4-nitro-2-indanyl acetate | 51927-75-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 茚满类
• 英文名称: 4-nitro-2-indanyl acetate
• 英文别名: 2-acetoxy-4-nitroindan；4-nitro-2,3-dihydro-1H-inden-2-yl acetate；(4-nitro-2,3-dihydro-1H-inden-2-yl) acetate
• CAS: 51927-75-4
• 化学式: C₁₁H₁₁NO₄
• 分子量: 221.213
• InChiKey: UPTQNAIHYHAGDE-UHFFFAOYSA-N

物化性质

• 沸点：
  335.2±42.0 °C(Predicted)
• 密度：
  1.31±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  72.1
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  4-nitro-2-indanyl acetate 以 乙醇 为溶剂， 生成 4-amino-2,3-dihydro-1H-inden-2-yl acetate
  参考文献：
  名称：

  4-Heterocyclic-substituted-2-indanyl alcohols and insecticidal ester

  摘要：

  揭示了一种新颖的化合物，其化学式为##STR1##其中R.sup.1是从呋喃基、噻吩基、吡啶基、嘧啶基、噁唑基、吡咯基、异噁唑基、噻唑基和异噻唑基中选择的杂环基，R.sup.2是氢、四甲基环丙烷羰基、1-(取代苯基)-2-甲基丙基-1-羰基、1-(4-乙氧基苯基)-2,2-二氯环丙烷羰基或取代乙烯环丙烷羰基。其中R.sup.2不是氢的化合物是杀虫剂。

  公开号：

  US04442296A1
• 作为产物：
  描述：

  4-nitro-2,3-dihydro-1H-inden-2-ol 生成 4-nitro-2-indanyl acetate
  参考文献：
  名称：

  ENGEL, J. F.

  摘要：

  DOI：

文献信息

• [EN] TETRAHYDRO-NAPHTHALENE AND UREA DERIVATIVES<br/>[FR] DERIVES DE TETRAHYDRO-NAPHTHALENE ET D'UREE
  申请人：BAYER HEALTHCARE AG

  公开号：WO2005040100A1

  公开（公告）日：2005-05-06

  This invention relates to tetrahydro-naphthalene and urea derivatives and salts thereof which are useful as active ingredients of pharmaceutical preparations. The tetrahydro-naphthalene and urea derivatives of the present invention have vanilloid receptor (VR1) antagonistic activity, and can be used for the prophylaxis and treatment of diseases associated with VR1 activity, in particular for the treatment of urological diseases or disorders, such as detrusor overactivity (overactive bladder), urinary incontinence, neurogenic detrusor oeractivity (detrusor hyperflexia), idiopathic detrusor overactivity (detrusor instability), benign prostatic hyperplasia, and lower urinary tract symptoms; chronic pain, neuropathic pain, postoperative pain, rheumatoid arthritic pain, neuralgia, neuropathies, algesia, nerve injury, ischaemia, neurodegeneration, stroke, and inflammatory disorders such as asthma and chronic obstructive pulmonary (or airways) disease (COPD). BHC 03 2 001-Foreign-Countries - 66 - BHC 03 2 001-Foreign-Countries - 65 -

  这项发明涉及四氢萘和脲衍生物及其盐，这些物质可作为药物制剂的活性成分。本发明的四氢萘和脲衍生物具有辣椒素受体（VR1）拮抗活性，可用于预防和治疗与VR1活性相关的疾病，特别是用于治疗与VR1活性相关的泌尿系统疾病或紊乱，如膀胱过度活动（过度活跃膀胱）、尿失禁、神经源性膀胱过度活动（膀胱过度反射）、特发性膀胱过度活动（膀胱不稳定）、良性前列腺增生、下尿路症状；慢性疼痛、神经病性疼痛、术后疼痛、类风湿性关节炎疼痛、神经痛、神经病、疼痛、神经损伤、缺血、神经退行性疾病、中风，以及哮喘和慢性阻塞性肺病（COPD）等炎症性疾病。BHC 03 2 001-外国国家 - 66 - BHC 03 2 001-外国国家 - 65 -
• [EN] TETRAHYDRO-NAPHTHALENE AND UREA DERIVATIVES<br/>[FR] TETRAHYDRO-NAPHTALENE ET DERIVES D'UREE
  申请人：BAYER HEALTHCARE AG

  公开号：WO2005040119A1

  公开（公告）日：2005-05-06

  This invention relates to a hydroxy-tetrahydro-naphthalene or an urea derivative formula (I) and salts thereof which are useful as active ingredients of pharmaceutical preparations, wherein A represents formula (II) or (III) wherein # represents the connection position to the molecule and Q1a, Q2a, Q3a and Q4a are defined, and E represents formula (IV) or (V) wherein # represents the connection position to the molecule and Q1b, Q2b, Q3b, Q4b, Q5b, R1b, na, ma, Xa and Ra are defined.

