(4R,5S)-2-(4-Methoxy-phenyl)-4,5-dimethyl-4-(4-methyl-pent-3-enyl)-[1,3]dioxane | 224580-02-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: (4R,5S)-2-(4-Methoxy-phenyl)-4,5-dimethyl-4-(4-methyl-pent-3-enyl)-[1,3]dioxane
• CAS: 224580-02-3
• 化学式: C₁₉H₂₈O₃
• 分子量: 304.43
• InChiKey: ZNAHBKKANKMJOH-JMRRQPBMSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.88
• 重原子数：
  22.0
• 可旋转键数：
  5.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.58
• 拓扑面积：
  27.69
• 氢给体数：
  0.0
• 氢受体数：
  3.0

反应信息

• 作为反应物：
  描述：

  (4R,5S)-2-(4-Methoxy-phenyl)-4,5-dimethyl-4-(4-methyl-pent-3-enyl)-[1,3]dioxane 在 N-甲基吲哚酮 、 四丙基高钌酸铵 、 叔丁基锂 、 二异丁基氢化铝 作用下， 以 二氯甲烷 为溶剂， 生成 (6R,7S)-6-(4-Methoxy-benzyloxy)-2,6,7-trimethyl-9-methylene-pentadec-2-en-8-ol
  参考文献：
  名称：

  2. Synthesis of the C.14–C.26 hydrophilic domain of amphidinolide B1 and formation of the (E)-1,1′,3-trisubstituted diene sector

  摘要：

  In the preceding letter, we described a synthesis of the conserved C.1-C.13 hydrophobic domain common to the potent B-type amphidinolides. In this letter, we present syntheses of the C.14-C.26 hydrophilic domain specific to amphidinolide B1 and a model for uniting the hydrophobic and hydrophilic domains to form the (E)-1,1',3-trisubstituted diene. (C) 1999 Published by Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(99)00207-5
• 作为产物：
  描述：

  (2R,3R)-3-methyl-3-(4-methyl-3-pentenyl)oxiranemethanol 在 camphor-10-sulfonic acid 作用下， 以 乙醚 、 二氯甲烷 为溶剂， 生成 (4R,5S)-2-(4-Methoxy-phenyl)-4,5-dimethyl-4-(4-methyl-pent-3-enyl)-[1,3]dioxane
  参考文献：
  名称：

  2. Synthesis of the C.14–C.26 hydrophilic domain of amphidinolide B1 and formation of the (E)-1,1′,3-trisubstituted diene sector

  摘要：

  In the preceding letter, we described a synthesis of the conserved C.1-C.13 hydrophobic domain common to the potent B-type amphidinolides. In this letter, we present syntheses of the C.14-C.26 hydrophilic domain specific to amphidinolide B1 and a model for uniting the hydrophobic and hydrophilic domains to form the (E)-1,1',3-trisubstituted diene. (C) 1999 Published by Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(99)00207-5