Boc-L-ornithine N-carboxyanhydride | 96165-58-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Boc-L-ornithine N-carboxyanhydride
• 英文别名: tert-Butyl (S)-(3-(2,5-dioxooxazolidin-4-yl)propyl)carbamate；tert-butyl N-[3-[(4S)-2,5-dioxo-1,3-oxazolidin-4-yl]propyl]carbamate
• CAS: 96165-58-1
• 化学式: C₁₁H₁₈N₂O₅
• 分子量: 258.274
• InChiKey: NJUWWDKWBAQLNA-ZETCQYMHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  18
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.73
• 拓扑面积：
  93.7
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  (2S)-2,5-双[(叔丁氧羰基)氨基]戊酸 在 三乙胺 、 N,N-二甲基甲酰胺 作用下， 以 二氯甲烷 、 乙酸乙酯 为溶剂， 反应 0.5h， 生成 Boc-L-ornithine N-carboxyanhydride
  参考文献：
  名称：

  A new approach to the preparation of N-carboxy .alpha.-amino acid anhydrides

  摘要：

  DOI：

  10.1021/jo00212a042

文献信息

• [EN] POLY(ORNITHINE) HOMOPOLYMERS FOR THE DELIVERY OF OLIGONUCLEOTIDES<br/>[FR] HOMOPOLYMÈRES DE POLY(ORNITHINE) POUR L'ADMINISTRATION D'OLIGONUCLÉOTIDES
  申请人：MERCK SHARP & DOHME

  公开号：WO2013016057A1

  公开（公告）日：2013-01-31

  The present invention provides poly(amide) polymers, polyconjugates, compositions and methods for the delivery of oligonucleotides for therapeutic purposes.

  本发明提供了用于治疗目的的寡核苷酸递送的聚酰胺聚合物，聚共轭物，组合物和方法。
• POLY(AMIDE) POLYMERS FOR THE DELIVERY OF OLIGONUCLEOTIDES
  申请人：Barrett Stephanie E.

  公开号：US20130253135A1

  公开（公告）日：2013-09-26

  The present invention provides poly(amide) polymers, polyconjugates, compositions and methods for the delivery of oligonucleotides for therapeutic purposes.

  本发明提供了用于治疗目的的寡核苷酸传递的聚酰胺聚合物，聚共轭物，组成物和方法。
• An in vivo evaluation of amphiphilic, biodegradable peptide copolymers as siRNA delivery agents
  作者：Stephanie E. Barrett、Marc T. Abrams、Rob Burke、Brian A. Carr、Louis S. Crocker、Robert M. Garbaccio、Bonnie J. Howell、Eric A. Kemp、Robert A. Kowtoniuk、Andrew H. Latham、Karen R. Leander、Anthony M. Leone、Mihir Patel、Sergey Pechenov、Nicole T. Pudvah、Sean Riley、Laura Sepp-Lorenzino、Eileen S. Walsh、J. Michael Williams、Steven L. Colletti

  DOI：10.1016/j.ijpharm.2014.03.011

  日期：2014.5

  A series of amphiphilic, biodegradable polypeptide copolymers were prepared for the delivery of siRNA (short interfering ribonucleic acid). The molecular weight (or polymer chain length) of the linear polymer was controlled by reaction stoichiometry for the 11.5, 17.2, and 24.6 kDa polypeptides, and the highest molecular weight polypeptide was prepared using a sequential addition method to obtain a polypeptide having a molecular weight of 38.6 kDa. These polymers were used to prepare polymer conjugate systems designed to target and deliver an apolipoprotein B (ApoB) siRNA to hepatocyte cells and to help delineate the effect of polymer molecular weight or polymer chain length on siRNA delivery in vivo. A clear trend in increasing potency was found with increasing molecular weight of the polymers examined (at a constant polymer: siRNA (w/w) ratio), with minimal toxicity found. Furthermore, the biodegradability of these polymer conjugates was examined and demonstrates the potential of these systems as siRNA delivery vectors. (C) 2014 Elsevier B. V. All rights reserved.
• US8987377B2
  申请人：——

  公开号：US8987377B2

  公开（公告）日：2015-03-24
• [EN] POLY(AMIDE) POLYMERS FOR THE DELIVERY OF OLIGONUCLEOTIDES<br/>[FR] POLYMÈRES POLY(AMIDE) DESTINÉS À L'ADMINISTRATION D'OLIGONUCLÉOTIDES
  申请人：MERCK SHARP & DOHME

  公开号：WO2012068187A1

  公开（公告）日：2012-05-24

  The present invention provides poly(amide) polymers, polyconjugates, compositions and methods for the delivery of oligonucleotides for therapeutic purposes.