2-acetylcyclohexanol | 63718-26-3

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-acetylcyclohexanol
• 英文别名: 1-(2-hydroxycyclohexyl)ethanone
• CAS: 63718-26-3
• 化学式: C₈H₁₄O₂
• 分子量: 142.198
• InChiKey: GPYOABAXMVHVBU-UHFFFAOYSA-N

物化性质

• 沸点：
  242.3±33.0 °C(Predicted)
• 密度：
  1.055±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  10
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  1-(7-氧杂双环[4.1.0]庚-1-基)乙酮 在 sodium hydrogen telluride 作用下， 以 乙醇 为溶剂， 以89%的产率得到2-acetylcyclohexanol
  参考文献：
  名称：

  CHEMO- AND REGIOSELECTIVE REDUCTION OF α,β-EPOXY KETONES TO β-HYDROXY KETONES BY SODIUM HYDROGENTELLURIDE

  摘要：

  α,β-环氧酮通过氢化钠选择性地还原为β-羟基酮，产率良好。

  DOI：

  10.1246/cl.1984.271

文献信息

• Hepatitis C Virus Inhibitors
  申请人：Bristol-Myers Squibb Company

  公开号：US20150023913A1

  公开（公告）日：2015-01-22

  The present disclosure is generally directed to antiviral compounds, and more specifically directed to combinations of compounds which can inhibit the function of the NS5A protein encoded by Hepatitis C virus (HCV), compositions comprising such combinations, and methods for inhibiting the function of the NS5A protein.

  本公开涉及抗病毒化合物，更具体地涉及能够抑制由丙型肝炎病毒（HCV）编码的NS5A蛋白功能的化合物组合，包括这种组合的组成物，以及抑制NS5A蛋白功能的方法。
• CHEMO- AND REGIOSELECTIVE REDUCTION OF α,β-EPOXY KETONES TO β-HYDROXY KETONES BY SODIUM HYDROGENTELLURIDE
  作者：Atsuhiro Osuka、Koji Taka-Oka、Hitomi Suzuki

  DOI：10.1246/cl.1984.271

  日期：1984.2.5

  α,β-Epoxy ketones were chemo- and regioselectively reduced to β-hydroxy ketones by sodium hydrogenteiiuride in good yields.

  α,β-环氧酮通过氢化钠选择性地还原为β-羟基酮，产率良好。
• METHOD FOR PRODUCING CYCLOHEXYL ALKYL KETONES
  申请人：Nishiuchi Junya

  公开号：US20120178970A1

  公开（公告）日：2012-07-12

  Provided is an industrially superior method for producing cyclohexyl alkyl ketones, which solves the problems in process reduction and in disposal of wastes such as metals. An aromatic ketone represented by a formula (1) is nuclear-hydrogenated with pressurized hydrogen and in the presence of a solvent at a temperature of from 20 to 120° C., in the presence of a catalyst that carries from 0.1 to 20% by weight of a ruthenium atom on the carrier, thereby producing a cyclohexyl alkyl ketone represented by a formula (2): provided that, in the formula (2), n indicates an integer of from 1 to 3; R represents a hydroxyl group, a cyclohexyl group, an alkyl group having from 1 to 4 carbon atoms, or an acyl group having from 1 to 4 carbon atoms

  提供了一种在工业上优越的生产环己基烷基酮的方法，解决了在过程减少和处理废物（如金属）方面的问题。通过在20至120°C的温度下，在有溶剂存在的情况下使用加压氢气进行核氢化，存在携带从0.1到20%重量的钌原子的催化剂，从而产生一个由式（2）表示的环己基烷基酮：其中，在式（2）中，n表示1到3之间的整数；R代表一个羟基、一个环己基、一个含有1至4个碳原子的烷基或一个含有1至4个碳原子的酰基。
• Combinations of Hepatitis C Virus Inhibitors
  申请人：BRISTOL-MYERS SQUIBB COMPANY

  公开号：US20160158200A1

  公开（公告）日：2016-06-09

  The present disclosure is generally directed to antiviral compounds, and more specifically directed to combinations of compounds which can inhibit the function of the NS5A protein encoded by Hepatitis C virus (HCV), compositions comprising such combinations, and methods for inhibiting the function of the NS5A protein.

  本公开涉及抗病毒化合物，更具体地涉及能够抑制丙型肝炎病毒（HCV）编码的NS5A蛋白功能的化合物组合，包含这种组合的组合物，以及抑制NS5A蛋白功能的方法。
• FOULING RELEASE COATING COMPOSITION
  申请人：Jotun A/S

  公开号：EP3974481A1

  公开（公告）日：2022-03-30

  A fouling release coating composition free of tin compounds comprising: (a) a polysiloxane-based binder system comprising at least one curable polysiloxane-based binder A having a weight average Mw of 50,000 g/mol or less, such as 8,000 to 50,000 g/mol and wherein binder A constitutes at least 27 wt.% of the total polysiloxane-based binder system; (b) at least one low molecular weight amidine or low molecular weight amine compound.

  一种不含锡化合物的去污涂层组合物，包括 (a) 一种聚硅氧烷基粘结剂体系，包括至少一种可固化的聚硅氧烷基粘结剂 A，其重量平均 Mw 为 50,000 g/mol 或以下，例如 8,000 至 50,000 g/mol，其中粘结剂 A 至少占聚硅氧烷基粘结剂体系总量的 27 wt.%； (b) 至少一种低分子量胺或低分子量胺化合物。