cyano-di(3-phenyl-prop-1-yl)acetic acid methyl ester | 1202778-95-7

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二芳基庚烷
• 英文名称: cyano-di(3-phenyl-prop-1-yl)acetic acid methyl ester
• 英文别名: Methyl 2-cyano-5-phenyl-2-(3-phenylpropyl)pentanoate
• CAS: 1202778-95-7
• 化学式: C₂₂H₂₅NO₂
• 分子量: 335.446
• InChiKey: JLGVTYBQSRFBLB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.6
• 重原子数：
  25
• 可旋转键数：
  10
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  50.1
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  cyano-di(3-phenyl-prop-1-yl)acetic acid methyl ester 在 水 、 氢气 、 溶剂黄146 、 三乙胺 、 lithium hydroxide 作用下， 以 1,4-二氧六环 、 甲醇 、 水 为溶剂， 20.0~100.0 ℃ 、100.0 kPa 条件下， 反应 156.0h， 生成 2-(((tert-Butoxycarbonyl)amino)methyl)-5-phenyl-2-(3-phenylpropyl)pentanoic acid
  参考文献：
  名称：

  Synthesis of Cationic Antimicrobial β^2,2-Amino Acid Derivatives with Potential for Oral Administration

  摘要：

  We have prepared a series of highly potent achiral cationic beta(2,2)-amino acid derivatives that fulfill the Lipinski's rule of five and that contain the basic structural requirements of short cationic antimicrobial peptides. Highest antimicrobial potency was observed for one of the smallest beta(2,2)-amino acid derivatives (M-w 423.6) exhibiting a MIC of 3.8 mu M against methicillin-resistant Staphylococcus aureus (MRSA), methicillin-resistant Staphylococcus epidermidis (MRSE), and Staphylococcus aureus, and 7.7 mu M against Escherichia coli. The beta(2,2)-amino acid derivatives were shown to have similar absorption properties as several commercially available drugs, and the results implied a resembling membrane disrupting mechanism of action as reported for much larger cationic antimicrobial peptides. By their high potency, nontoxicity, absorption properties, and ease of synthesis, the beta(2,2)-amino acid derivatives demonstrate a way to modify a vastly investigated class of cationic antimicrobial peptides into small drug-like molecules with high commercial potential.

  DOI：

  10.1021/jm101327d
• 作为产物：
  描述：

  1-溴-3-苯基丙烷 在 sodium methylate 作用下， 以 甲醇 为溶剂， 反应 0.66h， 生成 cyano-di(3-phenyl-prop-1-yl)acetic acid methyl ester
  参考文献：
  名称：

  Synthesis of Cationic Antimicrobial β^2,2-Amino Acid Derivatives with Potential for Oral Administration

  摘要：

  We have prepared a series of highly potent achiral cationic beta(2,2)-amino acid derivatives that fulfill the Lipinski's rule of five and that contain the basic structural requirements of short cationic antimicrobial peptides. Highest antimicrobial potency was observed for one of the smallest beta(2,2)-amino acid derivatives (M-w 423.6) exhibiting a MIC of 3.8 mu M against methicillin-resistant Staphylococcus aureus (MRSA), methicillin-resistant Staphylococcus epidermidis (MRSE), and Staphylococcus aureus, and 7.7 mu M against Escherichia coli. The beta(2,2)-amino acid derivatives were shown to have similar absorption properties as several commercially available drugs, and the results implied a resembling membrane disrupting mechanism of action as reported for much larger cationic antimicrobial peptides. By their high potency, nontoxicity, absorption properties, and ease of synthesis, the beta(2,2)-amino acid derivatives demonstrate a way to modify a vastly investigated class of cationic antimicrobial peptides into small drug-like molecules with high commercial potential.

