(-)-N-Acetyl-S-α-methyl-phenylalanin | 14603-97-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (-)-N-Acetyl-S-α-methyl-phenylalanin
• 英文别名: (2S)-2-acetamido-2-methyl-3-phenylpropanoic acid
• CAS: 14603-97-5
• 化学式: C₁₂H₁₅NO₃
• 分子量: 221.256
• InChiKey: JOEYNSDLNJDQLI-LBPRGKRZSA-N

物化性质

• 熔点：
  187-190 °C
• 沸点：
  450.9±38.0 °C(Predicted)
• 密度：
  1.171±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  16
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  66.4
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  N-Acetyl-α-methylphenylalanin 在 氢氧化钾 、 乙酸酐 作用下， 反应 6.0h， 生成 (-)-N-Acetyl-S-α-methyl-phenylalanin
  参考文献：
  名称：

  Terashima,S. et al., Chemical and pharmaceutical bulletin, 1966, vol. 14, p. 1138 - 1143

  摘要：

  DOI：

文献信息

• [EN] ENANTIOMERICALLY ENRICHED AMINODIPHOSPHINES AS LIGANDS FOR THE PREPARATION OF CATALYSTS FOR ASYMMETRIC SYNTHESIS<br/>[FR] AMINODIPHOSPHINES ÉNANTIOMÉRIQUEMENT ENRICHIES COMME LIGANDS POUR LA PRÉPARATION DE CATALYSEURS POUR UNE SYNTHÈSE ASYMÉTRIQUE
  申请人：ENANTIA S L

  公开号：WO2011098160A1

  公开（公告）日：2011-08-18

  The present invention relates to enantiomerically enriched aminodiphosphine ligands where the chirality is located in the phosphorus atom and their preparation process, to catalysts containing them and their preparation process, as well as their use in asymmetric synthesis.

  本发明涉及富含对映体的氨基二膦配体，其中手性位于磷原子上，以及它们的制备过程，包含它们的催化剂和其制备过程，以及它们在不对称合成中的应用。
• Enantiomerically Enriched Aminodiphosphines as Ligands for the Preparation of Catalysts for Asymmetric Synthesis
  申请人：Alonso Xalma Mónica

  公开号：US20120309997A1

  公开（公告）日：2012-12-06

  The present invention relates to enantiomerically enriched aminodiphosphine ligands where the chirality is located in the phosphorus atom and their preparation process, to catalysts containing them and their preparation process, as well as their use in asymmetric synthesis.

  本发明涉及手性富集的氨基二膦配体，其中手性位于磷原子上，以及它们的制备过程，包含它们的催化剂和其制备过程，以及它们在不对称合成中的应用。
• Enzymatic resolution of alpha-tertiary carboxylic acid esters
  申请人：GENZYME CORPORATION

  公开号：EP0512848A2

  公开（公告）日：1992-11-11

  A method for the resolution of α-tertiary carboxylic acid esters by partial hydrolysis is disclosed. The partial hydrolysis is carried out by contacting the esters with an aqueous solution in the presence of an enzyme, and the hydrolysis product is separated from unreacted starting material to obtain the hydrolysis product or the unreacted starting material in enantiomerically enriched form. A novel, purified enzyme which is useful in this method, and a nucleotide sequence encoding this enzyme, are also described.

  本发明公开了一种通过部分水解法解析α-叔羧酸酯的方法。部分水解是在酶存在的情况下将酯与水溶液接触，然后将水解产物与未反应的起始物质分离，得到对映体富集形式的水解产物或未反应的起始物质。此外，还介绍了一种可用于该方法的新型纯化酶和编码这种酶的核苷酸序列。
• Biocatalytic resolution of tertiary .alpha.-substituted carboxylic acid esters: efficient preparation of a quaternary asymmetric carbon center
  作者：Christopher Yee、Todd A. Blythe、Thomas J. McNabb、Alan E. Walts

  DOI：10.1021/jo00039a004

  日期：1992.6

  A method for resolving a variety of tertiary alpha-substituted carboxylic acid
• ENANTIOMERICALLY ENRICHED AMINODIPHOSPHINES AS LIGANDS FOR THE PREPARATION OF CATALYSTS FOR ASYMMETRIC SYNTHESIS
  申请人：Enantia, S.L.

  公开号：EP2534161A1

  公开（公告）日：2012-12-19