(17,17-dimethyl-16,17-dihydro-15H-cyclopenta[a]phenanthren-3-yl)-methyl ether | 61237-31-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 菲及其衍生物
• 英文名称: (17,17-dimethyl-16,17-dihydro-15H-cyclopenta[a]phenanthren-3-yl)-methyl ether
• 英文别名: 3-Methoxy-17.17-dimethyl-16.17-dihydro-15H-cyclopenta[a]phenanthren；(17,17-Dimethyl-16,17-dihydro-15H-cyclopenta[a]phenanthren-3-yl)-methyl-aether；3-Methoxy-17,17-dimethylgona-1(10),2,4,6,8,11,13-heptaene；3-methoxy-17,17-dimethyl-15,16-dihydrocyclopenta[a]phenanthrene
• CAS: 61237-31-8
• 化学式: C₂₀H₂₀O
• 分子量: 276.378
• InChiKey: DQIXLESWGCILGQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.1
• 重原子数：
  21
• 可旋转键数：
  1
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  3-甲氧基-17alpha-甲基雌甾-1,3,5(10)三烯-17beta-醇 生成 (17,17-dimethyl-16,17-dihydro-15H-cyclopenta[a]phenanthren-3-yl)-methyl ether
  参考文献：
  名称：

  Steroids. LIV.¹ Synthesis of 19-Nov-17α-ethynyltestosterone and 19-Nor-17α-methyltestosterone²

  摘要：

  DOI：

  10.1021/ja01645a010

文献信息

• 97. The synthesis of compounds related to the sterols, bile acids, and oestrus-producing hormones. Part VI. Experimental evidence of the complete structure of oestrin, equilin, and equilenin
  作者：A. Cohen、J. W. Cook、C. L. Hewett

  DOI：10.1039/jr9350000445

  日期：——
• Steroids. LIV.¹ Synthesis of 19-Nov-17α-ethynyltestosterone and 19-Nor-17α-methyltestosterone²
  作者：Carl Djerassi、L. Miramontes、G. Rosenkranz、Franz Sondheimer

  DOI：10.1021/ja01645a010

  日期：1954.8
• Beschichtung von Sitzsystemen auf Vordermann gebracht
  作者：Matthias Horber

  DOI：10.1007/bf03251062

  日期：2002.12
• The Total Synthesis of the Sex Hormone Equilenin and Its Stereoisomers
  作者：W. E. Bachmann、Wayne Cole、A. L. Wilds

  DOI：10.1021/ja01861a036

  日期：1940.4
• Potential hypolipidemic agents derived from 3-hydroxy-17,17-dimethylgona-1,3,5(10),8,11,13-hexaene
  作者：Leland J. Chinn、Karlene W. Salamon

  DOI：10.1021/jm00212a008

  日期：1977.2

  Numerous aryloxy derivatives containing a lipophilic group have been found to possess hypolipidemic activity. This has prompted the preparation of various derivatives of 3-hydroxy-17,17-dimethylgona-1,3,5(10),8,11,13-hexaene (6a). In 6a the lipophilic biphenyl group is incorporated into the steroid nucleus. A three-step synthesis of 6a from 17beta-methylestradiol methyl ether was developed. The derivatives prepared were tested in rats made hypercholesterolemic with propylthiouracil. Several were found active in this test.