3,6,9,12-Tetraoxadocosane, 1-bromo- | 183785-29-7

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 3,6,9,12-Tetraoxadocosane, 1-bromo-
• 英文别名: 1-[2-[2-[2-(2-bromoethoxy)ethoxy]ethoxy]ethoxy]decane
• CAS: 183785-29-7
• 化学式: C₁₈H₃₇BrO₄
• 分子量: 397.393
• InChiKey: GRXPOPSTJHPHGS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  23
• 可旋转键数：
  20
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  36.9
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  四聚乙二醇单癸醚 在 吡啶 、 二溴亚砜 作用下， 以 苯 为溶剂， 反应 24.0h， 以76%的产率得到3,6,9,12-Tetraoxadocosane, 1-bromo-
  参考文献：
  名称：

  A DNA−Lipid Complex in Organic Media and Formation of an Aligned Cast Film¹

  摘要：

  A novel DNA-lipid complex,is prepared by replacing sodium counter cations by cationic amphiphilic lipids (1). The DNA-lipid complex is insoluble in aqueous solutions, but is soluble in most organic media such as benzene, ethanol, and chloroform. The DNA-lipid complex was confirmed to form double helical strands even in organic media, and the internal conformation of DNA strands could be reversibly changed from B-form to C-form in the organic solution (CHCl3/EtOH = 4:1) by changing the water content. A self-standing, water-insoluble DNA-lipid (1) film was prepared by casting from the organic solution and could be stretched to produce oriented DNA strands with their axes aligned along the stretching direction. The film can be impregnated with the drug ethidium. bromide in the aqueous solution. The linear dichroism characteristics of the drug-DNA film show that the DNA strands are well oriented and the ethidium molecules are intercalated, as they are in normal aqueous solutions.

  DOI：

  10.1021/ja9617855

文献信息

• A DNA−Lipid Complex in Organic Media and Formation of an Aligned Cast Film¹
  作者：Kentaro Tanaka、Yoshio Okahata

  DOI：10.1021/ja9617855

  日期：1996.1.1

  A novel DNA-lipid complex,is prepared by replacing sodium counter cations by cationic amphiphilic lipids (1). The DNA-lipid complex is insoluble in aqueous solutions, but is soluble in most organic media such as benzene, ethanol, and chloroform. The DNA-lipid complex was confirmed to form double helical strands even in organic media, and the internal conformation of DNA strands could be reversibly changed from B-form to C-form in the organic solution (CHCl3/EtOH = 4:1) by changing the water content. A self-standing, water-insoluble DNA-lipid (1) film was prepared by casting from the organic solution and could be stretched to produce oriented DNA strands with their axes aligned along the stretching direction. The film can be impregnated with the drug ethidium. bromide in the aqueous solution. The linear dichroism characteristics of the drug-DNA film show that the DNA strands are well oriented and the ethidium molecules are intercalated, as they are in normal aqueous solutions.