benzyl (S)-2-(2-((tert-butyldiphenylsilyl)oxy)acetoxy)propanoate | 1043023-98-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: benzyl (S)-2-(2-((tert-butyldiphenylsilyl)oxy)acetoxy)propanoate
• CAS: 1043023-98-8
• 化学式: C₂₈H₃₂O₅Si
• 分子量: 476.645
• InChiKey: HNUXBZYHDUBGMK-QFIPXVFZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.24
• 重原子数：
  34.0
• 可旋转键数：
  9.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  61.83
• 氢给体数：
  0.0
• 氢受体数：
  5.0

反应信息

• 作为反应物：
  描述：

  benzyl (S)-2-(2-((tert-butyldiphenylsilyl)oxy)acetoxy)propanoate 在 palladium on activated charcoal 、 氢气 作用下， 以 乙酸乙酯 为溶剂， 反应 20.0h， 以97.6%的产率得到(2S)-2-[2-[tert-butyl(diphenyl)silyl]oxyacetyl]oxypropanoic acid
  参考文献：
  名称：

  一种治疗胰腺癌的环糊精衍生物包合物

  摘要：

  本发明涉及一种治疗胰腺癌的环糊精衍生物包合物，所述包合物中两种活性成分的存在方式不同，其中吉西他滨先以化学键合的方式连接于β‑环糊精衍生物上，再用该β‑环糊精衍生物进一步包合厄洛替尼形成载药包合物。与常规环糊精包合物相比，本发明的β‑环糊精衍生物包合物可在体内持续释放厄洛替尼和吉西他滨，使两者在血液中长时间维持在有效作用浓度范围内。因此，该β‑环糊精衍生物包合物可显著提高联合用药的疗效，并产生难以预期的优异效果。

  公开号：

  CN107854694B
• 作为产物：
  描述：

  溴甲苯 在 4-二甲氨基吡啶 、 caesium carbonate 、 N,N'-二环己基碳二亚胺 作用下， 以 甲醇 、 二氯甲烷 、 水 为溶剂， 反应 26.5h， 生成 benzyl (S)-2-(2-((tert-butyldiphenylsilyl)oxy)acetoxy)propanoate
  参考文献：
  名称：

  一种治疗胰腺癌的环糊精衍生物包合物

  摘要：

  本发明涉及一种治疗胰腺癌的环糊精衍生物包合物，所述包合物中两种活性成分的存在方式不同，其中吉西他滨先以化学键合的方式连接于β‑环糊精衍生物上，再用该β‑环糊精衍生物进一步包合厄洛替尼形成载药包合物。与常规环糊精包合物相比，本发明的β‑环糊精衍生物包合物可在体内持续释放厄洛替尼和吉西他滨，使两者在血液中长时间维持在有效作用浓度范围内。因此，该β‑环糊精衍生物包合物可显著提高联合用药的疗效，并产生难以预期的优异效果。

  公开号：

  CN107854694B

文献信息

• New Insights into Poly(lactic-<i>co</i>-glycolic acid) Microstructure: Using Repeating Sequence Copolymers To Decipher Complex NMR and Thermal Behavior
  作者：Ryan M. Stayshich、Tara Y. Meyer

  DOI：10.1021/ja102670n

  日期：2010.8.11

  Sequence, which Nature uses to spectacular advantage, has not been fully exploited in synthetic copolymers. To investigate the effect of sequence and stereosequence on the physical properties of copolymers, a family of complex isotactic, syndiotactic, and atactic repeating sequence poly(lactic-co-glycolic acid) copolymers (RSC PLGAs) were prepared and their NMR and thermal behavior was studied. The unique suitability of polymers prepared from the bioassimilable lactic and glycolic acid monomers for biomedical applications makes them ideal candidates for this type of sequence engineering. Polymers with repeating units of LG, GLG and LLG (L = lactic, G = glycolic) with controlled and varied tacticities were synthesized by assembly of sequence-specific, stereopure dimeric, trimeric, and hexameric segmer units. Specifically labeled deuterated lactic and glycolic acid segmers were likewise prepared and polymerized. Molecular weights for the copolymers were in the range M-n = 12-40 kDa by size exclusion chromatography in THF. Although the effects of sequence-influenced solution conformation were visible in all resonances of the H-1 and C-13 NMR spectra, the diastereotopic methylene resonances in the H-1 NMR (CDCl3) for the glycolic units of the copolymers proved most sensitive. An octad level of resolution, which corresponds to an astounding 31-atom distance between the most separated stereocenters, was observed in some mixed sequence polymers. Importantly, the level of sensitivity of a particular NMR resonance to small differences in sequence was found to depend on the sequence itself. Thermal properties were also correlated with sequence.