4-[(1-pentyl-1H-indol-3-yl)carbonyl]naphthalene-1-carboxylic acid | 1541244-63-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 4-[(1-pentyl-1H-indol-3-yl)carbonyl]naphthalene-1-carboxylic acid
• 英文别名: 4-(1-pentyl-1H-indole-3-carbonyl)naphthalene-1-carboxylic acid；4-(1-Pentylindole-3-carbonyl)naphthalene-1-carboxylic acid；4-(1-pentylindole-3-carbonyl)naphthalene-1-carboxylic acid
• CAS: 1541244-63-6
• 化学式: C₂₅H₂₃NO₃
• 分子量: 385.463
• InChiKey: UCIYPTLBFXMREA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.8
• 重原子数：
  29
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  59.3
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  4-[(1-pentyl-1H-indol-3-yl)carbonyl]naphthalene-1-carboxylic acid 在 草酰氯 作用下， 以 四氢呋喃 、 水 为溶剂， 反应 0.33h， 生成 N-methyl-4-[(1-pentyl-1H-indol-3-yl)carbonyl]naphthalene-1-carboxamide
  参考文献：
  名称：

  Peripherally Selective Cannabinoid 1 Receptor (CB1R) Agonists for the Treatment of Neuropathic Pain

  摘要：

  Alleviation of neuropathic pain by cannabinoids is limited by their central nervous system (CNS) side effects. Indole and indene compounds were engineered for high hCB1R affinity, peripheral selectivity, metabolic stability, and in vivo efficacy. An epithelial cell line assay identified candidates with blood brain barrier penetration for testing in a rat neuropathy induced by unilateral sciatic nerve entrapment (SNE). The SNE-induced mechanical allodynia was reversibly suppressed, partially or completely, after intraperitoneal or oral administration of several indenes. At doses-that relieve neuropathy symptoms, the indenes completely lacked, while the brain-permeant CB1R agonist HU-210 (1) exhibited strong CNS side effects, in catalepsy, hypothermia, and motor incoordination assays. Pharmacokinetic findings of similar to 0.001 cerebrospinal fluid:plasma ratio further supported limited CNS penetration. Pretreatment with selective CB1R or CB2R blockers suggested mainly CB1R contribution to an indene's antiallodynic effects. Therefore, this class of CB1R agonists holds promise as a viable treatment for neuropathic pain.

  DOI：

  10.1021/acs.jmedchem.6b00516
• 作为产物：
  描述：

  ethyl 4-[(1-pentyl-1H-indol-3-yl)carbonyl]naphthalene-1-carboxylate 在 水 、 sodium hydroxide 作用下， 以 1,4-二氧六环 为溶剂， 反应 3.0h， 以73%的产率得到4-[(1-pentyl-1H-indol-3-yl)carbonyl]naphthalene-1-carboxylic acid
  参考文献：
  名称：

  Peripherally Selective Cannabinoid 1 Receptor (CB1R) Agonists for the Treatment of Neuropathic Pain

  摘要：

  Alleviation of neuropathic pain by cannabinoids is limited by their central nervous system (CNS) side effects. Indole and indene compounds were engineered for high hCB1R affinity, peripheral selectivity, metabolic stability, and in vivo efficacy. An epithelial cell line assay identified candidates with blood brain barrier penetration for testing in a rat neuropathy induced by unilateral sciatic nerve entrapment (SNE). The SNE-induced mechanical allodynia was reversibly suppressed, partially or completely, after intraperitoneal or oral administration of several indenes. At doses-that relieve neuropathy symptoms, the indenes completely lacked, while the brain-permeant CB1R agonist HU-210 (1) exhibited strong CNS side effects, in catalepsy, hypothermia, and motor incoordination assays. Pharmacokinetic findings of similar to 0.001 cerebrospinal fluid:plasma ratio further supported limited CNS penetration. Pretreatment with selective CB1R or CB2R blockers suggested mainly CB1R contribution to an indene's antiallodynic effects. Therefore, this class of CB1R agonists holds promise as a viable treatment for neuropathic pain.

  DOI：

  10.1021/acs.jmedchem.6b00516

文献信息

• PERIPHERALLY-ACTING CANNABINOID RECEPTOR AGONISTS FOR CHRONIC PAIN
  申请人：The Regents of the University of California

  公开号：US20150239859A1

  公开（公告）日：2015-08-27

  Peripherally acting cannabinoid agonist compounds, pharmaceutical compositions, and methods of using them are presented.

  本文介绍了外周作用的大麻素激动剂化合物、制药组合物以及使用它们的方法。
• US9656981B2
  申请人：——

  公开号：US9656981B2

  公开（公告）日：2017-05-23