided.
• METHOD FOR PRODUCING OXO FATTY ACID AND RARE FATTY ACID
  申请人：KYOTO UNIVERSITY

  公开号：US20170335355A1

  公开（公告）日：2017-11-23

  The present invention provides a production method of oxo fatty acid, as well as rare fatty acids such as conjugated fatty acid, hydroxylated fatty acid, partially saturated fatty acid and the like, which uses 4 kinds of enzymes (fatty acid-hydratase, hydroxylated fatty acid-dehydrogenase, oxo fatty acid-isomerase, oxo fatty acid-enone reductase) derived from Lactobacillus plantarum including lactic acid bacteria and the like. Furthermore, the present invention also provides a more efficient production method of oxo fatty acid and the like, which partly uses a chemical oxidation reaction in combination.