1-(benzyloxy)-3-(2-bromoethoxy)benzene | 331745-97-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 1-(benzyloxy)-3-(2-bromoethoxy)benzene
• 英文别名: 2-(3-benzyloxyphenoxy)ethyl bromide；1-(2-bromoethoxy)-3-phenylmethoxybenzene
• CAS: 331745-97-2
• 化学式: C₁₅H₁₅BrO₂
• 分子量: 307.187
• InChiKey: YEDPHLFWZIQRLT-UHFFFAOYSA-N

物化性质

• 沸点：
  180-185 °C(Press: 0.4 Torr)
• 密度：
  1.348±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  18
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1-(benzyloxy)-3-(2-bromoethoxy)benzene 在 palladium 10% on activated carbon 、 氢气 作用下， 以 四氢呋喃 、 乙醇 为溶剂， 反应 10.0h， 以91%的产率得到3-(2-bromoethoxy)phenol
  参考文献：
  名称：

  Redox responsive Pd(ii) templated rotaxane nanovalve capped mesoporous silica nanoparticles: a folic acid mediated biocompatible cancer-targeted drug delivery system

  摘要：

  在这里，设计了一种氧化还原响应的Pd(II)模板化轮烷纳米阀盖的介孔硅纳米颗粒，用于有效的针对癌症的药物传递系统。

  DOI：

  10.1039/c4tb01030b

文献信息

• [EN] COMPOUNDS FOR TREATMENT OF ANGIOGENESIS-MEDIATED DISEASES<br/>[FR] COMPOSÉS POUR TRAITER DES MALADIES MÉDIÉES PAR L'ANGIOGENÈSE
  申请人：UNIV INDIANA RES & TECH CORP

  公开号：WO2014182695A1

  公开（公告）日：2014-11-13

  Synthetic cremastranone and cremastranone analogs are disclosed. Additionally, methods for synthesizing cremastranone and cremastranone analogs are disclosed. Methods of treating ocular neovascularization disorders and treating angiogenesis-mediated disease are also disclosed.

  披露了合成克雷马斯特罗内和克雷马斯特罗内类似物。此外，还披露了合成克雷马斯特罗内和克雷马斯特罗内类似物的方法。还披露了治疗眼部新生血管疾病和治疗血管生成介导的疾病的方法。
• [EN] Substituted urea-octatydroindols as antagonists of melanin concentrating hormone receptor 1 (MCH1R)<br/>[FR] UREE-OCTAHYDROINDOLES SUBSTITUES UTILISES EN TANT QU'ANTAGONISTES DU RECEPTEUR 1 DE L'HORMONE CONCENTRANT LA MELANINE (MCH1R)
  申请人：BIOVITRUM AB

  公开号：WO2005051381A1

  公开（公告）日：2005-06-09

  The invention relates to compounds of the general formula (I) wherein R0, R1, R2, R3, R4, R5, R6, R7, R8, R9, Ar, and X are as defined in the description, or a pharmaceutically acceptable salt, hydrates, geometrical isomers, racemates, tautomers, optical isomers, N-oxides and prodrug forms thereof. The compounds may be used for the treatment or prophylaxis of disorders related to the MCH1R receptor and for modulation of appetite. The invention also relates to such use as well as to pharmaceutical formulations comprising a compound of formula (I).

  该发明涉及通式（I）的化合物，其中R0、R1、R2、R3、R4、R5、R6、R7、R8、R9、Ar和X如描述中所定义，或其药学上可接受的盐、水合物、几何异构体、消旋体、互变异构体、光学异构体、N-氧化物及其前药形式。这些化合物可用于治疗或预防与MCH1R受体相关的疾病，并用于调节食欲。该发明还涉及该用途以及包含通式（I）化合物的药物配方。
• Substituted acid derivatives useful as antidiabetic and antiobesity agents and method
  申请人：Cheng T. Peter

  公开号：US20070015797A1

  公开（公告）日：2007-01-18

  Compounds are provided which have the structure wherein Q is C or N, A is O or S, Z is O or a bond, X is CH or N and R 1 , R 2 , R 2a , R 2b , R 2c , R 3 , Y, x, m, and n are as defined herein, which compounds are useful as antidiabetic, hypolipidemic, and antiobesity agents.

  提供了一些化合物，它们的结构如下：其中Q为C或N，A为O或S，Z为O或键，X为CH或N，R1、R2、R2a、R2b、R2c、R3、Y、x、m和n如此定义，这些化合物可用作抗糖尿病、降脂和抗肥胖药物。
• US6124323
  申请人：——

  公开号：——

  公开（公告）日：——
• A Novel Diketopyrrolopyrrole (DPP)-Based [2]Rotaxane for Highly Selective Optical Sensing of Fluoride
  作者：Mandapati V. Ramakrishnam Raju、Hong-Cheu Lin

  DOI：10.1021/ol400221h

  日期：2013.3.15

  A novel [2]rotaxane based on an orthogonal H-bonded motif and 3,6-di(thiophen-2-yl)pyrrolo[3,4-c]pyrrole-1,4(2H,5H)-dione (DPP) with controlled topicity was successfully constructed, displaying excellent stimulated responses toward anion and solvent polarity. The preorganized host selectively recognized F- with high optical sensitivity and reversibility via enhanced positive cooperativity and noncovalent interaction by evidence of a shorter fluorescence lifetime.