1-methylindole-2-carboxaldehyde hydrazone | 16572-17-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 1-methylindole-2-carboxaldehyde hydrazone
• 英文别名: N-Methylindolyl-2-methylen-hydrazin；1-(N-Methylindolyl-2-methylen)-hydrazin；1-methyl-indole-2-carbaldehyde hydrazone；(1-Methylindol-2-yl)methylidenehydrazine
• CAS: 16572-17-1
• 化学式: C₁₀H₁₁N₃
• 分子量: 173.217
• InChiKey: QUEMXXSNJVRPNI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  43.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  1-甲基吲哚-2-甲醛 在 hydrazine hydrate 作用下， 以 甲醇 为溶剂， 反应 1.0h， 生成 1-methylindole-2-carboxaldehyde hydrazone
  参考文献：
  名称：

  通过活化 CF键，将多氟芳烃与nes类进行Umpolung交叉偶联†

  摘要：

  提出了一种将多氟芳烃与各种取代的azo酮交叉偶联以构建C（sp 2）–C（sp 3）键的umpolung策略。在这种策略下，多氟芳烃的C–F键在温和的条件下被裂解并与湿气和空气稳定的hydr偶联，并具有良好或优异的收率。该方法为合成多氟化药物和功能材料提供了有用的工具。

  DOI：

  10.1039/c9cc04299g

文献信息

• Antioxidant activity of indole-based melatonin analogues in erythrocytes and their voltammetric characterization
  作者：Sibel Suzen、Betul Tekiner-Gulbas、Hanif Shirinzadeh、Duysal Uslu、Hande Gurer-Orhan、Mehmet Gumustas、Sibel Aysil Ozkan

  DOI：10.3109/14756366.2012.717223

  日期：2013.12.1

  Melatonin (MLT) is a strong free-radical scavenger, which protects the body from the effects of oxidants. In recent years, MLT have been described resulting in much attention in the development of synthetic compounds possessing. As a part of our ongoing study a series of indole-based MLT analogue hydrazide/hydrazone derivatives were synthesized, characterized and in vitro antioxidant activity was investigated by evaluating their reducing effect against oxidation of a redox sensitive fluorescent probe. Membrane stabilizing effect of all compounds was also investigated by lactate dehydrogenase leakage assay. Furthermore voltammetric methods have been applied to the synthesized compounds to characterize oxidation potentials to get insight into their metabolism owing to the oxidation mechanisms taking place at the electrode and in the body share similar principles.