1-oxo-pentane-1,2,5-tricarboxylic acid triethyl ester | 75632-04-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 1-oxo-pentane-1,2,5-tricarboxylic acid triethyl ester
• 英文别名: 1-Oxo-pentan-1,2,5-tricarbonsaeure-triaethylester；Triethyl 1-oxopentane-1,2,5-tricarboxylate；triethyl 1-oxopentane-1,2,5-tricarboxylate
• CAS: 75632-04-1
• 化学式: C₁₄H₂₂O₇
• 分子量: 302.324
• InChiKey: WKJAQCVPLTYNIY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  21
• 可旋转键数：
  13
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  96
• 氢给体数：
  0
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  1-oxo-pentane-1,2,5-tricarboxylic acid triethyl ester 在 sodium hydroxide 作用下， 生成 3-(3-carboxy-propyl)-4-hydroxy-quinoline-2-carboxylic acid
  参考文献：
  名称：

  Stefanovic; Celap, Recueil des Travaux Chimiques des Pays-Bas, 1953, vol. 72, p. 825,831

  摘要：

  DOI：
• 作为产物：
  描述：

  己二酸二乙酯 、 草酸二乙酯 生成 1-oxo-pentane-1,2,5-tricarboxylic acid triethyl ester
  参考文献：
  名称：

  The oxygen concentrator is a suitable alternative to oxygen cylinders in Nepal

  摘要：

  Purpose: To review the efficacy and reliability of oxygen concentrators used over the last six years in Nepal. The apparatus used was a DeVilbiss(R) oxygen concentrator that provided O-2 for anesthesia supplemented with compressed air to drive a Penlon Manley Multivent Ventilator(R). It remains difficult to supply oxygen in cylinders to peripheral hospitals in Nepal due to lack of proper roads.Methods: We conducted a retrospective analysis of a sample of 378 cases anesthetized at the Bir Hospital and at a private hospital in Kathmandu from April through October 1999. The Bain circuit or its modification was used in adults, and Bain or Ayre's T piece in children. High flows from the oxygen concentrator used with the Bain and Ayre's T circuits were reduced to 2 L(.)min(-1), delivered through the halothane vaporizer, supplemented by room air in the modified Bain circuit. Positive pressure ventilation was provided with an Ambubag, Oxford Inflating Bellows or Penlon Manley Multivent Ventilator. Blood pressure, electrocardiogram, FiO(2) and SpO(2) were monitored in all cases.Results: Surgery included urologic, general surgery, obstetrics and gynecological procedures, neurosurgery and closed mitral valvotomy. Age ranged from six months to 78 yr. The anesthetic time lasted from 45 min to 12 hr. The FiO(2) ranged from 0.5 to 0.6 in the Bain and Ayre's T circuits, and from 0.34 to 0.40 in the modified Bain circuit with a flow of oxygen of 2 L(.)min(-1) from the concentratorConclusion: With regular maintenance and servicing done locally, the oxygen concentrator can be used safely in adults and children. Use of the oxygen concentrator is a suitable alternative to oxygen cylinders in the developing world.

  DOI：

  10.1007/bf03020412

文献信息

• Management of Multiple Spontaneous Nasal Meningoencephaloceles
  作者：Rodney J. Schlosser、William E. Bolger

  DOI：10.1097/00005537-200206000-00008

  日期：2002.6

  AbstractObjectives/Hypothesis Multiple spontaneous nasal meningoencephaloceles in the same patient are rare lesions. Although many skull base defects occur after prior trauma or surgery, otolaryngologists must be aware of the potential for spontaneous encephaloceles. We present our experience with this unusual condition and discuss its pathophysiology and unique management issues.Study Design Retrospective.Methods Review of medical records, radiographic images, and cerebrospinal fluid pressures.Results We identified 5 patients with multiple, simultaneous, spontaneous encephaloceles: 4 patients with 2 encephaloceles and 1 patient with 3 encephaloceles (11 in all). Locations of the 11 encephaloceles were sphenoid lateral recess (6), frontal sinus with supraorbital ethmoid extension (2), ethmoid roof (1), frontal sinus (1), and central sphenoid (1). Three patients had bilateral sphenoid lateral recess encephaloceles, accounting for all six in that location. All four patients with available radiographic studies demonstrated empty sella turcica. Surgical approaches included endoscopic transpterygoid approach to the lateral sphenoid recess (3), endoscopic approach to ethmoid and central sphenoid (3), and osteoplastic flap with frontal sinus obliteration (2). We had 100% success at latest endoscopic follow‐up (mean period, 17 mo). Three patients had postoperative lumbar punctures with mean cerebrospinal fluid pressure of 28.3 cm water (range, 19–34 cm; normal range, 0–15 cm).Conclusions Multiple spontaneous encephaloceles can be managed safely and successfully using endoscopic and extracranial approaches. A high index of suspicion for this diagnosis must be maintained, especially in patients with radiographic evidence of laterally pneumatized sphenoid sinuses or empty sella. Spontaneous encephaloceles and cerebrospinal fluid leaks represent a form of intracranial hypertension.
• Wislicenus; Schwanhaeusser, Justus Liebigs Annalen der Chemie, 1897, vol. 297, p. 110
  作者：Wislicenus、Schwanhaeusser

  DOI：——

  日期：——
• Process for the production of indole acids
  申请人：MERCK & CO INC

  公开号：US02248155A1

  公开（公告）日：1941-07-08
• Bioconversion Process for Producing Nylon-7, Nylon-7, 7 and Polyesters
  申请人：Pearlman Paul S.

  公开号：US20140242655A1

  公开（公告）日：2014-08-28

  Embodiments of the present invention relate to methods for the biosynthesis of di- or trifunctional C7 alkanes in the presence of isolated enzymes or in the presence of a recombinant host cell expressing those enzymes. The di- or trifunctional C7 alkanes are useful as intermediates in the production of nylon-7, nylon-7,x, nylon-x,7, and polyesters.
• BIOCONVERSION PROCESS FOR PRODUCING NYLON-7, NYLON-7,7 AND POLYESTERS
  申请人：INVISTA North America S.A.R.L.

  公开号：US20170298396A1

  公开（公告）日：2017-10-19

  Embodiments of the present invention relate to methods for the biosynthesis of di- or trifunctional C7 alkanes in the presence of isolated enzymes or in the presence of a recombinant host cell expressing those enzymes. The di- or trifunctional C7 alkanes are useful as intermediates in the production of nylon-7, nylon-7,x, nylon-x,7, and polyesters.