2-(2-methoxyphenoxy)propan-1-amine | 6440-87-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 2-(2-methoxyphenoxy)propan-1-amine
• 英文别名: 2-(2-methoxy-phenoxy)propylamine；1-[(1-Aminopropan-2-YL)oxy]-2-methoxybenzene
• CAS: 6440-87-5
• 化学式: C₁₀H₁₅NO₂
• mdl: MFCD07374159
• 分子量: 181.235
• InChiKey: BIWHLVXMIXGLJA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  13
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  44.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-(2-methoxyphenoxy)propan-1-amine 、 4-环氧丙烷氧基咔唑 以83%的产率得到1-[carbazolyl-(4)-oxy]-3-[2-(2-methoxyphenoxy)-propylamino]-propan-2-ol
  参考文献：
  名称：

  Carbazolyl-(4)-oxypropanolamine compounds and therapeutic compositions

  摘要：

  Carbazolyl-(4)-oxypropanolamine化合物的化学式为##STR1##其中R.sub.1是氢，较低的烷酰基或芳酰基；R.sub.2是氢，较低的烷基或芳基烷基；R.sub.3是氢或较低的烷基；R.sub.4是氢或较低的烷基，或者当X是氧时，R.sub.4与R.sub.5一起可以代表--CH.sub.2--O--；X是一个价键，--CH.sub.2--，氧或硫；Ar是单环或双环芳基或吡啶基；R.sub.5和R.sub.6分别选自氢，卤素，羟基，较低的烷基，氨基甲酰基，较低的烷氧基，芳基烷氧基，较低的烷基硫基，较低的烷基磺基；R.sub.5和R.sub.6一起可以代表亚甲二氧基；以及它们与生理上可接受的酸盐在治疗和预防循环和心脏疾病，例如高血压和心绞痛方面具有卓越的疗效。

  公开号：

  US04503067A1
• 作为产物：
  描述：

  2-(2-methoxyphenoxy)propanamide 在 lithium aluminium tetrahydride 作用下， 以 四氢呋喃 为溶剂， 以20%的产率得到2-(2-methoxyphenoxy)propan-1-amine
  参考文献：
  名称：

  Design, synthesis, and pharmacological effects of structurally simple ligands for MT1 and MT2 melatonin receptors

  摘要：

  A series of phenoxyalkyl and phenylthioalkyl amides were prepared as melatoninergic ligands. Modulation of affinity of the newly synthesized compound by applying SARs around the terminal amide moiety, the alkyl chain, and the methoxy group on the aromatic ring provides compounds with nanomolar affinity for both melatonin receptor subtypes. Affinity towards MT1 and MT2 receptors were modulated also exploiting chirality. The investigation of intrinsic activity revealed that all the tested compounds behave as full or partial agonists. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2010.06.100

文献信息

• N-aryloxyethyl-indoly-alkylamines for the treatment of depression
  申请人：American Home Products Corp.

  公开号：US06121307A1

  公开（公告）日：2000-09-19

  Compounds useful for alleviating symptoms of depression are provided which have the following formula: wherein: R.sub.1 is hydrogen, lower alkyl or aryl; R.sub.2 is hydrogen, lower alkyl, phenyl or substituted phenyl; X and Y are each, independently, hydrogen, lower alkyl, lower alkoxy, or halogen, or together combine with the carbon atoms to which they are attached to complete a pyranyl, dihydrofuranyl, furanyl, or dioxanyl, group; Z is hydrogen, halogen or lower alkoxy; with the proviso that when X, Y or Z represent lower alkoxy, they are not present at the ortho position; W is hydrogen, halogen, lower alkyl, cyano or a trifluoromethyl group; and n is 2-5; or pharmaceutically acceptable salts thereof.

