The compound with the structure (2) elucidated for patellamide B was synthesized and found to be not identical with that cyclopeptide. A new proposition for the structure of patellamide B is given.
New methods and reagents in organic synthesis. 55. Total syntheses of patellamides B and C, cytotoxic cyclic peptides from a tunicate 1. Their proposed structures should be corrected.
Patellamides B and C, cytotoxic lipophilic cyclic peptides from a marine tunicate, with proposed structures have been synthesized by the use of diphenyl phosphorazidate(DPPA) and diethyl phosphorocyanidate(DEPC). Their physicochemical properties lead to reassign the structures of patellamides B and C on the bonding order.