2-allyloxy-4-chloromethyl-1-methoxy-benzene | 329008-88-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-allyloxy-4-chloromethyl-1-methoxy-benzene
• 英文别名: 2-Allyloxy-4-chlormethyl-1-methoxy-benzol；2-Allyloxy-4-chloromethyl-1-methoxybenzene；4-(chloromethyl)-1-methoxy-2-prop-2-enoxybenzene
• CAS: 329008-88-0
• 化学式: C₁₁H₁₃ClO₂
• 分子量: 212.676
• InChiKey: BYCWTVCBFAYSLR-UHFFFAOYSA-N

物化性质

• 沸点：
  301.1±32.0 °C(Predicted)
• 密度：
  1.100±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  14
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-allyloxy-4-chloromethyl-1-methoxy-benzene 在 sodium hydroxide 作用下， 生成 acetylamino-(3-allyloxy-4-methoxy-benzyl)-malonic acid monoethyl ester
  参考文献：
  名称：

  Synthetische Versuche in der Morphinreihe

  摘要：

  DOI：

  10.1007/bf00900793
• 作为产物：
  描述：

  3-羟基-4-甲氧基苯甲醇 在 吡啶 、 氯化亚砜 、 potassium carbonate 、 丙酮 作用下， 生成 2-allyloxy-4-chloromethyl-1-methoxy-benzene
  参考文献：
  名称：

  Synthetische Versuche in der Morphinreihe

  摘要：

  DOI：

  10.1007/bf00900793

文献信息

• Macrocyclic Compounds Useful as Bace Inhibitors
  申请人：Betschart Claudia

  公开号：US20080132477A1

  公开（公告）日：2008-06-05

  The invention relates to novel macrocyclic compounds of the formula (I), in which all of the variables are as defined in the specification, the number of ring atoms included in the macrocyclic ring being 14, 15, 16 or 17, in free base form or in acid addition salt form, to their preparation, to their use as medicaments and to medicaments comprising them.

  本发明涉及具有公式(I)的新型大环化合物，其中所有变量如说明书中所定义，大环环中包含的环原子数为14、15、16或17，以自由碱形式或酸加成盐形式存在，以及它们的制备方法、作为药物的使用以及包含它们的药物。
• [EN] MACROCYCLIC PURINES FOR THE TREATMENT OF VIRAL INFECTIONS<br/>[FR] PURINES MACROCYCLIQUES DESTINÉES AU TRAITEMENT D'INFECTIONS VIRALES
  申请人：JANSSEN R & D IRELAND

  公开号：WO2014009509A1

  公开（公告）日：2014-01-16

  This invention relates macrocyclic purine derivatives having formula (I), processes for their preparation, pharmaceutical compositions, and their use in treating viral infections.

  这项发明涉及具有式(I)的大环嘌呤衍生物，其制备方法，药物组合物以及它们在治疗病毒感染中的应用。
• METHOD FOR PRODUCING A HIGH-PURITY AROMATIC METHYL ALCOHOL AND HIGH-PURITY AROMATIC METHYL ALCOHOL COMPOSITION HAVING EXCELLENT PRESERVATION STABILITY
  申请人：Doi Takashi

  公开号：US20120323021A1

  公开（公告）日：2012-12-20

  An object of the present invention is to provide a high-purity aromatic methyl alcohol compound having reduced a bis(arylmethyl)ether compound as a side product mixed thereinto and a high-purity aromatic methyl alcohol composition having excellent preservation stability and methods for producing them. The object of the present invention is achieved by a method for producing a high-purity aromatic methyl alcohol compound, which comprises obtaining a high-purity aromatic methyl alcohol compound in high yield from an aromatic methyl alcohol-containing crude product by subjecting the crude product to distillation in the presence of an anti-decomposition agent. Further, the object for the preservation stability is achieved by producing a high-purity aromatic methyl alcohol composition using the obtained high-purity aromatic methyl alcohol compound.

  本发明的目的是提供一种高纯度芳香基甲醇化合物，其中混有减少的双(芳基甲基)醚化合物作为副产物，并且具有良好的保存稳定性的高纯度芳香基甲醇组合物及其生产方法。本发明的目的通过以下方法实现：通过在抗分解剂的存在下对含芳香基甲醇的原始产品进行蒸馏，从而高产率地获得高纯度芳香基甲醇化合物。此外，通过使用获得的高纯度芳香基甲醇化合物生产高纯度芳香基甲醇组合物，实现了保存稳定性的目标。
• METHOD FOR PRODUCING HIGH PURITY AROMATIC METHYL ALCOHOL, AND HIGH PURITY AROMATIC METHYL ALCOHOL COMPOSITION HAVING EXCELLENT STORAGE STABILITY
  申请人：Ube Industries, Ltd.

  公开号：EP2540695A1

  公开（公告）日：2013-01-02

  An object of the present invention is to provide a high-purity aromatic methyl alcohol compound having reduced a bis(arylmethyl) ether compound as a side product mixed thereinto and a high-purity aromatic methyl alcohol composition having excellent preservation stability and methods for producing them. The object of the present invention is achieved by a method for producing a high-purity aromatic methyl alcohol compound, which comprises obtaining a high-purity aromatic methyl alcohol compound in high yield from an aromatic methyl alcohol-containing crude product by subjecting the crude product to distillation in the presence of an anti-decomposition agent. Further, the object for the preservation stability is achieved by producing a high-purity aromatic methyl alcohol composition using the obtained high-purity aromatic methyl alcohol compound.

  本发明的目的是提供一种高纯度芳香族甲醇化合物，其中混有作为副产物的还原双(芳基甲基)醚化合物，以及一种具有优异保存稳定性的高纯度芳香族甲醇组合物及其生产方法。 本发明的目的是通过一种生产高纯度芳香族甲醇化合物的方法来实现的，该方法包括在有抗分解剂存在的情况下，通过对含芳香族甲醇的粗产品进行蒸馏，以高产率从该粗产品中获得高纯度芳香族甲醇化合物。此外，通过使用所获得的高纯度芳香族甲醇化合物生产高纯度芳香族甲醇组合物，还可实现防腐稳定性的目标。
• Macrocyclic purines for the treatment of viral infections
  申请人：Janssen Sciences Ireland UC

  公开号：US10280180B2

  公开（公告）日：2019-05-07

  This invention relates macrocyclic purine derivatives, processes for their preparation, pharmaceutical compositions, and their use in treating viral infections.

  本发明涉及大环嘌呤衍生物、其制备工艺、药物组合物及其在治疗病毒感染中的用途。