  提供了用于缓解抑郁症症状的化合物，其具有以下结构式：其中：R.sub.1为氢、低碳基或芳基；R.sub.2为氢、低碳基、苯基或取代苯基；X和Y分别独立地为氢、低碳基、低烷氧基或卤素，或者与它们连接的碳原子结合在一起形成吡喃基、二氢呋喃基、呋喃基或二氧杂环基；Z为氢、卤素或低烷氧基；但当X、Y或Z代表低烷氧基时，它们不位于邻位；W为氢、卤素、低碳基、氰基或三氟甲基基团；n为2-5；或其药用盐。
• N-arloxyethyl-alkylamines for the treatment of depression
  申请人：American Home Products Corp

  公开号：US06291683B1

  公开（公告）日：2001-09-18

  Compounds useful for alleviating symptoms of depression are provided which have the following formula: wherein: R1 is hydrogen, lower alkyl or aryl; R2 is hydrogen, lower alkyl, phenyl or substituted phenyl; X and Y are each, independently, hydrogen, lower alkyl, lower alkoxy, or halogen, or together combine with the carbon atoms to which they are attached to complete a cyclopentyl, cyclohexyl, phenyl, pyrrolyl, pyranyl, pyridinyl, dihydrofuranyl, furanyl, dioxanyl, oxazolyl or isoxazolyl group; Z is hydrogen, halogen or lower alkoxy; with the proviso that when X, Y or Z represent lower alkoxy, they are not present at the ortho position; W is hydrogen, halogen, lower alkyl, cyano or a trifluoromethyl group; and n is 2-5; or pharmaceutically acceptable salts thereof.

  提供了用于缓解抑郁症状的化合物，其具有以下结构式：其中：R1为氢、低级烷基或芳基；R2为氢、低级烷基、苯基或取代苯基；X和Y各自独立地为氢、低级烷基、低级烷氧基或卤素，或者结合它们所连接的碳原子以完成环戊基、环己基、苯基、吡咯基、吡喃基、吡啶基、二氢呋喃基、呋喃基、二氧杂环己基、噁唑基或异噁唑基；Z为氢、卤素或低级烷氧基；但当X、Y或Z表示低级烷氧基时，它们不出现在邻位；W为氢、卤素、低级烷基、氰基或三氟甲基基团；n为2-5；或其药学上可接受的盐。
• Carbazolyl-(4)-oxy-propanolamin-Derivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
  申请人：BOEHRINGER MANNHEIM GMBH

  公开号：EP0004920A1

  公开（公告）日：1979-10-31

  Die Erfindung betrifft neue Carbazolyl-(4)-oxy- propanolamin-Derivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel. Die Herstellung der erfindungsgemässen Verbindungen erfolgt entweder durch Umsetzen von 4-Propoxy-carbazol-Derivaten mit substituierten Alkylaminen oder durch Reaktion von 4-(3-Aminopropoxy)-carbazol-Derivaten mit reaktiven substituierten Äthan-Derivaten, Aldehyden bzw. Ketonen oder Carbonsäurederivaten.

  本发明涉及新的咔唑基-(4)-氧基丙醇胺衍生物、其制备工艺和含有这些化合物的药物。 根据本发明的化合物是通过 4-丙氧基-咔唑衍生物与取代的烷基胺反应，或通过 4-（3-氨基丙氧基）-咔唑衍生物与反应性取代的乙烷衍生物、醛或酮或羧酸衍生物反应而制备的。
• N-ARYLOXYETHYL-INDOLY-ALKYLAMINES FOR THE TREATMENT OF DEPRESSION (5-HT1A RECEPTOR ACTIVE AGENTS)
  申请人：AMERICAN HOME PRODUCTS CORPORATION

  公开号：EP1070050A1

  公开（公告）日：2001-01-24
• IMIDAZO[4,5-b]PYRIDINE DERIVATIVES, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
  申请人：LES LABORATOIRES SERVIER

  公开号：US20180273528A1

  公开（公告）日：2018-09-27

  Compounds of formula (I): wherein R 1 , R 2 , R 3 , R 4 , and R 5 are as defined in the description. Medicinal products containing the same which are useful in treating cancer, neurodegenerative disorders and metabolic disorders.