tert-butyl (4R)-4-(propylcarbamoyl)-1,3-thiazolidine-3-carboxylate

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: tert-butyl (4R)-4-(propylcarbamoyl)-1,3-thiazolidine-3-carboxylate
• 化学式: C₁₂H₂₂N₂O₃S
• 分子量: 274.384
• InChiKey: HOKSDFJRHDYHPA-VIFPVBQESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  18
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  83.9
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  tert-butyl (4R)-4-(propylcarbamoyl)-1,3-thiazolidine-3-carboxylate 在 盐酸 作用下， 以 1,4-二氧六环 为溶剂， 生成 (R)-Thiazolidine-4-carboxylic acid propylamide
  参考文献：
  名称：

  α-Substituted hydroxamic acids as novel bacterial deformylase inhibitor-based antibacterial agents

  摘要：

  We report the synthesis and biological activity of analogues of VRC3375 (N-hydroxy-3-R-butyl-3-[(2-S-(tert-butoxycarbonyl)-pyrrolidin-1-ylcarbonyl]propionamide), an orally active peptide deformylase inhibitor. This study explores the structureactivity relationship of various chelator groups, alpha substituents, P-2' and P-3' substituents in order to achieve optimal antibacterial activity with minimal toxicity liability. (C) 2003 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2003.07.020
• 作为产物：
  描述：

  二碳酸二叔丁酯 在 碳酸氢钠 、 二乙胺 、 N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate 作用下， 以 1,4-二氧六环 、 N,N-二甲基甲酰胺 为溶剂， 反应 32.0h， 生成 tert-butyl (4R)-4-(propylcarbamoyl)-1,3-thiazolidine-3-carboxylate
  参考文献：
  名称：

  α-Substituted hydroxamic acids as novel bacterial deformylase inhibitor-based antibacterial agents

  摘要：

  We report the synthesis and biological activity of analogues of VRC3375 (N-hydroxy-3-R-butyl-3-[(2-S-(tert-butoxycarbonyl)-pyrrolidin-1-ylcarbonyl]propionamide), an orally active peptide deformylase inhibitor. This study explores the structureactivity relationship of various chelator groups, alpha substituents, P-2' and P-3' substituents in order to achieve optimal antibacterial activity with minimal toxicity liability. (C) 2003 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2003.07.020

文献信息

• α-Substituted hydroxamic acids as novel bacterial deformylase inhibitor-based antibacterial agents
  作者：R. Jain、A. Sundram、S. Lopez、G. Neckermann、C. Wu、C. Hackbarth、D. Chen、W. Wang、N.S. Ryder、B. Weidmann、D. Patel、J. Trias、R. White、Z. Yuan

  DOI：10.1016/j.bmcl.2003.07.020

  日期：2003.12

  We report the synthesis and biological activity of analogues of VRC3375 (N-hydroxy-3-R-butyl-3-[(2-S-(tert-butoxycarbonyl)-pyrrolidin-1-ylcarbonyl]propionamide), an orally active peptide deformylase inhibitor. This study explores the structureactivity relationship of various chelator groups, alpha substituents, P-2' and P-3' substituents in order to achieve optimal antibacterial activity with minimal toxicity liability. (C) 2003 Elsevier Ltd. All rights reserved.