  这项发明涉及一种羟基四氢萘或脲衍生物公式(I)及其盐，它们作为药物制剂的活性成分，其中A代表公式(II)或(III)，其中#代表分子的连接位置，Q1a、Q2a、Q3a和Q4a被定义，E代表公式(IV)或(V)，其中#代表分子的连接位置，Q1b、Q2b、Q3b、Q4b、Q5b、R1b、na、ma、Xa和Ra被定义。
• Novel 2,3-disubstituted primary para-phenylenediamines and process for oxidation dyeing of keratin fibers
  申请人：Ramos-Stanbury Laure

  公开号：US20070011823A1

  公开（公告）日：2007-01-18

  Disclosed herein are para-phenylenediamine compounds of formula (I), and their salts and solvates: wherein R 1 and R 2 form, together with the carbon atoms to which they are attached, a 4-, 5-, 6- or 7-membered ring, wherein the ring comprises carbon atoms and, optionally, one or two atoms chosen from oxygen and nitrogen, the ring being optionally substituted, with the proviso that when the ring comprises two atoms chosen from oxygen and nitrogen, these two atoms are non-adjacent. Compositions comprising these compounds and processes of making them, as well as processes and kits for dyeing keratin fibers are also disclosed.

  本文披露了化学式(I)的对苯二胺化合物及其盐和溶剂合物：其中R1和R2与它们附着的碳原子一起形成4、5、6或7成员环，该环包括碳原子，可选择地包括一个或两个来自氧和氮的原子，该环可选择地被取代，但当环包括两个来自氧和氮的原子时，这两个原子不相邻。还披露了包含这些化合物的组合物、制备它们的方法，以及用于染色角蛋白纤维的方法和工具箱。
• Tetradydro-Naphthalene And Urea Derivatives
  申请人：Bouchon Axel

  公开号：US20080045546A1

  公开（公告）日：2008-02-21

  This invention relates to tetrahydro-naphthalene and urea derivatives and salts thereof which are useful as active ingredients of pharmaceutical preparations. The tetrahydro-naphthalene and urea derivatives of the present invention have vanilloid receptor (VR1) antagonistic activity, and can be used for the prophylaxis and treatment of diseases associated with VR1 activity, in particular for the treatment of urological diseases or disorders, such as detrusor overactivity (overactive bladder), urinary incontinence, neurogenic detrusor overactivity (detrusor hyperflexia), idiopathic detrusor overactivity (detrusor instability), benign prostatic hyperplasia, and lower urinary tract symptoms; chronic pain, neuropathic pain, postoperative pain, rheumatoid arthritic pain, neuralgia, neuropathies, algesia, nerve injury, ischaemia, neurodegeneration, stroke, and inflammatory disorders such as asthma and chronic obstructive pulmonary (or airways) disease (COPD).

  本发明涉及四氢萘和脲衍生物及其盐，其作为制药制剂的活性成分具有vanilloid受体（VR1）拮抗活性，可用于预防和治疗与VR1活性相关的疾病，特别是用于治疗泌尿系统疾病或障碍，如膀胱过度活动（过度活动膀胱），尿失禁，神经源性膀胱过度活动（膀胱过度反射），特发性膀胱过度活动（膀胱不稳定），良性前列腺增生和下尿路症状；慢性疼痛，神经病性疼痛，术后疼痛，类风湿性关节炎疼痛，神经痛，神经病，疼痛，神经损伤，缺血，神经退行性疾病，中风以及哮喘和慢性阻塞性肺（或气道）疾病（COPD）等炎症性疾病。
• Tetrahydro-naphthalene and urea derivatives
  申请人：Bouchon Axel

  公开号：US20070167458A1

  公开（公告）日：2007-07-19

  This invention relates to a hydroxy-tetrahydro-naphthalene or an urea derivative formula (I) and salts thereof which are useful as active ingredients of pharmaceutical preparations, wherein A represents formula (II) or (III) wherein # represents the connection position to the molecule and Q 1a , Q 2a , Q 3a and Q 4a are defined, and E represents formula (IV) or (V) wherein # represents the connection position to the molecule and Q 1b , Q 2b , Q 3b , Q 4b , Q 5b , R 1b , na, ma, X a and R a are defined.

  本发明涉及一种羟基四氢萘或脲衍生物公式(I)及其盐，其可用作制药制剂的活性成分，其中A代表公式(II)或(III)，其中#代表连接到分子的位置，Q1a、Q2a、Q3a和Q4a被定义；E代表公式(IV)或(V)，其中#代表连接到分子的位置，Q1b、Q2b、Q3b、Q4b、Q5b、R1b、na、ma、Xa和Ra被定义。