(R)-2-(2-pyridyl)propyl p-toluenesulfonate | 194228-35-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (R)-2-(2-pyridyl)propyl p-toluenesulfonate
• CAS: 194228-35-8
• 化学式: C₁₅H₁₇NO₃S
• 分子量: 291.371
• InChiKey: VKLNRGAZLJYNAF-ZDUSSCGKSA-N

物化性质

• 沸点：
  438.2±33.0 °C(Predicted)
• 密度：
  1.206±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  20.0
• 可旋转键数：
  5.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  56.26
• 氢给体数：
  0.0
• 氢受体数：
  4.0

反应信息

• 作为反应物：
  描述：

  甲基锂 、 (R)-2-(2-pyridyl)propyl p-toluenesulfonate 在 copper(l) iodide 作用下， 生成 (+)-(S)-2-(1-methylpropyl)pyridine
  参考文献：
  名称：

  Enzyme catalysed asymmetrization of pyridyl substituted 1,3-propanediols and of the corresponding diacetates

  摘要：

  2-(4-pyridyl)- and 2-(2-pyridyl)-1,3-propanediols 1 and 4 were prepared and asymmetrized by enantioselective acetylation in organic solvent catalysed by hydrolytic enzymes, the best being supported pig pancreatic lipase, to give new valuable heterocyclic chiral building blocks. The asymmetrization of diacetate 6, catalysed by pig pancreatic lipase is also described. (C) 1997 Elsevier Science Ltd.

  DOI：

  10.1016/s0957-4166(97)00218-8
• 作为产物：
  描述：

  (R)-3-(acetoxy)-2-(2-pyridyl)propan-1-ol 在 吡啶 、 咪唑 、 氢氧化钾 、 四丁基氟化铵 、 三乙基硼氢化锂 、 三乙胺 作用下， 以 四氢呋喃 、 甲醇 、 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 反应 11.67h， 生成 (R)-2-(2-pyridyl)propyl p-toluenesulfonate
  参考文献：
  名称：

  Enzyme catalysed asymmetrization of pyridyl substituted 1,3-propanediols and of the corresponding diacetates

  摘要：

  2-(4-pyridyl)- and 2-(2-pyridyl)-1,3-propanediols 1 and 4 were prepared and asymmetrized by enantioselective acetylation in organic solvent catalysed by hydrolytic enzymes, the best being supported pig pancreatic lipase, to give new valuable heterocyclic chiral building blocks. The asymmetrization of diacetate 6, catalysed by pig pancreatic lipase is also described. (C) 1997 Elsevier Science Ltd.

  DOI：

  10.1016/s0957-4166(97)00218-8

文献信息

• Enzyme catalysed asymmetrization of pyridyl substituted 1,3-propanediols and of the corresponding diacetates
  作者：Giuseppe Guanti、Enrica Narisano、Renata Riva

  DOI：10.1016/s0957-4166(97)00218-8

  日期：1997.7

  2-(4-pyridyl)- and 2-(2-pyridyl)-1,3-propanediols 1 and 4 were prepared and asymmetrized by enantioselective acetylation in organic solvent catalysed by hydrolytic enzymes, the best being supported pig pancreatic lipase, to give new valuable heterocyclic chiral building blocks. The asymmetrization of diacetate 6, catalysed by pig pancreatic lipase is also described. (C) 1997 Elsevier Science Ltd.