N-[(2R)-2-(cyclopentylmethyl)-3-oxo-3-[2-(pyridine-3-carbonyl)diazinan-1-yl]propyl]-N-hydroxyformamide | 1316663-10-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-[(2R)-2-(cyclopentylmethyl)-3-oxo-3-[2-(pyridine-3-carbonyl)diazinan-1-yl]propyl]-N-hydroxyformamide
• CAS: 1316663-10-1
• 化学式: C₂₀H₂₈N₄O₄
• 分子量: 388.467
• InChiKey: MFRJIKYAGLIWAE-GOSISDBHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  28
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  94
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  (R)-3-(N-(benzyloxy)formamido)-2-(cyclopentylmethyl)propanoic acid 在 palladium 10% on activated carbon 、 氢气 、 N,N-二异丙基乙胺 、 Methanaminium,N-[(dimethylamino)(3H-1,2,3-triazolo[4,5-b]pyridin-3-yloxy)methylene]-N-methyl-, hexafluorophosphate(1-) 作用下， 以 甲醇 、 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 生成 N-[(2R)-2-(cyclopentylmethyl)-3-oxo-3-[2-(pyridine-3-carbonyl)diazinan-1-yl]propyl]-N-hydroxyformamide
  参考文献：
  名称：

  Peptidomimetic inhibitors of bacterial peptide deformylase

  摘要：

  A series of N-formyl hydroxylamine peptide deformylase inhibitors containing a cyclic azaamino acid moiety between the P1' and P3' substituents are presented. Selected compounds display antibacterial activity against pathogens associated with respiratory tract infections with representative compounds showing excellent MICs against Haemophilus influenzae. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2011.04.132

文献信息

• Peptidomimetic inhibitors of bacterial peptide deformylase
  作者：Stephen P. East、Andrew Ayscough、Ian Toogood-Johnson、Steven Taylor、Wayne Thomas

  DOI：10.1016/j.bmcl.2011.04.132

  日期：2011.7

  A series of N-formyl hydroxylamine peptide deformylase inhibitors containing a cyclic azaamino acid moiety between the P1' and P3' substituents are presented. Selected compounds display antibacterial activity against pathogens associated with respiratory tract infections with representative compounds showing excellent MICs against Haemophilus influenzae. (C) 2011 Elsevier Ltd. All rights reserved.