trimethyl(2-{3,8,13-trimethoxy-7,12-bis[2-(trimethylsilyl)ethynyl]-10,15-dihydro-5H-tribenzo[a,d,g]cyclononen-2-yl}ethynyl)silane | 1412847-44-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: trimethyl(2-{3,8,13-trimethoxy-7,12-bis[2-(trimethylsilyl)ethynyl]-10,15-dihydro-5H-tribenzo[a,d,g]cyclononen-2-yl}ethynyl)silane
• CAS: 1412847-44-9
• 化学式: C₃₉H₄₈O₃Si₃
• 分子量: 649.065
• InChiKey: JUWOFWQFOINNPR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.48
• 重原子数：
  45.0
• 可旋转键数：
  3.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  27.69
• 氢给体数：
  0.0
• 氢受体数：
  3.0

反应信息

• 作为反应物：
  描述：

  trimethyl(2-{3,8,13-trimethoxy-7,12-bis[2-(trimethylsilyl)ethynyl]-10,15-dihydro-5H-tribenzo[a,d,g]cyclononen-2-yl}ethynyl)silane 在 sodium L-ascorbate 、 四丁基氟化铵 、 copper(II) sulfate 作用下， 以 四氢呋喃 、 水 、 二甲基亚砜 为溶剂， 反应 48.0h， 生成 1-phenyl-4-[3,8,13-trimethoxy-7,12-bis(1-phenyl-1H-1,2,3-triazol-4-yl)-10,15-dihydro-5H-tribenzo[a,d,g]cyclononen-2-yl]-1H-1,2,3-triazole
  参考文献：
  名称：

  Development of Functionalized Cyclotriveratrylene Analogues: Introduction of Withdrawing and π-Conjugated Groups

  摘要：

  Cyclotriveratrylene analogues (CTVs) are supramolecular bowl-shaped molecules known for their ability to complex organic and organometallic guests, to form liquid crystals, polymers, or nanostructures. In this Article, we report the synthesis of new cyclotriveratrylene analogues with fluorescence properties in which various electron-withdrawing or pi-extended conjugated groups are appended to the wide rim ortho to the methoxy-donating groups. Synthetically, these functionalized CTVs cannot be obtained as CTVs with electron-rich functions by the typical method (i.e., the trimerization of the corresponding benzyl alcohol) but are prepared from a common key intermediate, the C-3-triiodocyclotriveratrylene (CTV-I-3), in good yields. Despite the synthetic difficulties encountered due to the presence of three reactive centers, we have demonstrated the possibility of performing Sonogashira coupling and Huisgen cycloaddition reactions directly to the CTV core for the first time. CTVs with pi-extended conjugated groups reveal interesting fluorescence profiles. More broadly, this study utilizes CTV-I-3 to introduce novel functionalities into CTVs to keep exploring their potential applications.

  DOI：

  10.1021/jo301183b
• 作为产物：
  描述：

  (+/-)-2,7,12-triiodo-3,8,13-trimethoxy-10,15-dihydro-5H-tribenzocyclononene 、 三甲基乙炔基硅 在 bis-triphenylphosphine-palladium(II) chloride 、 copper(l) iodide 、 三乙胺 作用下， 以 甲苯 为溶剂， 反应 48.0h， 以77%的产率得到trimethyl(2-{3,8,13-trimethoxy-7,12-bis[2-(trimethylsilyl)ethynyl]-10,15-dihydro-5H-tribenzo[a,d,g]cyclononen-2-yl}ethynyl)silane
  参考文献：
  名称：

  Development of Functionalized Cyclotriveratrylene Analogues: Introduction of Withdrawing and π-Conjugated Groups

  摘要：

  Cyclotriveratrylene analogues (CTVs) are supramolecular bowl-shaped molecules known for their ability to complex organic and organometallic guests, to form liquid crystals, polymers, or nanostructures. In this Article, we report the synthesis of new cyclotriveratrylene analogues with fluorescence properties in which various electron-withdrawing or pi-extended conjugated groups are appended to the wide rim ortho to the methoxy-donating groups. Synthetically, these functionalized CTVs cannot be obtained as CTVs with electron-rich functions by the typical method (i.e., the trimerization of the corresponding benzyl alcohol) but are prepared from a common key intermediate, the C-3-triiodocyclotriveratrylene (CTV-I-3), in good yields. Despite the synthetic difficulties encountered due to the presence of three reactive centers, we have demonstrated the possibility of performing Sonogashira coupling and Huisgen cycloaddition reactions directly to the CTV core for the first time. CTVs with pi-extended conjugated groups reveal interesting fluorescence profiles. More broadly, this study utilizes CTV-I-3 to introduce novel functionalities into CTVs to keep exploring their potential applications.

  DOI：

  10.1021/jo301183b