| 903903-39-9

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• CAS: 903903-39-9
• 化学式: C₃₂H₅₂O₅Si
• 分子量: 544.847
• InChiKey: QYYBIZNZEOPZKR-YYKHYQNXSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.63
• 重原子数：
  38.0
• 可旋转键数：
  12.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.69
• 拓扑面积：
  72.83
• 氢给体数：
  1.0
• 氢受体数：
  5.0

反应信息

• 作为反应物：
  描述：

  在 吡啶 、 戴斯-马丁氧化剂 作用下， 以 二氯甲烷 为溶剂， 反应 1.58h， 以85%的产率得到
  参考文献：
  名称：

  A synthetic approach to enfumafungin

  摘要：

  The stereospecific synthesis of the dienophile subunits 5 was achieved from the butenolide 6. Ester 19 was obtained in 67% overall yield (2 steps), with no intermediate purification, by a sodium chlorite oxidation of the corresponding aldehyde in buffered conditions, followed immediately after extraction, by a Mitsunobu reaction of the relatively labile acid 3 with alcohol 13. The synthesis of the alpha,beta-unsaturated aldehydes 22 and 23 is also reported. Tentative IMDA reactions of 22 and 23 were examined in thermal conditions, or with a Lewis acid catalysis, and results are reported herein. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2006.04.113
• 作为产物：
  描述：

  4-(tert-Butyldimethylsilyloxy)-5-methyl-1-hexene 在 palladium diacetate 、 potassium phosphate 、 lithium aluminium tetrahydride 、 正丁基锂 、 氟化氢吡啶 、 三苯基膦 、 偶氮二甲酸二乙酯 作用下， 以 四氢呋喃 、 1,4-二氧六环 、 吡啶 、 正己烷 、 甲苯 为溶剂， 反应 13.25h， 生成
  参考文献：
  名称：

  A synthetic approach to enfumafungin

  摘要：

  The stereospecific synthesis of the dienophile subunits 5 was achieved from the butenolide 6. Ester 19 was obtained in 67% overall yield (2 steps), with no intermediate purification, by a sodium chlorite oxidation of the corresponding aldehyde in buffered conditions, followed immediately after extraction, by a Mitsunobu reaction of the relatively labile acid 3 with alcohol 13. The synthesis of the alpha,beta-unsaturated aldehydes 22 and 23 is also reported. Tentative IMDA reactions of 22 and 23 were examined in thermal conditions, or with a Lewis acid catalysis, and results are reported herein. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2006.04.113