Tert-butyl 3-(4-formylphenyl)-4,5-dihydro-1,2-oxazole-5-carboxylate | 274904-14-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Tert-butyl 3-(4-formylphenyl)-4,5-dihydro-1,2-oxazole-5-carboxylate
• CAS: 274904-14-2
• 化学式: C₁₅H₁₇NO₄
• 分子量: 275.304
• InChiKey: HSBFLFRDWGPJDO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  20
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  65
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  Tert-butyl 3-(4-formylphenyl)-4,5-dihydro-1,2-oxazole-5-carboxylate 、 (E)-3-(4-{2-[4-((E)-2-Hexadecylcarbamoyl-vinyl)-phenyl]-2-oxo-acetyl}-phenyl)-acrylic acid tert-butyl ester 在 ammonium acetate 、 溶剂黄146 作用下， 反应 2.0h， 以72%的产率得到3-(4-{4-[4-((E)-2-tert-butoxycarbonyl-vinyl)phenyl]-5-[4-(2-hexadecylcarbamoyl-vinyl)phenyl]-1H-imidazol-2-yl}phenyl)-4,5-dihydroisoxazole-5-carboxylic acid tert-butyl ester
  参考文献：
  名称：

  Development of Potent Non-Carbohydrate Imidazole-Based Small Molecule Selectin Inhibitors with Antiinflammatory Activity

  摘要：

  A novel series of non-carbohydrate imidazole-based selectin inhibitors has been discovered via high-throughput screening using a P-selectin ELISA-based assay system. The initial lead 1 had an IC(50) of 17 muM in the P-selectin ELISA; this potency was significantly improved via an extensive SAR exploration. One of the current lead compounds (29) has an IC(50) of 300 nM in a P-selectin ELISA; it also has good activity in P- and E-selectin cell adhesion assays and shows efficacy in vivo. These compounds represent a novel series of sLe(X) mimetics with antiinflammatory activity. Their unique profile supports our interest in their further evaluation as drug candidates for the treatment of inflammation. Herein we describe the syntheses, optimization, and SAR of this series of novel potent selectin antagonists.

  DOI：

  10.1021/jm000508c
• 作为产物：
  描述：

  丙烯酸叔丁酯 在 sodium hypochlorite 、 Amberlite IR-120 作用下， 以 四氢呋喃 、 水 为溶剂， 反应 23.0h， 生成 Tert-butyl 3-(4-formylphenyl)-4,5-dihydro-1,2-oxazole-5-carboxylate
  参考文献：
  名称：

  Development of Potent Non-Carbohydrate Imidazole-Based Small Molecule Selectin Inhibitors with Antiinflammatory Activity

  摘要：

  A novel series of non-carbohydrate imidazole-based selectin inhibitors has been discovered via high-throughput screening using a P-selectin ELISA-based assay system. The initial lead 1 had an IC(50) of 17 muM in the P-selectin ELISA; this potency was significantly improved via an extensive SAR exploration. One of the current lead compounds (29) has an IC(50) of 300 nM in a P-selectin ELISA; it also has good activity in P- and E-selectin cell adhesion assays and shows efficacy in vivo. These compounds represent a novel series of sLe(X) mimetics with antiinflammatory activity. Their unique profile supports our interest in their further evaluation as drug candidates for the treatment of inflammation. Herein we describe the syntheses, optimization, and SAR of this series of novel potent selectin antagonists.

  DOI：

  10.1021/jm000508c

文献信息

• [EN] 5-MEMBERED HETEROCYCLES FOR THE TREATMENT OF HUMAN DISEASES INVOLVING MODULATORS OF SELECTINS<br/>[FR] HETEROCYCLES A 5 CHAINONS POUR LE TRAITEMENT DE MALADIES HUMAINES DANS LESQUELLES INTERVIENNENT DES MODULATEURS DE SELECTINES
  申请人：ONTOGEN CORP

  公开号：WO2000033836A1

  公开（公告）日：2000-06-15

  Compounds of formulas (1), (2) and (3) are disclosed, where at least one and no more than two of R?1, R2, R3, R4 or R5¿ are as defined in Group 1. In said formulas R1 is typically a moiety containing a terminal carboxylic acid group such as phenoxy acetic acid, R2 is typically a hydrophobic moiety such as functionalized alkyl chain or a functionalized aryl group, and R3 is typically a functionalized aryl group, and they are within the scope of this invention. These compounds exhibit inhibitory activity against the Selectins and are indicated in the treatment of human diseases involving Selectins.