8-acetyl-6-hydroxy-7-methoxycoumarin | 202288-19-5

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 香豆素及其衍生物
• 英文名称: 8-acetyl-6-hydroxy-7-methoxycoumarin
• 英文别名: 8-acetyl-6-hydroxy-7-methoxy-coumarin；8-Acetyl-6-hydroxy-7-methoxy-cumarin；8-acetyl-6-hydroxy-7-methoxychromen-2-one
• CAS: 202288-19-5
• 化学式: C₁₂H₁₀O₅
• 分子量: 234.208
• InChiKey: KSUVXYKSJLPCAO-UHFFFAOYSA-N

物化性质

• 熔点：
  196-197 °C(Solv: ethanol (64-17-5))
• 沸点：
  489.7±45.0 °C(Predicted)
• 密度：
  1.369±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  72.8
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  8-acetyl-6-hydroxy-7-methoxycoumarin 在 sodium hydroxide 、 硫酸 、 双氧水 、 potassium carbonate 、 丙酮 作用下， 生成 秦皮素
  参考文献：
  名称：

  黄酮和相关化合物的核氧化。第XLVII部分。Fraaxetin的新合成方法和4-methylfraxetin的合成方法

  摘要：

  DOI：

  10.1039/jr9540003065
• 作为产物：
  描述：

  8-乙酰-7-甲氧基香豆素 在 氢氧化钾 作用下， 生成 8-acetyl-6-hydroxy-7-methoxycoumarin
  参考文献：
  名称：

  黄酮和相关化合物的核氧化。第XLVII部分。Fraaxetin的新合成方法和4-methylfraxetin的合成方法

  摘要：

  DOI：

  10.1039/jr9540003065

文献信息

• Mazur, Jolanta; Zawadowski, Teodor, Acta poloniae pharmaceutica, 1997, vol. 54, # 5, p. 371 - 374
  作者：Mazur, Jolanta、Zawadowski, Teodor

  DOI：——

  日期：——
• Compounds exhibiting efflux inhibitor activity and composition and uses thereof
  申请人：Wempe Fitzpatrick Michael

  公开号：US20070254859A1

  公开（公告）日：2007-11-01

  At least one compound chosen from compounds of Formula I: a pharmaceutically acceptable salt or ester thereof, a solvate thereof, a chelate thereof, a non-covalent complex thereof, a prodrug thereof, and mixtures of any of the foregoing, wherein: n is a number from 1 to 900, wherein the individual units may be the same or different; W is chosen from alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, aryl, substituted aryl, aralkyl and substituted aralkyl; each of R 2 , R 3 , R 4 and R 5 is independently chosen from —H, alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, aryl, substituted aryl, aralkyl and substituted aralkyl; Z′ is chosen from —O—, —N—, —NO—, —NR 4 —, —S—, —SO— and —SO 2 —, wherein R 4 is defined as above; each of X, X′, Y and Z is independently chosen from —CR 4 R 5 —, —NH—, —NR 4 —, —NO—, —O—, —NOR 4 —, —S—, —SO—, —SO 2 —, wherein R 4 and R 5 are defined as above; R 1 is chosen from a tocopherol, a steroid and a flavonoid; and R 6 is chosen from any R 1 , alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, aryl, substituted aryl, aralkyl and substituted aralkyl.
• NOX INHIBITOR AND NFkB INHIBITOR CONTAINING METHOXYFLAVONE
  申请人：SUNTORY HOLDINGS LIMITED

  公开号：US20170071902A1

  公开（公告）日：2017-03-16

  The present invention aims at providing NOX inhibitors and NFκB inhibitors having superior actions, as well as agents for preventing or treating NOX- or NFκB-associated diseases that utilize such inhibitors. To this end, specified methoxyflavones are employed.
• Nuclear oxidation in flavones and related compounds. Part XLVII. A new synthesis of fraxetin and a synthesis of 4-methylfraxetin
  作者：K. Aghoramurthy、T. R. Seshadri

  DOI：10.1039/jr9540003065

  日期：——