3-<(3-Chloropropoxy)methyl>pyridine | 98875-78-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 3-<(3-Chloropropoxy)methyl>pyridine
• 英文别名: 3-(3-Chloropropoxymethyl)pyridine
• CAS: 98875-78-6
• 化学式: C₉H₁₂ClNO
• 分子量: 185.653
• InChiKey: WVJXNKWJJYQRBU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  12
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  22.1
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  3-<(3-Chloropropoxy)methyl>pyridine 、 5,10,15-Tris(2,6-dichlorophenyl)-20-<2-<5-(ethoxycarbonyl)pentyloxy>phenyl>porphyrin 在 caesium carbonate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 96.0h， 以80%的产率得到5,10,15-Tris(2,6-dichlorophenyl)-20-<2-<5-(ethoxycarbonyl)pentyloxy>-6-<3-(3-pyridylmethoxy)propoxy>phenyl>porphyrin
  参考文献：
  名称：

  Anelli, Pier Lucio; Banfi, Stefano; Legramandi, Francesco, Journal of the Chemical Society. Perkin transactions I, 1993, # 12, p. 1345 - 1358

  摘要：

  DOI：
• 作为产物：
  描述：

  3-氯甲基吡啶盐酸盐 、 3-氯-1-丙醇 在 potassium tert-butylate 作用下， 生成 3-<(3-Chloropropoxy)methyl>pyridine
  参考文献：
  名称：

  Highly efficient sodium hypochlorite olefin epoxidations catalyzed by imidazole or pyridine "tailed" manganese porphyrins under two-phase conditions. Influence of pH and of the anchored ligand

  摘要：

  DOI：

  10.1021/jo00224a048

文献信息

• ARYLALKYLOXYALKYLAMINES AND ARYLALKYLTHIOALKYLAMINES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USE AS INHIBITORS OF NICOTINIC CHOLINERGIC RECEPTORS
  申请人：Targacept, Inc.

  公开号：EP1212301A1

  公开（公告）日：2002-06-12
• [EN] ARYLALKYLOXYALKYLAMINES AND ARYLALKYLTHIOALKYLAMINES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USE AS INHIBITORS OF NICOTINIC CHOLINERGIC RECEPTORS<br/>[FR] ARYLALKYLOXYALKYLAMINES ET ARYLALKYLTHIOALKYLAMINES, COMPOSITIONS PHARMACEUTIQUES LES CONTENANT ET LEUR UTILISATION EN TANT QU'INHIBITEURS DES RECEPTEURS CHOLINERGIQUES NICOTINIQUES
  申请人：TARGACEPT INC

  公开号：WO2001016107A1

  公开（公告）日：2001-03-08

  Patients susceptible to or suffering from conditions and disorders, such as central nervous system disorders, are treated by administering to a patient in need arylalkyloxyalkylamine and arylalkylthioalkylamine compounds, including arylmethoxyalkylamines and arylmethylthioalkylamines, such as pyridylmethoxyalkylamines and pyridylmethylthio alkylamines. Exemplary compounds include methyl(3-(3-pyridylmethoxy)propyl)amine, 3-pyridyl(pyrrolidin-2-ylmethoxy)methane, methyl(1-methyl-2-(3-pyridylmethoxy)ethyl)amine, (3-((3-pyridyl)methoxy)propyl)dimethylamine, (2-((5-bromo-3-pyridyl)methoxy)ethyl)methylamine, methyl(2-((5-methoxy-3-pyridyl)methoxy)ethyl)amine, (2-((3-quinolyl)methoxy)ehtyl)methylamine, methyl(2-(pyrimidin-5-ylmethoxy)ethyl)amine, 3-((3-pyridyl)methoxy)quinuclidine, (3-pyridyl)quinuclidin-2-ylmethoxy)methane, (3-pyridyl)(pyrrolidin-2-ylmethylthio)methane and (2-((3-pyridyl)methylthio)ethyl)methylamine.
• Anelli, Pier Lucio; Banfi, Stefano; Legramandi, Francesco, Journal of the Chemical Society. Perkin transactions I, 1993, # 12, p. 1345 - 1358
  作者：Anelli, Pier Lucio、Banfi, Stefano、Legramandi, Francesco、Montanari, Fernando、Pozzi, Gianluca、Quici, Silvio

  DOI：——

  日期：——
• Highly efficient sodium hypochlorite olefin epoxidations catalyzed by imidazole or pyridine "tailed" manganese porphyrins under two-phase conditions. Influence of pH and of the anchored ligand
  作者：Fernando Montanari、Michele Penso、Silvio Quici、Patrizia Vigano

  DOI：10.1021/jo00224a048

  日期：1985.11