N-(2-methyl-1H-indol-5-yl)benzamide | 132515-37-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: N-(2-methyl-1H-indol-5-yl)benzamide
• 英文别名: N-(2-methyl-indol-5-yl)-benzamide；N-(2-Methyl-indol-5-yl)-benzamid
• CAS: 132515-37-8
• 化学式: C₁₆H₁₄N₂O
• 分子量: 250.3
• InChiKey: GXRAVFCYXQCDLO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  19
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  44.9
• 氢给体数：
  2
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  2-甲基-5-硝基吲哚 在 乙醇 、 镍 、 一水合肼 作用下， 反应 2.0h， 生成 N-(2-methyl-1H-indol-5-yl)benzamide
  参考文献：
  名称：

  Terent'ew et al., Zhurnal Obshchei Khimii, 1959, vol. 29, p. 2541,2550; engl. Ausg. S. 2504, 2511

  摘要：

  DOI：

文献信息

• Inhibition of monoamine oxidase by indole and benzofuran derivatives
  作者：Louis H.A. Prins、Jacobus P. Petzer、Sarel F. Malan

  DOI：10.1016/j.ejmech.2010.07.005

  日期：2010.10

  Monoamine oxidase (MAO) is an important drug target for the treatment of neurological disorders. A series of indole and benzofuran derivatives were synthesised and evaluated as inhibitors of the two MAO isoforms, MAO-A and MAO-B. In general, the derivatives were found to be selective MAO-B inhibitors with K(1) values in the nanoMolar (nM) to microMolar (mu M) concentration range. The most potent MAO-B inhibitor, 3,4-dichloro-N-(2-methyl-1H-indol-5-yl)benzamide, exhibited a K, value of 0 03 mu M and was 99 fold more selective for the B isoform. We conclude that these indole and benzofuran derivatives are promising reversible MAO-B inhibitors with a possible role in the treatment of neurodegenerative diseases such as Parkinson's disease (PD). (C) 2010 Elsevier Masson SAS. All rights reserved.
• Terent'ew et al., Zhurnal Obshchei Khimii, 1959, vol. 29, p. 2541,2550; engl. Ausg. S. 2504, 2511
  作者：Terent'ew et al.

  DOI：——

  日期：——