  DOI：

  10.1021/jm101327d

文献信息

• Synthesis of anticancer heptapeptides containing a unique lipophilic β2,2-amino acid building block
  作者：Veronika Tørfoss、Dominik Ausbacher、Cristiane de A. Cavalcanti-Jacobsen、Terkel Hansen、Bjørn-Olav Brandsdal、Martina Havelkova、Morten B. Strøm

  DOI：10.1002/psc.1434

  日期：2012.3

  We report a series of synthetic anticancer heptapeptides (H‐KKWβ2,2WKK‐NH2) containing eight different central lipophilic β2,2‐amino acid building blocks, which have demonstrated high efficiency when used as scaffolds in small cationic antimicrobial peptides and peptidomimetics. The most potent peptides in the present study had IC50 values of 9–23 µm against human Burkitt's lymphoma and murine B‐cell

  我们报告了一系列合成的抗癌七肽的（H-KKW β 2,2- WKK-NH 2）包含八个不同的中心的亲脂性β 2,2- α-氨基酸结构单元，作为支架以小的阳离子抗微生物肽一起使用时，其已经证明高效率和拟肽。在本研究中最有效的肽具有IC 50个的9-23μ值米针对人伯基特氏淋巴瘤和鼠B细胞淋巴瘤和均nonhaemolytic（EC 50  > 200μ米）。最有前途的肽10e还显示出对人胚胎肺成纤维细胞和外周血单核细胞的低毒性以及出色的蛋白水解稳定性。版权所有©2012欧洲肽协会和John Wiley＆Sons，Ltd.
• Antimicrobial Activity of Small β-Peptidomimetics Based on the Pharmacophore Model of Short Cationic Antimicrobial Peptides
  作者：Terkel Hansen、Tore Alst、Martina Havelkova、Morten B. Strøm

  DOI：10.1021/jm901052r

  日期：2010.1.28

  We have synthesized a series of small beta-peptidomimetics (M-w < 650) that were based on the minimal pharmacophore model for anti-Staphylococcal activity of short cationic antimicrobial peptides. All beta-peptidomimetics had a net charge of +2 and formed an amphipathic scaffold consisting of an achiral lipophilic beta(2,2)-amino acid coupled to a C-terminal L-arginine amide residue. By varying the lipophilic side-chains of the beta(2,2)-amino acids, we obtained a series of highly potent beta-peptidomimetics with high enzymatic stability against alpha-chymotrypsin and a general low toxicity against human erythrocytes. The most potent beta-peptidomimetics displayed minimal inhibitory concentrations of 2.1-7.2 mu M against Staphylococcus aureus, methicillin resistant Staphylococcus aureus (MRSA), methicillin resistant Staphylococcus epidermidis (MRSE), and Escherichia coli, Small amphipathic beta-peptidomimetics may be a promising class of antimicrobial agents by means of having a similar range of potency and selectivity as larger cationic antimicrobial peptides in addition to improved enzymatic stability and lower costs of production.
• Synthesis of Cationic Antimicrobial β^2,2-Amino Acid Derivatives with Potential for Oral Administration
  作者：Terkel Hansen、Dominik Ausbacher、Gøril E. Flaten、Martina Havelkova、Morten B. Strøm

  DOI：10.1021/jm101327d

  日期：2011.2.10

  We have prepared a series of highly potent achiral cationic beta(2,2)-amino acid derivatives that fulfill the Lipinski's rule of five and that contain the basic structural requirements of short cationic antimicrobial peptides. Highest antimicrobial potency was observed for one of the smallest beta(2,2)-amino acid derivatives (M-w 423.6) exhibiting a MIC of 3.8 mu M against methicillin-resistant Staphylococcus aureus (MRSA), methicillin-resistant Staphylococcus epidermidis (MRSE), and Staphylococcus aureus, and 7.7 mu M against Escherichia coli. The beta(2,2)-amino acid derivatives were shown to have similar absorption properties as several commercially available drugs, and the results implied a resembling membrane disrupting mechanism of action as reported for much larger cationic antimicrobial peptides. By their high potency, nontoxicity, absorption properties, and ease of synthesis, the beta(2,2)-amino acid derivatives demonstrate a way to modify a vastly investigated class of cationic antimicrobial peptides into small drug-like molecules with high commercial potential.