symmetric anhydride of Boc-Pro-OH | 33294-56-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: symmetric anhydride of Boc-Pro-OH
• 英文别名: N-Boc-proline anhydride；1-O-tert-butyl 2-O-[(2S)-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidine-2-carbonyl] (2S)-pyrrolidine-1,2-dicarboxylate
• CAS: 33294-56-3
• 化学式: C₂₀H₃₂N₂O₇
• 分子量: 412.483
• InChiKey: JKAAHFHXTOGATB-KBPBESRZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  29
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  102
• 氢给体数：
  0
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  symmetric anhydride of Boc-Pro-OH 在 N-甲基吗啉 、 盐酸 作用下， 以 二氯甲烷 、 乙酸乙酯 为溶剂， 生成
  参考文献：
  名称：

  Hydrazino和N-Amino肽。化学和结构方面

  摘要：

  为了研究酰肼和N-氨基酰胺的拟肽基团，研究了肼基乙酸中氮的区域选择性酰化，还考虑了它们对β-turn结构的构象影响。

  DOI：

  10.1016/0040-4039(91)85080-o
• 作为产物：
  描述：

  BOC-L-脯氨酸 在 三乙胺 、 二苯基次膦酰氯 作用下， 以 二氯甲烷 为溶剂， 反应 2.0h， 生成 symmetric anhydride of Boc-Pro-OH
  参考文献：
  名称：

  Naphthylene derivatives as cytochrome P450 inhibitors

  摘要：

  该公式化合物及其药学上可接受的盐，其中n1、n2、n3、n4、G1、Q1、Z、R1、R2、R3、R4a、R4b、R5a和R5b在此处被定义，抑制细胞色素P450RAI酶，并可用于治疗和/或预防对维甲酸类药物和天然发生的维甲酸酸反应的各种疾病和症状。

  公开号：

  US20060009645A1

文献信息

• Naphthylene derivatives as cytochrome P450 inhibitors
  申请人：Smith Vanessa

  公开号：US20060009645A1

  公开（公告）日：2006-01-12

  Compounds of the formula and pharmaceutically acceptable salts thereof, wherein n 1 , n 2 , n 3 , n 4 , G 1 , Q 1 , Z, R 1 , R 2 , R 3 , R 4a , R 4b , R 5a , and R 5b are defined herein, inhibit the cytochrome P 450 RAI enzyme and are useful for the treatment and/or prevention of various diseases and conditions which respond to treatment by retinoids and by naturally occurring retinoic acid.

  该公式化合物及其药学上可接受的盐，其中n1、n2、n3、n4、G1、Q1、Z、R1、R2、R3、R4a、R4b、R5a和R5b在此处被定义，抑制细胞色素P450RAI酶，并可用于治疗和/或预防对维甲酸类药物和天然发生的维甲酸酸反应的各种疾病和症状。
• Polymer-supported synthesis of protected peptide segments on a photosensitive o-nitro(a-methyl)bromobenzyl resin
  作者：A. Ajayaghosh、V.N. Rajasekharan Pillai

  DOI：10.1016/s0040-4020(01)90104-8

  日期：1988.1

  The preparation of a new polystyrene support containing the photodetachable -nitro(α -methyl)benzyl anchoring group and its application in the solid phase synthesis of fully protected C-terminal peptides are described, The preparation of the photosensitive resin involves a 4-step polymer-analogous reaction starting from 1 %-divinyl benzene crosslinked polystyrene. Amino acid units were incorporated

  描述了一种新型的含有光可分离的-硝基（α-甲基）苄基锚定基团的聚苯乙烯载体的制备及其在完全保护的C-末端肽的固相合成中的应用。光敏树脂的制备涉及4步聚合物-类似反应从1％-二乙烯基苯交联的聚苯乙烯开始。按照标准固相肽合成方法，将氨基酸单元掺入该树脂中，并在中性条件下于350 nm通过光解从载体上裂解肽，总收率为40％至50％。肽通过就位的仲酯键连接至硝基是允许肽从支持物光解裂解的因素。
• Peptide, adsorbent, method for production thereof, and method for use thereof
  申请人：AGENCY OF INDUSTRIAL SCIENCE & TECHNOLOGY MINISTRY OF INTERNATIONAL TRADE & INDUSTRY

