2,2-Dimethyl-propionic acid (4aS,6R,7R,8R,8aR)-7-acetoxy-4-azido-8-methoxy-hexahydro-pyrano[3,2-d][1,3]dioxin-6-ylmethyl ester | 195703-43-6

• 分子结构分类: 有机化合物 - 有机杂环化合物
• 英文名称: 2,2-Dimethyl-propionic acid (4aS,6R,7R,8R,8aR)-7-acetoxy-4-azido-8-methoxy-hexahydro-pyrano[3,2-d][1,3]dioxin-6-ylmethyl ester
• CAS: 195703-43-6
• 化学式: C₁₆H₂₅N₃O₈
• 分子量: 387.39
• InChiKey: DYYPGNJQLYHKMP-QYABOVLDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  27.0
• 可旋转键数：
  5.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  138.28
• 氢给体数：
  0.0
• 氢受体数：
  9.0

反应信息

• 作为反应物：
  描述：

  2,2-Dimethyl-propionic acid (4aS,6R,7R,8R,8aR)-7-acetoxy-4-azido-8-methoxy-hexahydro-pyrano[3,2-d][1,3]dioxin-6-ylmethyl ester 在 palladium on activated charcoal 氢气 作用下， 以 乙酸乙酯 为溶剂， 生成 2,2-Dimethyl-propionic acid (4aS,6R,7R,8R,8aR)-7-acetoxy-4-amino-8-methoxy-hexahydro-pyrano[3,2-d][1,3]dioxin-6-ylmethyl ester
  参考文献：
  名称：

  Synthesis and biological activity of artificial analogs of mycalamide A

  摘要：

  Artificial analogs of mycalamide A, a potent antitumor and antiviral compound isolated from a New Zealand marine sponge, were synthesized and their biological activities were tested. (C) 1997 Published by Elsevier Science Ltd.

  DOI：

  10.1016/s0960-894x(97)00365-x
• 作为产物：
  描述：

  1,2,4,6-tetra-O-acetate-2-O-methyl-α-D-glucopyranoside 在 吡啶 、 三氟甲磺酸三甲基硅酯 、 三氟化硼乙醚 、 potassium carbonate 作用下， 以 甲醇 、 二氯甲烷 、 乙腈 为溶剂， 生成 2,2-Dimethyl-propionic acid (4aS,6R,7R,8R,8aR)-7-acetoxy-4-azido-8-methoxy-hexahydro-pyrano[3,2-d][1,3]dioxin-6-ylmethyl ester
  参考文献：
  名称：

  Synthesis and biological activity of artificial analogs of mycalamide A

  摘要：

  Artificial analogs of mycalamide A, a potent antitumor and antiviral compound isolated from a New Zealand marine sponge, were synthesized and their biological activities were tested. (C) 1997 Published by Elsevier Science Ltd.

  DOI：

  10.1016/s0960-894x(97)00365-x