propan-2-yl (2S)-3-(1H-indol-3-yl)-2-[(4-methylphenyl)sulfanylamino]propanoate | 1421695-40-0

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: propan-2-yl (2S)-3-(1H-indol-3-yl)-2-[(4-methylphenyl)sulfanylamino]propanoate
• CAS: 1421695-40-0
• 化学式: C₂₁H₂₄N₂O₂S
• 分子量: 368.5
• InChiKey: GIZUNAVRISVFON-FQEVSTJZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5
• 重原子数：
  26
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  79.4
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  L-色氨酸 在 三乙胺 作用下， 以 乙醚 为溶剂， 反应 0.5h， 生成 propan-2-yl (2S)-3-(1H-indol-3-yl)-2-[(4-methylphenyl)sulfanylamino]propanoate
  参考文献：
  名称：

  Synthesis and evaluation of novel sulfenamides as novel anti Methicillin-resistant Staphylococcus aureus agents

  摘要：

  A total of 29 novel sulfenamide compounds were synthesized, spectroscopically characterized and evaluated in vitro for antimicrobial activity against various infectious pathogens. Compounds 1b and 2c exhibited potent inhibition against clinical Methicillin-resistant Staphylococcus aureus (MRSA) strains with minimum inhibitory concentration (MIC) values of 1.56 mu g/mL. (c) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2012.11.103

文献信息

• Synthesis and evaluation of novel sulfenamides as novel anti Methicillin-resistant Staphylococcus aureus agents
  作者：Jian-Li Shang、Hui Guo、Zai-Shun Li、Biao Ren、Zheng-Ming Li、Huan-qin Dai、Li-Xin Zhang、Jian-Guo Wang

  DOI：10.1016/j.bmcl.2012.11.103

  日期：2013.2

  A total of 29 novel sulfenamide compounds were synthesized, spectroscopically characterized and evaluated in vitro for antimicrobial activity against various infectious pathogens. Compounds 1b and 2c exhibited potent inhibition against clinical Methicillin-resistant Staphylococcus aureus (MRSA) strains with minimum inhibitory concentration (MIC) values of 1.56 mu g/mL. (c) 2012 Elsevier Ltd. All rights reserved.