tert-butyl (2,6-dichlorophenoxy)dimethylsilane | 188645-80-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: tert-butyl (2,6-dichlorophenoxy)dimethylsilane
• 英文别名: tert-butyl(2,6-dichlorophenoxy)dimethylsilane；tert-butyl-(2,6-dichlorophenoxy)-dimethylsilane
• CAS: 188645-80-9
• 化学式: C₁₂H₁₈Cl₂OSi
• 分子量: 277.266
• InChiKey: UEXSXJDSPVVSCK-UHFFFAOYSA-N

物化性质

• 沸点：
  294.7±20.0 °C(Predicted)
• 密度：
  1.084±0.06 g/cm3(Predicted)
• 保留指数：
  1634.9;1606.4

计算性质

• 辛醇/水分配系数(LogP)：
  5.38
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  tert-butyl (2,6-dichlorophenoxy)dimethylsilane 在 lithium acetate 作用下， 以 水 、 N,N-二甲基甲酰胺 为溶剂， 反应 3.0h， 以94%的产率得到2,6-二氯苯酚
  参考文献：
  名称：

  LiOAc-Catalyzed Chemoselective Deprotection of Aryl Silyl Ethers under Mild Conditions

  摘要：

  An efficient and chemoselective deprotection protocol for aryl silyl ethers using LiOAc as a bifunctional Lewis acid-Lewis base catalyst was described. Acetates, epoxides, and aliphatic silyl ethers were preserved, whereas aryl TBS and TBDPS ethers can be differentiated.

  DOI：

  10.1021/jo802472s
• 作为产物：
  描述：

  2,6-二氯苯酚 、 叔丁基二甲基氯硅烷 在 咪唑 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 以98%的产率得到tert-butyl (2,6-dichlorophenoxy)dimethylsilane
  参考文献：
  名称：

  Compounds, Compositions and Methods Comprising Pyridazine Derivatives

  摘要：

  本发明涉及化合物、组合物和方法，用于治疗动物中对抑制功能性囊性纤维化跨膜传导调节因子（CFTR）多肽敏感的疾病，通过向需要的哺乳动物中给予本文中定义的化合物的有效量（包括表1或2中列出的化合物或由公式I、Ia、II、III和IV包含的化合物）或包含这些化合物的组合物，从而治疗该疾病。本发明特别涉及一种治疗腹泻和多囊肾病的方法。

  公开号：

  US20100267706A1

文献信息

• Compounds, Compositions and Methods Comprising Heteroaromatic Derivatives
  申请人：Doyle Kevin James

  公开号：US20090318429A1

  公开（公告）日：2009-12-24

  The present invention relates to compositions and methods for treating a disease in an animal, which disease is responsive to inhibiting of functional cystic fibrosis transmembrane conductance regulator (CFTR) polypeptide by administering to a mammal in need thereof an effective amount of a compound defined herein (including those compounds set forth in Tables 1-14 or encompassed by formulas I-XII) or compositions thereof, thereby treating the disease. The present invention particularly, relates to a method of treating diarrhea and polycystic kidney disease.

  本发明涉及用于治疗动物中对抑制功能性囊性纤维化跨膜传导调节因子（CFTR）多肽敏感的疾病的组合物和方法，通过向需要的哺乳动物投予本文所定义的化合物的有效量（包括表1-14中列出的化合物或公式I-XII所涵盖的化合物）或其组合物，从而治疗该疾病。本发明特别涉及一种治疗腹泻和多囊肾病的方法。
• Compounds, compositions and methods comprising heteroaromatic derivatives
  申请人：Doyle Kevin James

  公开号：US20100144733A1

  公开（公告）日：2010-06-10

  The present invention relates to compositions and methods for treating a disease in an animal, which disease is responsive to inhibiting of functional cystic fibrosis transmembrane conductance regulator (CFTR) polypeptide by administering to a mammal in need thereof an effective amount of a compound defined herein (including those compounds set forth in Tables 1-14 or encompassed by formulas I-XII) or compositions thereof, thereby treating the disease. The present invention particularly, relates to a method of treating diarrhea and polycystic kidney disease.

  本发明涉及用于治疗动物体内对抑制功能性囊性纤维化跨膜传导调节因子（CFTR）多肽敏感的疾病的组合物和方法，通过向需要治疗该疾病的哺乳动物中投与本文所定义的化合物的有效量（包括表1-14中列出的化合物或公式I-XII所包含的化合物）或其组合物，从而治疗该疾病。本发明特别涉及治疗腹泻和多囊肾病的方法。
• LiOAc-Catalyzed Chemoselective Deprotection of Aryl Silyl Ethers under Mild Conditions
  作者：Bing Wang、Hui-Xia Sun、Zhi-Hua Sun

  DOI：10.1021/jo802472s

  日期：2009.2.20

  An efficient and chemoselective deprotection protocol for aryl silyl ethers using LiOAc as a bifunctional Lewis acid-Lewis base catalyst was described. Acetates, epoxides, and aliphatic silyl ethers were preserved, whereas aryl TBS and TBDPS ethers can be differentiated.
• Compounds, Compositions and Methods Comprising Pyridazine Derivatives
  申请人：Russell Michael Geoffrey Neil

  公开号：US20090270398A1

  公开（公告）日：2009-10-29

  The present invention relates to compositions and methods for treating a disease in an animal, which disease is responsive to inhibiting of functional cystic fibrosis transmembrane conductance regulator (CFTR) polypeptide by administering to a mammal in need thereof an effective amount of a compound defined herein (including those compounds set forth in Table 1 or encompassed by formula I) or compositions thereof, thereby treating the disease. The present invention particularly, relates to a method of treating diarrhea and polycystic kidney disease.

  本发明涉及用于治疗动物患病的组合物和方法，该疾病对通过向需要的哺乳动物投予本文中定义的有效量的化合物（包括表1中列出的那些化合物或由公式I包含的化合物）或其组合物来抑制功能性囊性纤维化跨膜传导调节蛋白（CFTR）多肽产生响应，从而治疗该疾病。本发明特别涉及治疗腹泻和多囊肾病的方法。