2-methoxy-4-(methoxylmethoxy)benzyl acetate | 1417423-54-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-methoxy-4-(methoxylmethoxy)benzyl acetate
• 英文别名: [2-Methoxy-4-(methoxymethoxy)phenyl]methyl acetate；[2-methoxy-4-(methoxymethoxy)phenyl]methyl acetate
• CAS: 1417423-54-1
• 化学式: C₁₂H₁₆O₅
• 分子量: 240.256
• InChiKey: NTPKNQGUBIOHQD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  17
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  54
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  1,3,5-三甲氧基苯 、 2-methoxy-4-(methoxylmethoxy)benzyl acetate 在 p-toluenesulfonic acid immobilized on silica 作用下， 以 甲苯 为溶剂， 反应 3.0h， 以56%的产率得到5-methoxy-2,4-bis(2,4,6-trimethoxybenzyl)phenol
  参考文献：
  名称：

  Facile synthesis of diarylmethanes via quinone methides

  摘要：

  A novel acid-mediated generation of quinone methides followed by nucleophilic addition of electron-rich aromatic compounds to furnish diarylmethanes has been developed. A wide range of electron-rich aromatic compounds including some heterocycles can be employed for this reaction to provide the corresponding diarylmethanes in good yields and regioselectivities. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2012.10.087
• 作为产物：
  描述：

  2,4-二羟基苯甲醛 在 4-二甲氨基吡啶 、 sodium tetrahydroborate 、 sodium hydride 、 potassium carbonate 、 三乙胺 作用下， 以 乙醇 、 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 反应 7.0h， 生成 2-methoxy-4-(methoxylmethoxy)benzyl acetate
  参考文献：
  名称：

  Facile synthesis of diarylmethanes via quinone methides

  摘要：

  A novel acid-mediated generation of quinone methides followed by nucleophilic addition of electron-rich aromatic compounds to furnish diarylmethanes has been developed. A wide range of electron-rich aromatic compounds including some heterocycles can be employed for this reaction to provide the corresponding diarylmethanes in good yields and regioselectivities. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2012.10.087

文献信息

• Facile synthesis of diarylmethanes via quinone methides
  作者：Kassrin Tangdenpaisal、Wong Phakhodee、Somsak Ruchirawat、Poonsakdi Ploypradith

  DOI：10.1016/j.tet.2012.10.087

  日期：2013.1

  A novel acid-mediated generation of quinone methides followed by nucleophilic addition of electron-rich aromatic compounds to furnish diarylmethanes has been developed. A wide range of electron-rich aromatic compounds including some heterocycles can be employed for this reaction to provide the corresponding diarylmethanes in good yields and regioselectivities. (C) 2012 Elsevier Ltd. All rights reserved.