N-[(3-methoxyphenyl)methyl]-N,2-dimethylprop-2-enamide | 1144029-11-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: N-[(3-methoxyphenyl)methyl]-N,2-dimethylprop-2-enamide
• CAS: 1144029-11-7
• 化学式: C₁₃H₁₇NO₂
• 分子量: 219.283
• InChiKey: ANINHTWKGSXHEE-UHFFFAOYSA-N

物化性质

• 沸点：
  383.3±25.0 °C(predicted)
• 密度：
  1.036±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  16
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  29.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  N-[(3-methoxyphenyl)methyl]-N,2-dimethylprop-2-enamide 在 过氧化双月桂酰 、 一水合肼 作用下， 以 甲醇 为溶剂， 反应 48.0h， 生成 1,3-dimethyl-3-(2-aminoethyl)-5-methoxyoxindole
  参考文献：
  名称：

  A metal-free synthesis of oxindoles by a radical addition-cyclization onto N-arylacrylamides with xanthates

  摘要：

  A convenient, high yielding synthesis of oxindoles by metal-free di-functionalization of alkenes with xanthates has been developed. This transformation involves a radical addition/cyclization process. Various arylalkylation products including alkyl ester-, benzyl-, cyano-, ketone-, amine-, and amide-substituted oxindoles were prepared in good to excellent yields. (C) 2015 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2015.01.049
• 作为产物：
  描述：

  N-甲基-3-甲氧基苄胺 、 甲基丙烯酰氯 在 4-二甲氨基吡啶 、 三乙胺 作用下， 以 二氯甲烷 为溶剂， 以49%的产率得到N-[(3-methoxyphenyl)methyl]-N,2-dimethylprop-2-enamide
  参考文献：
  名称：

  Mechanistic study of 7-endo selective radical cyclization of the aryl radical

  摘要：

  Mechanistic studies on the novel 7-endo selective radical cyclization were carried out. The reaction afforded three products, 7-endo product, 6-exo product, and reduced product. The distribution of these products was estimated by GC analyses. The 7-endo/6-exo selectivity was almost constant against variation in the concentration of Bu3SnH, while the reduction/cyclization ratio was sensitive to the concentration of Bu3SnH. The reduction/cyclization ratio was mainly affected by the rotational isomeric ratio of the cyclization precursor. Kinetic analyses indicated that the cyclization process should be irreversible, and the rate constant of 7-endo/6-exo radical cyclization was estimated to be about 3.3 x 10(8) s (1) at 80 degrees C. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2009.01.132

文献信息

• A metal-free synthesis of oxindoles by a radical addition-cyclization onto N-arylacrylamides with xanthates
  作者：Shucheng Wang、Xuhu Huang、Bowen Li、Zemei Ge、Xin Wang、Runtao Li

  DOI：10.1016/j.tet.2015.01.049

  日期：2015.3

  A convenient, high yielding synthesis of oxindoles by metal-free di-functionalization of alkenes with xanthates has been developed. This transformation involves a radical addition/cyclization process. Various arylalkylation products including alkyl ester-, benzyl-, cyano-, ketone-, amine-, and amide-substituted oxindoles were prepared in good to excellent yields. (C) 2015 Elsevier Ltd. All rights reserved.
• Mechanistic study of 7-endo selective radical cyclization of the aryl radical
  作者：Akio Kamimura、Yuriko Ishihara、Masahiro So、Takahiro Hayashi

  DOI：10.1016/j.tetlet.2009.01.132

  日期：2009.4

  Mechanistic studies on the novel 7-endo selective radical cyclization were carried out. The reaction afforded three products, 7-endo product, 6-exo product, and reduced product. The distribution of these products was estimated by GC analyses. The 7-endo/6-exo selectivity was almost constant against variation in the concentration of Bu3SnH, while the reduction/cyclization ratio was sensitive to the concentration of Bu3SnH. The reduction/cyclization ratio was mainly affected by the rotational isomeric ratio of the cyclization precursor. Kinetic analyses indicated that the cyclization process should be irreversible, and the rate constant of 7-endo/6-exo radical cyclization was estimated to be about 3.3 x 10(8) s (1) at 80 degrees C. (C) 2009 Elsevier Ltd. All rights reserved.