6-氨基-5,6,7,8-四氢萘-2-醇 | 70312-01-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 四氢化萘
• 中文名称: 6-氨基-5,6,7,8-四氢萘-2-醇
• 英文名称: 2-amino-1,2,3,4-tetrahydro-6-hydroxynaphthalene
• 英文别名: 6-OH-AT；6-amino-5,6,7,8-tetrahydro-2-naphthalenol；2-amino-6-hydroxytetralin；2-Amino-6-hydroxy-1,2,3,4-tetrahydronaphthalene；6-Amino-5,6,7,8-tetrahydronaphthalen-2-OL
• CAS: 70312-01-5；70312-03-7
• 化学式: C₁₀H₁₃NO
• mdl: MFCD08236747
• 分子量: 163.219
• InChiKey: QXGFZXONNHGLNR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  12
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  46.2
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  6-氨基-5,6,7,8-四氢萘-2-醇 、 愈创木酚缩水甘油醚 以 盐酸 、 乙醇 、 异丙醇 、 丙酮 为溶剂， 生成 N-(6-hydroxy-1,2,3,4-tetrahydronaphth-2-yl)-2-hydroxy-3-(2-methoxyphenoxy)propanamine hydrochloride
  参考文献：
  名称：

  Aryloxypropanolaminotetralins, a process for their preparation and

  摘要：

  具有β-阻断活性的芳氧基丙醇胺四氢萘，其通式为##STR1##，其中R为氢、羟基或甲氧基，Ar为可选择性取代的芳香或杂芳香基团，以光学活性或非活性形式及其酸加成盐被描述。它们的制备方法以及含有通式(i)化合物或其药学上可接受的酸加成盐的药物组合物也被描述。

  公开号：

  US05254595A1
• 作为产物：
  描述：

  N-benzyl-6-methoxy-1,2,3,4-tetrahydro-2-naphthalenylideneamine 在 palladium on activated charcoal 氢气 、 氢溴酸 作用下， 以 四氢呋喃 、 乙醇 为溶剂， 20.0 ℃ 、344.75 kPa 条件下， 反应 16.0h， 生成 6-氨基-5,6,7,8-四氢萘-2-醇
  参考文献：
  名称：

  A New Series of Estrogen Receptor Modulators That Display Selectivity for Estrogen Receptor β

  摘要：

  A series of 1,3,5-triazine-based estrogen receptor (ER) modulators that are modestly selective for the ERbeta subtype are reported. Compound 1, which displayed modest potency and selectivity for ERbeta vs ERalpha, was identified via high-throughput screening utilizing an ERbeta SPA-based binding assay. Subsequent analogue preparation resulted in the identification of compounds such as 21 and 43 that display 25- to 30-fold selectivity for ERbeta with potencies in the 10-30 nM range. These compounds profile as full antagonists at ERbeta and weak partial agonists at ERalpha in a cell-based reporter gene assay. In addition, the X-ray crystal structure of compound 15 complexed with the ligand binding domain of ERbeta has been solved and was utilized in the design of more conformationally restrained analogues such as 31 in an attempt to increase selectivity for the ERbeta subtype.

  DOI：

  10.1021/jm020291h

文献信息

• [EN] PYRIMIDINE AMIDE COMPOUNDS<br/>[FR] COMPOSÉS PYRIMIDINE AMIDE
  申请人：HOFFMANN LA ROCHE

  公开号：WO2012123467A1

  公开（公告）日：2012-09-20

  Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of inflammatory diseases and disorders such as, for example, asthma and COPD.

  本文提供的化合物为式(I)的化合物及其药学上可接受的盐，其中取代基如规范中所披露的那样。这些化合物及含有它们的药物组合物对于治疗炎症性疾病和紊乱，例如哮喘和慢性阻塞性肺病（COPD）等，具有实用性。
• 1,2,3,4-Tetrahydro-2-piperazinyl-naphthalenes for treating hypertension
  申请人：Sandoz Ltd.

  公开号：US04308266A1

  公开（公告）日：1981-12-29

  The present invention provides tetraline derivatives, useful for the treatment of hypertension, a process for their preparation and compositions containing these compounds.

  本发明提供了四氢萘衍生物，用于治疗高血压，以及它们的制备方法和含有这些化合物的组合物。
• Bicyclic fibrinogen antagonists
  申请人：SmithKline Beecham Corporation

  公开号：US06117910A1

  公开（公告）日：2000-09-12

  This invention relates to compounds of the formula: ##STR1## which are effective for inhibiting platelet aggregation, pharmaceutical compositions for effecting such activity, and a method for inhibiting platelet aggregation.

  这项发明涉及以下化合物的公式：##STR1## 这些化合物对抑制血小板聚集具有有效作用，用于实现此类活性的药物组合物，以及抑制血小板聚集的方法。
• Novel aminotransferase, gene encoding the same, and method of using them
  申请人：Ito Noriyuki

  公开号：US20100285544A1

  公开（公告）日：2010-11-11

  The invention relates to a novel aminotransferase, DNA encoding the enzyme, a recombinant vector into which the DNA has been introduced, and a transformant into which the vector has been introduced. Further, the invention also relates to a method for producing an optically active amino compound utilizing the enzyme or transformant. The aminotransferase of the invention has an ability of efficiently converting a ketone compound, particularly a cyclic ketone compound to an optically active amino compound. According to the invention, a method for efficiently producing an optically active amino compound, particularly an optically active cyclic amino compound is provided.

  本发明涉及一种新型氨基转移酶、编码该酶的DNA、已引入该DNA的重组载体以及已引入该载体的转化菌株。此外，本发明还涉及一种利用该酶或转化菌株生产光学活性氨基化合物的方法。本发明的氨基转移酶能够高效地将酮类化合物，尤其是环状酮类化合物转化为光学活性氨基化合物。根据本发明，提供了一种高效生产光学活性氨基化合物，尤其是光学活性环状氨基化合物的方法。
• NOVEL AMINOTRANSFERASE, GENE ENCODING THE SAME, AND METHODS OF USING THEM
  申请人：ITO NORIYUKI

  公开号：US20120164724A1

  公开（公告）日：2012-06-28

  The invention relates to a novel aminotransferase, DNA encoding the enzyme, a recombinant vector into which the DNA has been introduced, and a transformant into which the vector has been introduced. Further, the invention also relates to a method for producing an optically active amino compound utilizing the enzyme or transformant. The aminotransferase of the invention has an ability of efficiently converting a ketone compound, particularly a cyclic ketone compound to an optically active amino compound. According to the invention, a method for efficiently producing an optically active amino compound, particularly an optically active cyclic amino compound is provided.

  本发明涉及一种新型氨基转移酶、编码该酶的DNA、将该DNA引入的重组载体以及将该载体引入的转化体。此外，本发明还涉及利用该酶或转化体生产光学活性氨基化合物的方法。本发明中的氨基转移酶能够有效地将酮化合物，特别是环状酮化合物转化为光学活性氨基化合物。根据本发明，提供了一种有效生产光学活性氨基化合物，特别是光学活性环状氨基化合物的方法。