  公开号：EP0318240A2

  公开（公告）日：1989-05-31

  There is disclosed a peptide possessing an ability to bind to the human antibody to the nicotinic acetylcholine receptor and represented by the formula: wherein A stands for a peptide residue, one of X and Y stands for a single bond, an amino acid residue selected from the class consisting of Asp, Glu, Lys and a divalent group represented by the formula, (wherein n stands for an integer in the range of 1 to 17), or a peptide residue formed by peptide linkage of two to ten amino acid residues of at least one species selected from the class mentioned above and the other of X and Y stands for an amino acid residue selected from the class consisting of Asp, Glu, Lys and a divalent group represented by the formula, (wherein n stands for an integer in the range of 1 to 17), or a peptide residue formed by peptide linkage of two to ten amino acid residues of at least one species selected from the class mentioned above, and Z stands for a hydroxyl group or an amino group and an adsorbent having immobilized on a carrier the peptide mentioned above. A method for the production of the adsorbent and a method for the use of the adsorbent are also disclosed.

  本发明公开了一种肽，该肽具有与人类烟碱乙酰胆碱受体抗体结合的能力，并由式表示： 其中 A 代表肽残基，X 和 Y 中的一个代表单键，一个氨基酸残基选自由 Asp、Glu、Lys 和二价基团组成的类别，二价基团由式表示、 (其中 n 代表 1 至 17 范围内的整数），或由选自上述类别的至少一种的 2 至 10 个氨基酸残基肽键连接形成的肽残基，且 X 和 Y 中的另一个代表选自 Asp、Glu、Lys 和二价基团组成的类别的氨基酸残基，二价基团由式......表示、 (其中 n 代表 1 至 17 范围内的整数），或由至少一种选自上述类别的氨基酸残基的 2 至 10 个肽连接形成的肽残基，Z 代表羟基或氨基，以及将上述肽固定在载体上的吸附剂。此外，还公开了一种生产该吸附剂的方法和一种使用该吸附剂的方法。
• PEPTIDE AND ADSORBENT COMPRISING SAME IMMOBILIZED ON CARRIER
  申请人：KURARAY Co. LTD.

  公开号：EP0426857A1

  公开（公告）日：1991-05-15

  This invention relates to a peptide capable of combining with interleukin 6 and an adsorbent for interleukin 6 comprising said peptide immobilized on a carrier.

  本发明涉及一种能够与白细胞介素 6 结合的多肽，以及一种白细胞介素 6 吸附剂，该吸附剂包括固定在载体上的上述多肽。
• Synthesis of 1,2,4-Oxadiazole-, 1,3,4-Oxadiazole-, and 1,2,4-Triazole-Derived Dipeptidomimetics
  作者：Susanna Borg、Genevieve Estenne-Bouhtou、Kristina Luthman、Ingeborg Csoeregh、Willy Hesselink、Uli Hacksell

  DOI：10.1021/jo00115a029

  日期：1995.5

  Three series of heterocyclic dipeptidomimetics have been synthesized. The compounds were designed as amino acid-glycine mimetics containing 1,2,4-oxadiazole, 1,3,4-oxadiazole, and 1,2,4-triazole ring systems, useful as building blocks in the synthesis of modified peptides. The heterocyclic moieties were chosen according to their geometrical, electrostatical, and hydrogen bonding properties together with the synthetic accessibility. The syntheses started with Boc-protected L-amino acids (Ala, Gly, Asp, Phe, Ser, Arg, Cys, and Pro), and the reaction conditions were chosen to allow for the formation of products with high enantiopurity. The enantiomeric excess was determined by HPLC using chiral stationary phases.