2-(2-methoxyphenyl)-4H-benzo[h]chromen-4-one | 14756-21-9

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 黄酮类化合物
• 英文名称: 2-(2-methoxyphenyl)-4H-benzo[h]chromen-4-one
• 英文别名: 2′-methoxy-alpha-naphthoflavone；2'-methoxy-α-naphthoflavone；2'-methoxy-α-naphtoflavone；2'-methoxy-7,8-benzoflavone；2-(2-methoxy-phenyl)-benzo[h]chromen-4-one；2-(2-Methoxy-phenyl)-benzo[h]chromen-4-on；2-(2-Methoxyphenyl)benzo[h]chromen-4-one
• CAS: 14756-21-9
• 化学式: C₂₀H₁₄O₃
• 分子量: 302.329
• InChiKey: ZPCVGYBSUXVZLD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  23
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  1-(1-hydroxy-[2]naphthyl)-3-(2-methoxy-phenyl)-propane-1,3-dione 在 乙醇 、 硫酸 作用下， 生成 2-(2-methoxyphenyl)-4H-benzo[h]chromen-4-one
  参考文献：
  名称：

  387.色酮类的合成实验。第十四部分。磺胺对1-酰氧基-2-乙酰萘的作用

  摘要：

  DOI：

  10.1039/jr9340001767

文献信息

• Synthesis of methoxybenzoflavones and assignments of their NMR data
  作者：Doseok Hwang、Geunhyeong Jo、Jiye Hyun、Sung Dae Lee、Dongsoo Koh、Yoongho Lim

  DOI：10.1002/mrc.3790

  日期：2012.1

  also is a potent phytotoxin. Six 7,8‐benzoflavones and eight 5,6‐benzoflavones were synthesized in this study. The NMR data for a few of these compounds have been previously reported; however, the NMR data for most of them have not been reported. For reference purposes, the complete NMR data for the 14 benzoflavones are described. Copyright © 2012 John Wiley & Sons, Ltd.

  来自 Acroptilon repens 的植物毒性根系分泌物被鉴定为 7,8-苯黄酮，一种细胞色素 P450 1A2 抑制剂和细胞色素 P450 3A4 激活剂。合成的 5,6-苯并黄酮也是一种有效的植物毒素。本研究合成了 6 种 7,8-苯并黄酮和 8 种 5,6-苯并黄酮。其中一些化合物的 NMR 数据以前已经报道过；然而，其中大部分的核磁共振数据尚未报道。出于参考目的，描述了 14 种苯黄酮的完整 NMR 数据。版权所有 © 2012 John Wiley & Sons, Ltd.
• Tire with rubber containing flavone
  申请人：THE GOODYEAR TIRE & RUBBER COMPANY

  公开号：EP1391327A1

  公开（公告）日：2004-02-25

  The invention relates to a rubber composition and a pneumatic tire having a component comprising a rubber containing the reaction product of a flavone and a methylene donor.

  本发明涉及一种橡胶组合物和充气轮胎，其成分包括含有黄酮和亚甲基供体反应产物的橡胶。
• Rubber composition and tire with rubber containing flavone
  申请人：The Goodyear Tire & Rubber Company

  公开号：EP2730431A1

  公开（公告）日：2014-05-14

  A rubber composition comprising a diene based elastomer and an adhesion promoter derived from a flavone, a methylene donor and a methylene acceptor is disclosed. The rubber composition is essentially free of cobalt. Also, a pneumatic tire comprising such a rubber composition is disclosed.

  本发明公开了一种橡胶组合物，该组合物包含一种二烯基弹性体和一种由黄酮、亚甲基供体和亚甲基受体衍生的附着力促进剂。该橡胶组合物基本上不含钴。此外，还公开了一种包含这种橡胶组合物的充气轮胎。
• Fungal metabolism of naphthoflavones
  作者：Jarosław Popłoński、Sandra Sordon、Tomasz Tronina、Agnieszka Bartmańska、Ewa Huszcza

  DOI：10.1016/j.molcatb.2015.04.007

  日期：2015.7

  Naphthoflavones (benzoflavones) are synthetic flavonoids commonly used in drug metabolism studies as selective activators or inhibitors of cytochrome P-450 enzymes. Nowadays they are also used as a component of food supplements for body builders. There is no data regarding naphthoflavone microbial metabolism. In the present studies sixty-three fungal strains have been screened for their ability to transform alpha-naphthoflavone (7,8-benzoflavone) or beta-naphthoflavone (5,6-benzoflavone). Five strains belonging to the genera Penicillium, Cladosporium, Aspergillus and Verticillium transformed alpha-naphthoflavone and beta-naphthoflavone to the corresponding 4'-hydroxy derivatives. These selected fungi have been used in a further study on biotransformation of naphthoflavones with a differently substituted B-ring. Only 4'-methoxy derivatives have been transformed to the related 4'-hydroxy products. Selected strains are good biocatalysts to obtain 4'-hydroxy naphthoflavones in the one step reaction. (C) 2015 Elsevier B.V. All rights reserved.
• USE OF FLAVONES, COUMARINS AND RELATED COMPOUNDS TO TREAT INFECTIONS
  申请人：Prendergast, Patrick Thomas

  公开号：EP1223928A2

  公开（公告）日：2002-07-24