11-(乙胺基)十一烷酸 | 7441-35-2

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 中文名称: 11-(乙胺基)十一烷酸
• 英文名称: 11-ethylamino-undecanoic acid
• 英文别名: 11-Aethylamino-undecansaeure；11-(N-Aethyl-amino)-undecansaeure；Undecanoic acid, 11-(ethylamino)-；11-(ethylamino)undecanoic acid
• CAS: 7441-35-2
• 化学式: C₁₃H₂₇NO₂
• 分子量: 229.363
• InChiKey: XMOPBLYWQVTWAR-UHFFFAOYSA-N

物化性质

• 熔点：
  120 °C
• 沸点：
  349.1±15.0 °C(Predicted)
• 密度：
  0.930±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  16
• 可旋转键数：
  12
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.92
• 拓扑面积：
  49.3
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  11-(乙胺基)十一烷酸 在 N-乙基吗啉 、 4-二甲氨基吡啶 、 sodium hydroxide 、 氯化亚砜 、 1-羟基苯并三唑 、 三乙胺 、 N,N'-二环己基碳二亚胺 作用下， 以 二氯甲烷 为溶剂， 反应 8.0h， 生成 Methyl 3-[11-[ethyl(prop-2-enoyl)amino]undecanoylamino]propanoate
  参考文献：
  名称：

  Polyanion Inhibitors of Human Immunodeficiency Virus and Other Viruses. 5. Telomerized Anionic Surfactants Derived from Amino Acids

  摘要：

  omega-Acryloyl anionic surfactants, whose polar heads are derived from amino acids, have been telomerized to prepare polyanions of a predetermined molecular weight. The main goal of this study was to verify whether the antiviral activity is influenced by the degree of polymerization of the polyanions. The oligomeric polyanions were evaluated for their activity against human immunodeficiency virus (HIV-1 or HIV-2) and various other RNA and DNA viruses. With regard to their anti-HIV activity, a minimum number of anionic groups was necessary to achieve an inhibitory effect. Moreover, to be active the overall conformation of the polyanion must be such that the anionic groups are located on the external site of the molecule. With some of the polyanions, a 50% inhibition concentration (IC50) as low as 1 mu g/mL, or even 0.1 mu g/mL, was noted against HIV-1 in CEM-4 and MT-4 cells, respectively. The most potent polyanions also proved active against human cytomegalovirus and herpex simplex virus at concentrations of 5-10 and 20-40 mu g/mL, respectively. No activity was observed against any of the other viruses tested (i.e., vesicular stomatitis, Sindbis, Semliki forest, parainfluenza, Junin, Tacaribe, Coxsackie, polio, reo, and vaccinia). No toxicity for the host cells was observed at concentrations up to 200 mu g/mL.

  DOI：

  10.1021/jm960493b
• 作为产物：
  描述：

  11-溴十一酸 、 乙胺 以 水 为溶剂， 生成 11-(乙胺基)十一烷酸
  参考文献：
  名称：

  Polyanion Inhibitors of Human Immunodeficiency Virus and Other Viruses. 5. Telomerized Anionic Surfactants Derived from Amino Acids

  摘要：

  omega-Acryloyl anionic surfactants, whose polar heads are derived from amino acids, have been telomerized to prepare polyanions of a predetermined molecular weight. The main goal of this study was to verify whether the antiviral activity is influenced by the degree of polymerization of the polyanions. The oligomeric polyanions were evaluated for their activity against human immunodeficiency virus (HIV-1 or HIV-2) and various other RNA and DNA viruses. With regard to their anti-HIV activity, a minimum number of anionic groups was necessary to achieve an inhibitory effect. Moreover, to be active the overall conformation of the polyanion must be such that the anionic groups are located on the external site of the molecule. With some of the polyanions, a 50% inhibition concentration (IC50) as low as 1 mu g/mL, or even 0.1 mu g/mL, was noted against HIV-1 in CEM-4 and MT-4 cells, respectively. The most potent polyanions also proved active against human cytomegalovirus and herpex simplex virus at concentrations of 5-10 and 20-40 mu g/mL, respectively. No activity was observed against any of the other viruses tested (i.e., vesicular stomatitis, Sindbis, Semliki forest, parainfluenza, Junin, Tacaribe, Coxsackie, polio, reo, and vaccinia). No toxicity for the host cells was observed at concentrations up to 200 mu g/mL.

  DOI：

  10.1021/jm960493b

文献信息

• Champetier et al., Bulletin de la Societe Chimique de France, 1958, p. 708,709
  作者：Champetier et al.

  DOI：——

  日期：——
• Champetier; Lavalou, Bulletin de la Societe Chimique de France, 1958, p. 262
  作者：Champetier、Lavalou

  DOI：——

  日期：——
• PARAMAGNETIC CHELATES FOR NUCLEAR MAGNETIC RESONANCE DIAGNOSIS
  申请人：BRACCO S.p.A.

  公开号：EP0731797A1

  公开（公告）日：1996-09-18
• PARTICLES COMPRISING AMPHIPHILIC COPOLYMERS, HAVING A CROSS-LINKED SHELL DOMAIN AND AN INTERIOR CORE DOMAIN, USEFUL FOR PHARMACEUTICAL AND OTHER APPLICATIONS
  申请人：G.D. Searle & Co.

  公开号：EP0910351A1

  公开（公告）日：1999-04-28
• [EN] PARTICLES COMPRISING AMPHIPHILIC COPOLYMERS, HAVING A CROSS-LINKED SHELL DOMAIN AND AN INTERIOR CORE DOMAIN, USEFUL FOR PHARMACEUTICAL AND OTHER APPLICATIONS<br/>[FR] PARTICULES COMPRENANT DES COPOLYMERES AMPHIPHILES, POSSEDANT UN DOMAINE D'ENVELOPPE RETICULEE ET UN DOMAINE DE NOYAU UTILES ET AUTRES DANS DES APPLICATIONS PHARMACEUTIQUES
  申请人：——

  公开号：WO1997049387A1

  公开（公告）日：1997-12-31

  [EN] Provided are particles comprising amphiphilic copolymers, having a cross-linked shell domain and an interior core domain. Also provided are compositions comprising such particles, including pharmaceutical compositions, methods of making the present particles, and methods of using such particles, for example for delivery of pharmaceutically active agents.
  [FR] L'invention concerne des particules comprenant des copolymères amphiphiles, possédant un domaine d'enveloppe réticulé et un domaine de noyau interne. Des compositions sont également décrites qui englobent de telles particules, y compris des compositions pharmaceutiques, des procédés de fabrication des présentes particules et des procédés d'utilisation de telles particules pour l'administation, par exemple, d'agents pharmacologiquement actifs.