2,5-di(3-bromophenyl)pyrrole | 362047-05-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯
• 英文名称: 2,5-di(3-bromophenyl)pyrrole
• 英文别名: 2,5-bis(3-bromophenyl)-1H-pyrrole
• CAS: 362047-05-0
• 化学式: C₁₆H₁₁Br₂N
• 分子量: 377.078
• InChiKey: QQKUEWSRIHXWAC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.87
• 重原子数：
  19.0
• 可旋转键数：
  2.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  15.79
• 氢给体数：
  1.0
• 氢受体数：
  0.0

反应信息

• 作为反应物：
  描述：

  2,5-di(3-bromophenyl)pyrrole 在 N-甲基吡咯烷酮 、 盐酸 作用下， 以 乙醇 为溶剂， 反应 144.0h， 生成 2,5-bis[3-([3-N,N-dimethylaminopropyl]amidino)phenyl]pyrrole
  参考文献：
  名称：

  Inhibition of the HIV-1 rev–RRE complex formation by unfused aromatic cations

  摘要：

  RNA viruses cause a wide range of human diseases. Development of new agents to target such viruses is an active area of research. Towards this goal, a series of diphenylfuran cations as potential inhibitors of the Rev-RRE complex have been designed and synthesized. Analysis of the interaction of the diphenylfurans with RRE and TAR RNA model systems by gel shift assays indicates that they exhibit both sequence and structure-dependent binding modes. Our results show a strong interaction between the diphenylfuran ring system and RRE bases, while the TAR interactions are much weaker with the compounds that are the best inhibitors of Rev-RRE. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0968-0896(00)00344-8
• 作为产物：
  描述：

  间溴苯甲醛 在 乙酸铵 、 3-benzyl-5-(2-hydroxyethyl)thiazolium chloride 、 sodium acetate 、 溶剂黄146 作用下， 以 乙醇 为溶剂， 反应 21.0h， 生成 2,5-di(3-bromophenyl)pyrrole
  参考文献：
  名称：

  Inhibition of the HIV-1 rev–RRE complex formation by unfused aromatic cations

  摘要：

  RNA viruses cause a wide range of human diseases. Development of new agents to target such viruses is an active area of research. Towards this goal, a series of diphenylfuran cations as potential inhibitors of the Rev-RRE complex have been designed and synthesized. Analysis of the interaction of the diphenylfurans with RRE and TAR RNA model systems by gel shift assays indicates that they exhibit both sequence and structure-dependent binding modes. Our results show a strong interaction between the diphenylfuran ring system and RRE bases, while the TAR interactions are much weaker with the compounds that are the best inhibitors of Rev-RRE. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0968-0896(00)00344-8

文献信息

• Synthesis, Structure, and Optical Properties of Di-<i>m</i>-benzihexaphyrins (1.1.0.0.0.0) and Di-<i>m</i>-benziheptaphyrins (1.0.1.0.0.0.0): Blackening of <i>m</i>-Phenylene-Linked Dicarbaporphyrinoids by Simple π-Expansion
  作者：Thondikkal Sulfikarali、Jayaprakash Ajay、Cherumuttathu H. Suresh、Padinjare V. Bijina、Sabapathi Gokulnath

  DOI：10.1021/acs.joc.0c00754

  日期：2020.6.19

  Acid-catalyzed condensation of a newly prepared di-m-benzipentapyrrane with appropriate mono- and diheterocyclic dialcohols selectively produced stable di-m-benzihexaphyrins and di-m-benziheptaphyrins with only two meso-carbon bridges. Single-crystal X-ray diffraction analyses reveal planar conformation with slight distortion of bridged phenylene rings. Despite the presence of m-phenylene units interrupting the global delocalization, the presence of bithiophene units in di-m-benziheptaphyrins 3a-b exhibits altered optical features covering the entire visible region (ca. 250-720 nm), exhibiting a black dye property as a "metal-free" porphyrinoid.