N,N'-bis<2-(dimethylamino)ethyl>oxamide | 25148-93-0

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N,N'-bis<2-(dimethylamino)ethyl>oxamide
• 英文别名: N1,N2-bis(2-(dimethylamino)ethyl)oxalamide；N,N'-bis[2-(dimethylamino)ethyl]oxalamide；N,N'-bis[2-(dimethylamino)ethyl]oxamide；N,N'-bis[2-(dimethylamino)ethyl]oxamido；N,N'-bis(2-dimethylaminoethyl) oxamide；N,N'-bis-(2-dimethylamino-ethyl)-oxalamide；Ethanediamide, N,N'-bis[2-(dimethylamino)ethyl]-
• CAS: 25148-93-0
• 化学式: C₁₀H₂₂N₄O₂
• 分子量: 230.31
• InChiKey: IYUARWKVAFHXJL-UHFFFAOYSA-N

物化性质

• 熔点：
  123-124 °C
• 密度：
  1.046±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.7
• 重原子数：
  16
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  64.7
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  N,N'-bis<2-(dimethylamino)ethyl>oxamide 在 lithium aluminium tetrahydride 作用下， 以 四氢呋喃 为溶剂， 反应 72.0h， 以56%的产率得到N,N,N"',N"'-tetramethyltriethylenetetramine
  参考文献：
  名称：

  双（双，N，N'，N'-取代的1,2-乙二胺）配位体：合成与配位化学

  摘要：

  报道了通过仲胺（1型）或叔胺（2型）桥联的两种不同类型的双（N，N '，N'-取代的1,2-乙二胺）的合成。使用铝，镁，锡和锌源，已选择的蛋白质配体已用于后续的金属化反应中，从而可以分离出五个单核和八个双核配合物。所有配合物均已得到充分表征，并已通过单晶X射线衍射分析研究了其固态结构。13种络合物中的9种带有反应性烷基，酰胺或氢化物基团，这表明它们作为（过渡）金属的催化剂或载体的潜力。

  DOI：

  10.1039/d0dt03124k
• 作为产物：
  描述：

  草酸二甲酯 、 N,N-二甲基乙二胺 生成 N,N'-bis<2-(dimethylamino)ethyl>oxamide
  参考文献：
  名称：

  Dicarboxylic Acid Bis-β-tertiaryaminoalkyl Amides and their Quaternary Ammonium Salts as Curare Substitutes. II¹

  摘要：

  DOI：

  10.1021/ja01156a106

文献信息

• Oxamidato complexes. Part 6. Complex formation between copper(<scp>II</scp>) and N,N′-bis[2-(dimethylamino)ethyl]oxamide (H₂dmaeoxd). Preparation, crystal structure, and magnetic properties of [Cu₂(dmaeoxd)(NCO)₂(H₂O)₂]
  作者：José Antonio Real、Miquel Mollar、Rafael Ruiz、Juan Faus、Francesc Lloret、Miguel Julve、Michèle Philoche-Levisalles

  DOI：10.1039/dt9930001483

  日期：——

  pCu2++qL2–+rH+⇌[CupLqHr][2(p–q)+r]+ were log β212= 34.11(8), log β211= 29.52(8), log β210= 24.74(2), log β320= 44.87(5), log β430= 64.09(7) and log β110= 16.92(2). The compound of formula [Cu2(dmaeoxd)(NCO)2(H2O)2] has been synthesised and its crystal structure determined by single-crystal X-ray diffraction methods at room temperature. It crystallizes in the monoclinic system, space group P21/a and Z= 2, with

  的质子化和去质子化Ñ，Ñ ' -双[2-（二甲基氨基）乙基]草酰胺（H 2 dmaeoxd，H 2 L）和其复合体形成与铜II已经通过在水溶液中电位在25调查℃，0.1 mol dm –3 NaNO 3。质子结合常数β Ĵ对应于平衡大号2- + Ĵ ħ + ⇌ħ Ĵ大号（Ĵ -2）+被认为是日志β 2 = 24.0（2），对数β 3 = 32.63（1）和日志β 4= 40.46（1）。稳定常数β的值PQR关于平衡p的Cu 2+ + q大号2+ - [R ħ + ⇌[铜p大号q ħ - [R ] [2（p - q）+ [R ] +是日志β 212 = 34.11 （8），对数β 211 = 29.52（8），日志β 210 = 24.74（2），对数β 320 = 44.87（5），对数β 430 = 64.09（7）和logβ 110 = 16.92（2）。式[Cu 2（dmaeoxd）（NCO）2的化合物（H
• 具有抗癌作用的有机金属铂类化合物及其合成 方法
  申请人：德州学院

