(3R)-4-[(4-methoxyphenyl)methoxy]butane-1,3-diol

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (3R)-4-[(4-methoxyphenyl)methoxy]butane-1,3-diol
• 英文别名: (R)-4-(4-Methoxy-benzyloxy)-butane-1,3-diol
• 化学式: C₁₂H₁₈O₄
• 分子量: 226.273
• InChiKey: GCVOAHFIFQYCKH-LLVKDONJSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  16
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  58.9
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  (3R)-4-[(4-methoxyphenyl)methoxy]butane-1,3-diol 在 吡啶 、 三乙胺 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 生成
  参考文献：
  名称：

  A novel enantioselective synthesis of (+)-myriocin based on the chemistry of 1-trimethylsilylbuta-2,3-dienes

  摘要：

  A synthesis of (+)-myriocin has been achieved in a highly stereoselective manner employing TiCl4 catalyzed addition of 1-trimethylsilylbuta-2,3-diene to an aldehyde and Et2AlCl catalysed cyclization of an epoxytrichloroacetimidate for the construction of its alpha-substituted serine structure having three contiguous asymmetric centers. (C) 1997 Elsevier Science Ltd.

  DOI：

  10.1016/s0040-4039(97)10077-6
• 作为产物：
  描述：

  (E)-4-((4-methoxybenzyl)oxy)but-2-en-1-ol 在 titanium(IV) isopropylate 、 叔丁基过氧化氢 、 L-(+)-酒石酸二异丙酯 、 红铝 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 生成 (3R)-4-[(4-methoxyphenyl)methoxy]butane-1,3-diol
  参考文献：
  名称：

  A novel enantioselective synthesis of (+)-myriocin based on the chemistry of 1-trimethylsilylbuta-2,3-dienes

  摘要：

  A synthesis of (+)-myriocin has been achieved in a highly stereoselective manner employing TiCl4 catalyzed addition of 1-trimethylsilylbuta-2,3-diene to an aldehyde and Et2AlCl catalysed cyclization of an epoxytrichloroacetimidate for the construction of its alpha-substituted serine structure having three contiguous asymmetric centers. (C) 1997 Elsevier Science Ltd.

  DOI：

  10.1016/s0040-4039(97)10077-6

文献信息

• A novel enantioselective synthesis of (+)-myriocin based on the chemistry of 1-trimethylsilylbuta-2,3-dienes
  作者：Susumi Hatakeyama、Masashi Yoshida、Tomoyuki Esumi、Yoshiharu Iwabuchi、Hiroshi Irle、Toshiki Kawamoto、Hidetoshi Yamada、Mugio Nishizawa

  DOI：10.1016/s0040-4039(97)10077-6

  日期：1997.11

  A synthesis of (+)-myriocin has been achieved in a highly stereoselective manner employing TiCl4 catalyzed addition of 1-trimethylsilylbuta-2,3-diene to an aldehyde and Et2AlCl catalysed cyclization of an epoxytrichloroacetimidate for the construction of its alpha-substituted serine structure having three contiguous asymmetric centers. (C) 1997 Elsevier Science Ltd.