1-甲氧基-3-[(3-甲氧基苯氧基)甲氧基]苯 | 56207-33-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 中文名称: 1-甲氧基-3-[(3-甲氧基苯氧基)甲氧基]苯
• 英文名称: formaldehyde-[bis-(3-methoxy-phenyl)-acetal]
• 英文别名: Formaldehyd-[bis-(3-methoxy-phenyl)-acetal]；Bis-(3-methoxy-phenoxy)-methan；Bis(3-methoxyphenoxy)methane；1-methoxy-3-[(3-methoxyphenoxy)methoxy]benzene
• CAS: 56207-33-1
• 化学式: C₁₅H₁₆O₄
• 分子量: 260.29
• InChiKey: UEVJKBFAIPMWAQ-UHFFFAOYSA-N

物化性质

• 沸点：
  408.7±30.0 °C(Predicted)
• 密度：
  1.132±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  19
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  36.9
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  1-甲氧基-3-[(3-甲氧基苯氧基)甲氧基]苯 在 正丁基锂 、 碘 作用下， 生成 2-Iodo-1-[(2-iodo-3-methoxyphenoxy)methoxy]-3-methoxybenzene
  参考文献：
  名称：

  Two new efficient preparations of enantiopure 2,2′-dihydroxy-6,6′-dimethoxy-1,1′-biphenyl

  摘要：

  Two new useful methods for the preparation of diol 1 starting from available compounds are described. Separation of the two enantiomers entails resolution of racemic diol 1 via the corresponding diastereomeric N-methylated phosphorothioamidates. Their separation by recrystallization followed by reduction afforded diol (aS)-1 and (aR)-1 in 100% and 72% ee, respectively. (C) 1997 Elsevier Science Ltd.

  DOI：

  10.1016/s0957-4166(97)00021-9
• 作为产物：
  描述：

  3-甲氧基苯酚 、 二氯甲烷 在 N-甲基吡咯烷酮 、 sodium hydride 作用下， 反应 4.0h， 以98%的产率得到1-甲氧基-3-[(3-甲氧基苯氧基)甲氧基]苯
  参考文献：
  名称：

  Practical Synthesis of Diaryloxymethanes

  摘要：

  Diaryloxymethanes were prepared by treating phenols with sodium hydride and dichloromethane in N-methyl-pyrrolidinone (NMP) at 40degreesC.

  DOI：

  10.1081/scc-120021995

文献信息

• Room‐Temperature Ionic Liquid–Promoted Williamson's Synthesis of Ethers: A Facile Synthesis of Diaryloxymethanes
  作者：S. V. More、S. S. Ardhapure、N. H. Naik、S. R. Bhusare、W. N. Jadhav、R. P. Pawar

  DOI：10.1080/00397910500281267

  日期：2005.12.1

  A simple and efficient method has been developed for the synthesis of phenolic ethers using room-temperature ionic liquid, not only as solvent but also as promoter. Ionic liquid was recycled and subsequently reused without any loss of the product.
• CCXL.—Cyclic esters of sulphuric acid. Part I. The reactions of methylene sulphate
  作者：Wilson Baker

  DOI：10.1039/jr9310001765

  日期：——
• Preparation and resolution of 2,2′-dimercapto-6,6′-dimethoxy-1,1′-biphenyl: a C2-symmetric sulfur building block
  作者：Giovanna Delogu、Davide Fabbri、Maria Antonietta Dettori

  DOI：10.1016/s0957-4166(98)00278-x

  日期：1998.8

  The preparation of the title dimercaptan 1 starting from 2,2'-dihydroxy-6,6'-dimethoxy-1,1'-biphenyl 2 is described, Resolution of dimercaptan 1 was performed using (-)-(1R,2S,5R)-menthyl chloroformate as a chiral resolving agent. The procedure affords dimercaptan (+)-1 and (-)-1 in 98% ee and 93% ee, respectively. A new and direct intermolecular Ullmann coupling resulting in an improved preparation of diol 2 is also reported. (C) 1998 Elsevier Science Ltd. All rights reserved.
• US4299636A
  申请人：——

  公开号：US4299636A

  公开（公告）日：1981-11-10
• Practical Synthesis of Diaryloxymethanes
  作者：Wenming Liu、Joanna Szewczyk、Liladhar Waykole、Oljan Repič、Thomas J. Blacklock

  DOI：10.1081/scc-120021995

  日期：2003.1.8

  Diaryloxymethanes were prepared by treating phenols with sodium hydride and dichloromethane in N-methyl-pyrrolidinone (NMP) at 40degreesC.