16-氯十六烷酸 | 2536-34-7

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 中文名称: 16-氯十六烷酸
• 英文名称: 16-chlorohexadecanoic acid
• CAS: 2536-34-7
• 化学式: C₁₆H₃₁ClO₂
• 分子量: 290.874
• InChiKey: GORBJGYRHORLLP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.1
• 重原子数：
  19
• 可旋转键数：
  15
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.94
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  methyl 16-hydroxy-(E)-9-hexadecenoate 在 palladium on activated charcoal 四氯化碳 、 sodium hydroxide 、 氢气 、 三苯基膦 作用下， 反应 12.0h， 生成 16-氯十六烷酸
  参考文献：
  名称：

  Subramanian; Passey, Sarita, Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1998, vol. 37, # 1, p. 23 - 27

  摘要：

  DOI：

文献信息

• Amphiphilic block copolymer and polymeric composition comprising the same for drug delivery
  申请人：Seo Hyo Min

  公开号：US20050201972A1

  公开（公告）日：2005-09-15

  The present invention relates to an amphiphilic block copolymer of a hydrophilic block and a hydrophobic block with a terminal hydroxyl group wherein the terminal hydroxyl group of the hydrophobic bock is substituted with a tocopherol or cholesterol group. It also relates to polymeric compositions capable of forming stable micelles in an aqueous solution, comprising the amphiphilic block copolymer and a polylactic acid derivative wherein one or more ends of the polylactic acid are covalently bound to at least one carboxyl group.

  本发明涉及一种两性块共聚物，包括亲水性块和疏水性块，其末端羟基团与生育酚或胆固醇基团取代的疏水性块。还涉及能在水溶液中形成稳定胶束的聚合物组合物，包括该两性块共聚物和聚乳酸衍生物，其中聚乳酸的一个或多个末端与至少一个羧基共价结合。
• A General Catalytic Method for Highly Cost‐ and Atom‐Efficient Nucleophilic Substitutions
  作者：Peter H. Huy、Isabel Filbrich

  DOI：10.1002/chem.201800588

  日期：2018.5.23

  A general formamide‐catalyzed protocol for the efficient transformation of alcohols into alkyl chlorides, which is promoted by substoichiometric amounts (down to 34 mol %) of inexpensive trichlorotriazine (TCT), is introduced. This is the first example of a TCT‐mediated dihydroxychlorination of an OH‐containing substrate (e.g., alcohols and carboxylic acids) in which all three chlorine atoms of TCT

  介绍了一种一般的甲酰胺催化方案，用于将醇有效转化为烷基氯，这是通过亚化学计量的量（低至34 mol％）的廉价三氯三嗪（TCT）促进的。这是TCT介导的含OH底物（例如，醇和羧酸）的二羟基氯化的第一个例子，其中TCT的所有三个氯原子都转移到了起始原料中。因此，增强的原子经济性可显着改善废物平衡（电子因子低至4），成本效率和可扩展性（> 50 g）。此外，当前的程序以高水平的官能团相容性和立体选择性为特色，因为仅释放弱酸性氰尿酸作为排他性副产物。最后，一锅法制备胺N 2反演，证明了所提出方法的高实用价值。
• Amphiphilic block copolymer and polymeric compostition comprising the same for drug delivery
  申请人：Seo Min Hyo

  公开号：US20080152616A1

  公开（公告）日：2008-06-26

  The present invention relates to an amphiphilic block copolymer of a hydrophilic block and a hydrophobic block with a terminal hydroxyl group wherein the terminal hydroxyl group of the hydrophobic bock is substituted with a tocopherol or cholesterol group. It also relates to polymeric compositions capable of forming stable micelles in an aqueous solution, comprising the amphiphilic block copolymer and a polylactic acid derivative wherein one or more ends of the polylactic acid are covalently bound to at least one carboxyl group.

  本发明涉及一种含有端羟基的两亲嵌段共聚物，其中包括亲水性块和疏水性块，疏水性块的端羟基被替换为生育酚或胆固醇基团。本发明还涉及一种聚合物组合物，能够在水溶液中形成稳定的微粒，包括上述两亲嵌段共聚物和聚乳酸衍生物，其中聚乳酸的一个或多个末端与至少一个羧基共价结合。
• Substituted 3,6 bis-(aminoalkoxy)acridines, and a process for their preparation
  申请人：AMERICAN CYANAMID COMPANY

  公开号：EP0031407A1

  公开（公告）日：1981-07-08

  Compounds selected from the group consisting of those of the formula: wherein n is the integer 1, 2 or 3; R1 and R2 are each hydrogen or methyl; R3 and R4 are the same or different and are hydrogen or straight chain or branched alkyl (C1-C4); and R3 and R4 taken together with the associated N(itro- gen) is pyrrolidino, piperidino, morpholino or N-methylpiperazino; and R5, R6 and R, may be the same or different and are selected from the group consisting of hydrogen, fluoro, chloro, bromo and nitro; with the proviso that when n is one or two and R, and R2 are hydrogen or methyl and R3 and R4 are lower alkyl then at least one of Rs, R6 and R7 must be a substituent other than hydrogen; the pharmacologically acceptable metal complexes thereof and the pharmacologically acceptable acid-addition salts thereof. A process for their preparation and compositions of matter useful for inducing the regression of tumors in warm-blooded animals and for enhancing the immune system, and the method of treatment of tumors and enhancing the immune response in mammals therewith, the active ingredients of said compositions of matter being certain 3,6-bis(aminoalkoxy)acridines or the pharmacologically acceptable acidaddition salts thereof.

  选自由下列式子组成的化合物组 其中 n 为整数 1、2 或 3；R1 和 R2 分别为氢或甲基；R3 和 R4 相同或不同，且为氢或直链或支链烷基（C1-C4）；R3 和 R4 与相关的 N(itro-gen)合在一起为吡咯烷基、哌啶基、吗啉基或 N-甲基哌嗪基；R5、R6 和 R 可以相同或不同，且选自由氢、氟、氯、溴和硝基组成的组；但条件是，当 n 为 1 或 2，R 和 R2 为氢或甲基，R3 和 R4 为低级烷基时，Rs、R6 和 R7 中至少有一个必须是氢以外的取代基；其药理上可接受的金属络合物及其药理上可接受的酸加成盐。 一种用于诱导温血动物肿瘤消退和增强免疫系统的制备工艺和物质组合物，以及用其治疗肿瘤和增强哺乳动物免疫反应的方法，所述物质组合物的活性成分是某些3,6-双(氨基烷氧基)吖啶或其药理学上可接受的酸加成盐。
• Polymeric michelle composition with improved stability
  申请人：——

  公开号：US20040253195A1

  公开（公告）日：2004-12-16

  Polymeric compositions capable of forming stable micelles in an aqueous solution, comprising an amphiphilic block copolymer of a hydrophilic block and a hydrophobic block, and a polylactic acid derivative wherein one end of the polylactic acid is covalently bound to at least one carboxyl group. The carboxyl group of the polylactic acid derivative may be fixed with a di- or tri-valent metal ion, obtained by adding the di- or tri-valent metal ion to the polymeric composition.

  能在水溶液中形成稳定胶束的聚合物组合物，包括亲水嵌段和疏水嵌段的两亲嵌段共聚物，以及聚乳酸衍生物，其中聚乳酸的一端与至少一个羧基共价结合。聚乳酸衍生物的羧基可以用二价或三价金属离子固定，方法是将二价或三价金属离子加入聚合物组合物中。