  公开号：CN103435657B

  公开（公告）日：2016-07-13

  本发明公开了一种具有抗癌作用的有机金属铂类化合物，其通过以下步骤合成，按现有方法合成具有N、O杂原子的有机配体N,N’?二(2?二甲基氨基?乙基)草酰胺L，然后该有机配体L与K2PtCl6在30摄氏度下反应6小时，静置到室温，过滤，在室温下自然挥发得到相应的晶体[Pt(II)Cl6]2?·L2+。其具有显著的抑制癌细胞增值的作用，可作为一种新型的铂类抗癌药进行使用；其制备方法易操作，容易进行工业推广及应用，也是本技术所具备的优越之处。
• μ-{<i>N</i>,<i>N</i>′-Bis[2-(dimethylamino)ethyl]oxamidato(2–)}-1κ²<i>O</i>,<i>O</i>′:2κ⁴<i>N</i>,<i>N</i>′,<i>N</i>′′,<i>N</i>′′′-bis(4,4′-dimethyl-2,2′-bipyridine-1κ²<i>N</i>,<i>N</i>′)dinickel(II) bis(perchlorate)
  作者：Wei Sun、Yan-Tuan Li、Zhi-Yong Wu、Ning-Yu Xiao

  DOI：10.1107/s010827010700282x

  日期：2007.3.15

  In the crystal structure of the title complex, [Ni-2(C10H20-N4O2)( C12H12N2)(2)](ClO4)(2) or [Ni(dmaeoxd)Ni(dmbp)(2)](ClO4)(2) H(2)dmaeoxd is N,N'-bis[2-(dimethylamino)ethyl]-oxamide and dmbp is 4,4'-dimethyl-2,2'-bipyridine}, the deprotonated dmaeoxd(2-) ligand is in a cis conformation and bridges two Ni-II atoms, one of which is located in a slightly distorted square-planar environment, while the other is in an irregular octahedral environment. The cation is located on a twofold symmetry axis running through both Ni atoms. The dmaeoxd(2-) ligands interact with each other via C-(HO)-O-... hydrogen bonds and pi-pi interactions, which results in an extended chain along the c axis.
• Synthesis and Magnetic Studies of μ‐Oxamido‐bridged Copper(II)–Manganese(II) Heterobinuclear Complexes
  作者：Yan‐Tuan Li、Cui‐Wei Yan、Chun‐Yuan Zhu、Hua‐Shi Guan

  DOI：10.1081/sim-120039264

  日期：2004.8.1

  Three new copper(II)-manganese(II) heterobinuclear complexes bridged by N,N'-bis[2-(dimethylamino)ethyl]oxamido dianion (dmoxae) and end-capped with 5-nitro-1,10-phenanthroline (NO(2)phen), 2,9-dimethyl-1,10-phenanthroline (Me(2)phen) or 5-phenyl-1,10-phenanthroline (Php-hen), respectively; namely, [Cu(dmoxae)Mn(NO(2)phen)(2)](ClO4)(2) (1), [Cu(dmoxae)Mn(Me(2)phen)(2)](ClO4)(2) (2), and [Cu(dmoxae)Mn(Php-hen)(2)](ClO4)(2) (3); have been synthesized and characterized by elemental analyses, IR and electronic spectral studies and molar conductivity measurements. It is proposed that these complexes have oxamido-bridged structures consisting of planar copper(II) and octahedral manganese(II) ions. The electronic reflectance spectra indicate the presence of exchange-coupling interaction between bridging copper(II) and manganese(II) ions. The cryomagnetic measurements (4.2-300 K) of the three complexes demonstrated the operation of antiferromagnetic interaction between the adjacent manganese(II) and copper(II) ions through the oxamido-bridge within these copper(II)-manganese(II) heterobinuclear complexes. On the basis of the spin Hamiltonian, (H) over cap = -2 (S) over cap (1).(S) over cap (2), a magnetic analysis was carried out for the three complexes and the spin-coupling constant (J) was evaluated as - 39.7 cm(-1) for (1), -38.5 cm(-1) for (2), and -37.8 cm(-1) for (3). The influence of methyl substituents in amine groups of the bridging ligand on magnetic interactions between the metal ions of this kind of complexes is also discussed.
• Aqua-2κ<i>O</i>-μ-{<i>N</i>,<i>N</i>′-bis[2-(dimethylamino)ethyl]oxamidato(2–)}-1κ²<i>O</i>,<i>O</i>′:2κ⁴<i>N</i>,<i>N</i>′,<i>N</i>′′,<i>N</i>′′′-bis(4,4′-dimethyl-2,2′-bipyridine-1κ²<i>N</i>,<i>N</i>′)copper(II)nickel(II) bis(perchlorate) methanol hemisolvate
  作者：Wei Sun、Yan-Tuan Li、Zhi-Yong Wu、Jin-Liang Liu

  DOI：10.1107/s0108270107042643

  日期：2007.10.15

  In the crystal structure of the title complex, [ CuNi( C10H20N4O2)( C12H8N2)(2)( H2O)]( ClO4) 2 center dot 0.5CH(4)O or [ CuNi( dmaeoxd)( phen)(2)( H2O)]( ClO4)(2) center dot 0.5CH(3)OH H(2)dmaeoxd is N, N'bis[ 2-( dimethylamino) ethyl] oxamide and phen is 1,10- phenanthroline}, the deprotonated dmaeoxd(2-). ligand is in a cis conformation and bridges the Cu-II and Ni-II atoms. The Cu-II atom is located in a slightly distorted square- based pyramidal environment, while the Ni-II atom is in an irregular octahedral environment. The binuclear Cu - Ni units interact with each other via pi-pi interactions, which results in an extended chain along the b axis.