2,2′-[(2-methylenepropane-1,3-diyl)bis(oxy)]dibenzaldehyde | 324541-88-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 2,2′-[(2-methylenepropane-1,3-diyl)bis(oxy)]dibenzaldehyde
• 英文别名: Benzaldehyde, 2,2'-[(2-methylene-1,3-propanediyl)bis(oxy)]bis-；2-[2-[(2-formylphenoxy)methyl]prop-2-enoxy]benzaldehyde
• CAS: 324541-88-0
• 化学式: C₁₈H₁₆O₄
• 分子量: 296.323
• InChiKey: DOCIVMINUZOPFD-UHFFFAOYSA-N

物化性质

• 沸点：
  486.4±35.0 °C(Predicted)
• 密度：
  1.187±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  22
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  52.6
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2,2′-[(2-methylenepropane-1,3-diyl)bis(oxy)]dibenzaldehyde 反应 10.0h， 以79%的产率得到Benzaldehyde, 3,3'-(2-methylene-1,3-propanediyl)bis[2-hydroxy-
  参考文献：
  名称：

  Highly selective formation of 2∶2 macrocycles from a novel hydroxybenzaldehyde derivative and diamines

  摘要：

  具有异丁烯基连接的羟基苯甲醛衍生物与多种二胺发生反应，可有效生成 2â¶2大环化合物。

  DOI：

  10.1039/b005536k
• 作为产物：
  描述：

  3-氯-2-氯甲基丙烯 、 邻甲基苄醇 在 sodium hydride 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 12.0h， 以70%的产率得到2,2′-[(2-methylenepropane-1,3-diyl)bis(oxy)]dibenzaldehyde
  参考文献：
  名称：

  Novel synthesis of macrocycles with chalcone moieties through mixed aldol reaction

  摘要：

  24-Membered novel macrocycles with chalcone structural moieties and isobutenyl ether linkages in the core have been prepared through mixed aldol reaction. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(01)01793-2

文献信息

• A cascade process for the synthesis of <i>ortho</i>-formyl allyl aryl ethers and 2<i>H</i>-chromen-2-ol derivatives from arynes <i>via</i> trapping of <i>o</i>-quinone methide with an activated alkene
  作者：Abhilash Sharma、Pranjal Gogoi

  DOI：10.1039/c8ob02507j

  日期：——

  A transition-metal free synthetic strategy has been developed for the direct synthesis of ortho-formyl substituted allyl aryl ethers via a cascade three-component coupling of arynes, activated alkene and N,N-dimethylformamide. The reaction proceeds via C–O and C–C bond cleavage as well as C–C and two new C–O bond formations in a single reaction vessel. The methodology provides a good yield of ortho-formyl

  已经开发了无过渡金属的合成策略，用于通过芳烃，活化的烯烃和N，N-二甲基甲酰胺的级联三组分偶联直接合成邻甲酰基取代的烯丙基芳基醚。反应通过C–O和C–C键断裂以及C–C和两个新的C–O键形成在一个反应​​容器中进行。该方法提供了邻甲酰基取代的烯丙基芳基醚的良好产率。而且，该合成策略已经用于2 H-铬烯-2-醇衍生物的一锅法合成。
• [EN] METHODS, COMPOSITIONS, AND APPARATUSES FOR FORMING MACROCYCLIC COMPOUNDS<br/>[FR] PROCEDES, COMPOSITIONS ET APPAREILS PERMETTANT DE FORMER DES COMPOSES MACROCYCLIQUES
  申请人：JOHNSON THOMAS E

  公开号：WO2006025859A3

  公开（公告）日：2006-11-23
• METHODS, COMPOSITIONS, AND APPARATUSES FOR FORMING MACROCYCLIC COMPOUNDS
  申请人：Johnson, Thomas E.

  公开号：EP1716153B1

  公开（公告）日：2013-10-09
• Methods, compositions, and apparatuses for forming macrocyclic compounds
  申请人：Johnson E. Thomas

  公开号：US20070217965A1

  公开（公告）日：2007-09-20

  This invention relates to methods, compositions, and apparatuses for producing macrocyclic compounds. First, one or more reactants are provided in a reaction medium, which are capable of forming the macrocyclic compound through a desired reaction pathway that includes at least cyclization, and which are further capable of forming undesired oligomers through a undesired reaction pathway that includes undesirable oligomerization. Oligomerization of such reactions in the reaction medium is modulated to reduce formation of undesired oligomers and/or to reduce separation of the undesired oligomers from the reaction medium, relative to a corresponding unmodulated oligomerization reaction, thereby maximizing yields of the macrocyclic compound. The macrocyclic compound so formed is then recovered from the reaction medium. Preferably, the macrocyclic compound spontaneously separates from the reaction medium via phase separation. More preferably, the macrocyclic compound spontaneous precipitates from the reaction medium and therefore can be easily recovered by simple filtration.
• US7709632B2
  申请人：——

  公开号：US7709632B2

  公开（公告）日：2010-05-04