norborn-5-ene-2,2-dicarboxylic acid diethyl ester | 65132-76-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: norborn-5-ene-2,2-dicarboxylic acid diethyl ester
• 英文别名: Norborn-5-en-2,2-dicarbonsaeure-diaethylester；2,2-bisethoxycarbonyl-5-norbornene；Diethyl bicyclo[2.2.1]hept-5-ene-2,2-dicarboxylate
• CAS: 65132-76-5
• 化学式: C₁₃H₁₈O₄
• 分子量: 238.284
• InChiKey: QUEDRIDBPKVZKT-UHFFFAOYSA-N

物化性质

• 沸点：
  129-130 °C(Press: 10 Torr)
• 密度：
  1.0952 g/cm3

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  17
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.69
• 拓扑面积：
  52.6
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  norborn-5-ene-2,2-dicarboxylic acid diethyl ester 以55%的产率得到
  参考文献：
  名称：

  PONTICELLO J. S., J. POLYM. SCI.: POLYM. CHEM. ED., 1979, 17, NO 11, 3509-3518

  摘要：

  DOI：
• 作为产物：
  描述：

  甲撑丙二酸二乙酯 、 环戊二烯 在 苯 作用下， 生成 norborn-5-ene-2,2-dicarboxylic acid diethyl ester
  参考文献：
  名称：

  Lewina; Godowikow, Zhurnal Obshchei Khimii, 1955, vol. 25, p. 986,988; engl. Ausg. S. 951

  摘要：

  DOI：

文献信息

• Tricyclic cage compounds, their synthesis and use as antiviral agents
  申请人：Sumitomo Chemical Company, Limited

  公开号：US04347254A1

  公开（公告）日：1982-08-31

  A compound of the formula: ##STR1## wherein A.sub.1 is a single bond or a C.sub.1 -C.sub.5 alkylene group bonding at the 2-, 2'- or 3-position, A.sub.2 is a C.sub.1 -C.sub.3 alkylene group, A.sub.3 is a C.sub.1 -C.sub.4 alkylene group, X is --O-- or --SO.sub.n -- and B is a carboxy group, a C.sub.2 -C.sub.5 alkoxycarbonyl group, a cyano group, an amino group of the formula: ##STR2## or a carbamoyl group of the formula: ##STR3## which is useful as an antiviral agent with no side effect.

  一种化合物，其分子式为：##STR1## 其中A.sub.1是一个单键或C.sub.1-C.sub.5烷基，在2-、2'-或3-位置连接，A.sub.2是一个C.sub.1-C.sub.3烷基，A.sub.3是一个C.sub.1-C.sub.4烷基，X是--O--或--SO.sub.n--，B是一个羧基，一个C.sub.2-C.sub.5烷氧羰基，一个氰基，一个公式为：##STR2## 的氨基或一个公式为：##STR3## 的氨基甲酰基，该化合物是一种无副作用的抗病毒剂。
• Heterotricyclic compounds, processes for their production and pharmaceutical compositions containing them
  申请人：SUMITOMO CHEMICAL COMPANY, LIMITED

  公开号：EP0006283A1

  公开（公告）日：1980-01-09

  A compound of the formula: wherein A, is a single bond or a C1-C5 alkylene group bonding at the 2- or 3-position, A2 is a C1-C4 alkylene group, A3 is a single bond or a C1-C3 alkylene group, X-Y is -O-CH2- -O-CO- or -SOn-CH2- and B is a carboxy group, a C2-C5 alkoxycarbonyl group, a cyano group, a hydroxy group, a C2-C5 acyloxy group, a halogen group, a carbamoyl group of the formula: or an amino group of the formula: The compounds of the invention are useful as antiviral agents against, for example, influenza virus and herpes simplex virus.

  式中的化合物： 其中 A 是单键或键合在 2 位或 3 位的 C1-C5 亚烷基，A2 是 C1-C4 亚烷基，A3 是单键或 C1-C3 亚烷基，X-Y 是 -O-CH2- -O-CO- 或 -SOn- - 和 B 是羧基、C2-C5 烷氧基羰基、氰基、羟基、C2-C5 乙酰氧基、卤素基、式中的氨基甲酰基： 或式中的氨基： 本发明的化合物可用作抗病毒剂，例如抗流感病毒和单纯疱疹病毒。
• Intakes of Selected Nutrients and Food Groups and Risk of Ovarian Cancer
  作者：Susan E. McCann、Kirsten B. Moysich、Curtis Mettlin

  DOI：10.1207/s15327914nc391_3

  日期：2001.1

  In a hospital-based case-control study, we examined dietary intakes of selected nutrients and food groups and ovarian cancer risk among 496 women with primary, histologically confirmed epithelial ovarian cancer and 1,425 women with nonneoplastic diagnoses, ages 20-87 years, admitted to Roswell Park Cancer Institute between 1982 and 1998. Data on diet and other relevant risk factors in the few years before admission were collected with a se administered questionnaire. Odds ratios (OR) and 95% confidence intervals (CI) were estimated by unconditional logistic regression adjusting for age, education, region of residence, regularity of menstruation, family. history of ovarian cancer, parity, age at menarche, oral contraceptive use, and energy intake. Women in the highest vs. the lowest quartile of total energy had a weak increase in risk (OR = 1.25, 95% CI = 0.90-1.73). Significantly reduced risks were associated with higher intakes of dietary fiber (OR = 0.57, 95% CI = 0.38-0.87), vitamin A (OR = 0.66, 95% CI = 0.45-0.98), carotenoid (OR = 0.64, 95% CI = 0.43-0.93), vitamin E (OR = 0.58, 95% CI = 0.38-0.88), beta -carotene (OR = 0.68, 95% CI = 0.46-0.98), and total fruit and vegetable intake (OR = 0.62, 95% CI = 0.42-0.92). Our findings suggest that a diet high in plant foods may be important in reducing risk of ovarian cancer.
• KRAPCHO A. P.; WEIMASTER J. F., J. ORG. CHEM., 1980, 45, NO 21, 4105-4111
  作者：KRAPCHO A. P.、 WEIMASTER J. F.

  DOI：——

  日期：——
• POLYMERIC COMPOSITIONS FOR FORMING OPTICAL WAVEGUIDES; OPTICAL WAVEGUIDES FORMED THEREFROM; AND METHODS FOR MAKING SAME
  申请人：Goodrich Corporation

  公开号：EP1307493A2

  公开（公告）日：2003-05-07