1-methyl-2,3-dihydro-indol-6-ol | 7556-21-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 1-methyl-2,3-dihydro-indol-6-ol
• 英文别名: 1-methyl-indolin-6-ol；N-Methyl-6-hydroxyindoline；1-Methyl-6-hydroxy-indolin；1-Methylindolin-6-ol；1-methyl-2,3-dihydroindol-6-ol
• CAS: 7556-21-0
• 化学式: C₉H₁₁NO
• 分子量: 149.192
• InChiKey: LNWRQPDKMNMPME-UHFFFAOYSA-N

物化性质

• 熔点：
  97 °C (sublm)(Solv: ethyl ether (60-29-7))
• 沸点：
  168-172 °C(Press: 12 Torr)
• 密度：
  1.165±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  11
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  23.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1-methyl-2,3-dihydro-indol-6-ol 在 光气 、 苯 作用下， 生成 diphenyl-carbamic acid-(1-methyl-indolin-6-yl ester)
  参考文献：
  名称：

  US2755287

  摘要：

  公开号：
• 作为产物：
  描述：

  6-羟基-1-甲基-1,3-二氢-2H-吲哚-2-酮 在 lithium aluminium tetrahydride 作用下， 生成 1-methyl-2,3-dihydro-indol-6-ol
  参考文献：
  名称：

  US2755287

  摘要：

  公开号：

文献信息

• NOVEL COMPOUNDS
  申请人：Gottschling Dirk

  公开号：US20110021500A1

  公开（公告）日：2011-01-27

  The present invention relates to new CGRP-antagonists of general formula I wherein U, V, X, Y, R 1 , R 2 , R 3 and R 4 are defined as in the description, the tautomers, the isomers, the diastereomers, the enantiomers, the hydrates, the mixtures thereof and the salts thereof and the hydrates of the salts, particularly the physiologically acceptable salts thereof with inorganic or organic acids or bases, medicaments containing these compounds, their use and processes for preparing them.

  本发明涉及一般式I的新的CGRP拮抗剂，其中U、V、X、Y、R1、R2、R3和R4如描述中所定义，其互变异构体、同分异构体、对映异构体、立体异构体、水合物、其混合物及其盐以及盐的水合物，特别是其与无机或有机酸或碱的生理上可接受的盐，含有这些化合物的药物、它们的用途以及制备它们的方法。
• Preparation of 6-hydroxyindolines and their use for preparation of novel
  申请人：The United States of Americas as represented by the United States

  公开号：US05256799A1

  公开（公告）日：1993-10-26

  A novel method for the synthesis of 6-hydroxyindolines and new fluorescent dyes produced therefrom, which dyes are ring-constrained indoline-based rhodamine class dyes. These dyes have absorption and emission spectra which make them particularly useful in certain dye laser applications.

  一种合成6-羟基吲哚啉和由此产生的新荧光染料的新方法，这些染料是基于环限制吲哚啉的罗丹明类染料。这些染料具有吸收和发射光谱，使它们在某些染料激光应用中特别有用。
• [EN] COMPOUNDS AS RAS INHIBITORS AND USES THEREOF<br/>[FR] COMPOSÉS EN TANT QU'INHIBITEURS DE RAS ET LEURS UTILISATIONS
  申请人：BIOARDIS LLC

  公开号：WO2022087624A1

  公开（公告）日：2022-04-28

  The present disclosure relates generally to compounds and compositions thereof for inhibition of RAS, such as KRAS, HRAS and NRAS, including mutant forms of KRAS, HRAS and NRAS, particularly those harboring a G12C mutation, methods of preparing said compounds and compositions, and their use in the treatment or prophylaxis of various cancers, such as lung cancer, colorectal cancer, pancreatic cancer, gall bladder cancer, thyroid cancer, and bile duct cancer.

  本公开涉及抑制RAS的化合物和其组成物，例如KRAS、HRAS和NRAS，包括带有G12C突变的KRAS、HRAS和NRAS的突变形式，制备这些化合物和组合物的方法，以及它们在治疗或预防各种癌症方面的用途，例如肺癌、结直肠癌、胰腺癌、胆囊癌、甲状腺癌和胆管癌。
• Composition for dyeing human hair
  申请人：KPSS-Kao Professional Salon Services GmbH

  公开号：EP1559403A1

  公开（公告）日：2005-08-03

  This invention relates to a hair dyeing composition comprising direct acting hair dyes and showing excellent dyeing effects. It should be well understood that the colouring composition of this invention are ready to use colouring composition and, therefore, do not require any mixing prior to application with additional agents such as oxidizers. In another way of carrying out the invention and in the case that a brightening and lightening, in hair colour, is wished (highlighting effect) the compositions of the present invention can as well be used after mixing with oxidizing agent.

  本发明涉及一种染发组合物，它由直接作用的染发剂组成，并显示出卓越的染色效果。应充分理解的是，本发明的染发组合物是即用型染发组合物，因此在使用前无需与氧化剂等附加剂混合。在实施本发明的另一种方法中，如果希望使头发颜色变亮和变浅（提亮效果），本发明的组合物也可以在与氧化剂混合后使用。
• Composition for bleaching and dyeing keratin fibres
  申请人：KPSS-Kao Professional Salon Services GmbH

  公开号：EP1598052A1

  公开（公告）日：2005-11-23

  The composition of the present invention is a two part agent which are to be mixed homogeneously prior to application onto hair, preferably as well with an agent comprising at least one oxidizing agent, comprising a water-free composition being part A which comprises at least one compound with bleaching and/or brightening effect and an aqueous composition being Part B comprising at least one direct acting anionic dyestuff and at least one direct acting cationic dyestuff. The compositions of the present invention show excellent colouring and bleaching effects and the achieved colorations are excellently stable against washing (shampooing) and environmental influences. Cationic dyestuff preferred are according to the general formula I to iV below. and wherein R1, R2, R3 and R4 stand for hydrogen, a CH3- or C2H5- group, R5 stands for hydrogen, -OCH3 or -OC2H5 and Y is an anion such as chloride, bromide, methosulfate.

  本发明的组合物是一种双组分制剂，在涂抹到头发上之前要均匀混合，最好也与一种包含至少一种氧化剂的制剂混合，包括一种无水组合物（A 部分），其中包含至少一种具有漂白和/或增亮效果的化合物，以及一种含水组合物（B 部分），其中包含至少一种直接作用阴离子染料和至少一种直接作用阳离子染料。本发明的组合物具有极佳的染色和漂白效果，并且所获得的染色效果在洗涤（洗发）和环境影响下非常稳定。阳离子染料最好符合以下通式 I 至 iV。 和 其中 R1、R2、R3 和 R4 代表氢、CH3- 或 C2H5-，R5 代表氢、-OCH3 或 -OC2H5，Y 是阴离子，如氯化物、溴化物、甲硫酸盐。