AcO(CH2)6ZnBr | 1092560-29-6

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: AcO(CH2)6ZnBr
• CAS: 1092560-29-6
• 化学式: C₈H₁₅BrO₂Zn
• 分子量: 288.5
• InChiKey: DGTJMYLYLYZOHE-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  2.92
• 重原子数：
  12.0
• 可旋转键数：
  7.0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  26.3
• 氢给体数：
  0.0
• 氢受体数：
  2.0

反应信息

• 作为反应物：
  描述：

  AcO(CH2)6ZnBr 在 N-溴代丁二酰亚胺(NBS) 、 1,2-双(二苯基膦)乙烷氯化镍 、 lithium bromide 作用下， 以 四氢呋喃 、 N,N-二甲基甲酰胺 为溶剂， 生成 6-(2,5-dibromothiophene-3-yl)hexyl acetate
  参考文献：
  名称：

  Facile synthesis of 3-(ω-acetoxyalkyl)thiophenes and derived copolythiophenes using Rieke zinc

  摘要：

  An optimized synthetic protocol toward highly reactive Rieke zinc is applied for the preparation of a series of omega-(2,5-dibromothiophene-3-yl)alkyl acetate monomers and statistical copolythiophenes derived thereof, with 10% of ester-functionalized side chains. The obtained conjugated polymers are attractive electron donor materials for organic solar cells, notably to increase the thermodynamic stability of the bulk heterojunction polymer:fullerene active layer blend, and are fully characterized by a combination of spectroscopic, thermal analysis and electrochemical techniques. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.reactfunctpolym.2013.11.009
• 作为产物：
  描述：

  二烷基二硫代磷酸锌 在 锌 作用下， 以 四氢呋喃 为溶剂， 反应 3.0h， 生成 AcO(CH2)6ZnBr
  参考文献：
  名称：

  Facile synthesis of 3-(ω-acetoxyalkyl)thiophenes and derived copolythiophenes using Rieke zinc

  摘要：

  An optimized synthetic protocol toward highly reactive Rieke zinc is applied for the preparation of a series of omega-(2,5-dibromothiophene-3-yl)alkyl acetate monomers and statistical copolythiophenes derived thereof, with 10% of ester-functionalized side chains. The obtained conjugated polymers are attractive electron donor materials for organic solar cells, notably to increase the thermodynamic stability of the bulk heterojunction polymer:fullerene active layer blend, and are fully characterized by a combination of spectroscopic, thermal analysis and electrochemical techniques. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.reactfunctpolym.2013.11.009

文献信息

• Method for the synthesis of phospholipid ethers
  申请人：Pinchuk Anatoly

  公开号：US20080312459A1

  公开（公告）日：2008-12-18

  Disclosed are improved methods for the synthesis of phospholipid ether analogs and alkyl phosphocholine analogs. The methods allow greater versatility of the reactants used and greater ease in synthesizing alkyl chains of varying length while affording reaction temperatures at room temperature or below. The methods disclosed herein provide reactants and conditions using alkyl halides and organozinc reagents and do not utilize Gringard reactions thus, allowing greater ease of their separation and purity of products. The PLE compounds synthesized by the methods disclosed herein can also be used for synthesizing high specific activity phospholipid ether (PLE) analogs, for use in treatment and diagnosis of cancer.

  揭示了改进的合成磷脂醚类似物和烷基磷胆碱类似物的方法。这些方法允许使用更多种反应物，并更容易合成不同长度的烷基链，同时在室温或更低温度下进行反应。本文所披露的方法提供了使用烷基卤化物和有机锌试剂的反应物和条件，不使用格林纳德反应，从而使它们更容易分离并提高产品的纯度。通过本文披露的方法合成的PLE化合物也可用于合成高特异活性的磷脂醚（PLE）类似物，用于癌症的治疗和诊断。
• METHOD FOR PRODUCING POLYESTER
  申请人：Nippon Soda Co., Ltd.

  公开号：EP3248998A1

  公开（公告）日：2017-11-29

  A cyclic ester such as lactides and the like is mixed, in an organic solvent, with an alkyl aluminum compound such as trimethyl aluminum, triethyl aluminum and the like, and then, to the resulting mixture, at least one selected from the group consisting of an organic lithium ring-opening polymerization catalyst, an organic sodium ring-opening polymerization catalyst, an organic potassium ring-opening polymerization catalyst, an organic zinc ring-opening polymerization catalyst, an organic magnesium ring-opening polymerization catalyst, an organic tin ring-opening polymerization catalyst, an organic calcium ring-opening polymerization catalyst, an organic titanium ring-opening polymerization catalyst, and an amine ring-opening polymerization catalyst to allow ring-opening polymerization of the cyclic ester, thereby a polyester is obtained.

  在有机溶剂中，将环状酯（如乳酰胺等）与烷基铝化合物（如三甲基铝、三乙基铝等）混合，然后在所得混合物中加入至少一种选自以下组别的催化剂：有机锂开环聚合催化剂、有机钠开环聚合催化剂、有机钾开环聚合催化剂、有机锌开环聚合催化剂、有机镁开环聚合催化剂、有机锡开环聚合催化剂、有机钙开环聚合催化剂、有机镁开环聚合催化剂、有机锡开环聚合催化剂、有机钙开环聚合催化剂、有机锌开环聚合催化剂、有机镁开环聚合催化剂、有机锡开环聚合催化剂、有机钙开环聚合催化剂、有机钛开环聚合催化剂和胺开环聚合催化剂中的至少一种，使环酯开环聚合，从而得到聚酯。
• Method for producing polyester
  申请人：NIPPON SODA CO., LTD.

  公开号：US10577460B2

  公开（公告）日：2020-03-03

  A cyclic ester, for example 3,6-bis[2-(methylthio)ethyl]-1,4-dioxane-2,5-dione, is mixed, in an organic solvent, with an alkyl aluminum compound represented by a formula [I]: Rn Al X3-n, for example trimethyl aluminum, triethyl aluminum, tri-isobutyl aluminum, tri-n-hexyl aluminum, tri-n-butyl aluminum, tri-n-octyl aluminum, diethyl aluminum chloride, ethyl aluminum sesquichloride, ethyl aluminum dichloride, or diisobutyl aluminum hydride. The resulting mixture is then mixed with at least one ring-opening polymerization catalyst selected from the group consisting of a dialkyl zinc and a dialkyl magnesium to allow ring-opening polymerization of the cyclic ester, thereby obtaining a polyester.

  在有机溶剂中，将环酯，例如 3,6-双[2-(甲硫基)乙基]-1,4-二氧六环-2,5-二酮，与由式 [I] 表示的烷基铝化合物混合：Rn Al X3-n，例如三甲基铝、三乙基铝、三异丁基铝、三正己基铝、三正丁基铝、三正辛基铝、二乙基氯化铝、乙基倍半氯化铝、乙基二氯化铝或二异丁基氢化铝。然后将所得混合物与至少一种开环聚合催化剂混合，该催化剂选自二烷基锌和二烷基镁组成的组，使环酯开环聚合，从而得到聚酯。