2-carbethoxy-1,3-butadiene | 44804-88-8

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 2-carbethoxy-1,3-butadiene
• 英文别名: Ethyl 1,3-butadien-2-carboxylat；2-Methylene-3-butenoic acid ethyl ester；ethyl 2-methylidenebut-3-enoate
• CAS: 44804-88-8
• 化学式: C₇H₁₀O₂
• 分子量: 126.155
• InChiKey: VCIGZCZEWQKTQR-UHFFFAOYSA-N

物化性质

• 沸点：
  153.6±9.0 °C(Predicted)
• 密度：
  0.917±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  9
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-carbethoxy-1,3-butadiene 在 甲醇 、 sodium tetrahydroborate 、 sodium amalgam 、 lithium aluminium tetrahydride 、 三氟化硼乙醚 、 sodium hydride 、 magnesium sulfate 作用下， 以 四氢呋喃 、 甲醇 、 二氯甲烷 为溶剂， 反应 11.75h， 生成 吲哚并[2,3-a]喹嗪,3-乙基-1,2,3,4,6,7,12,12b-八氢-,反-
  参考文献：
  名称：

  An easy ABD→ABCD strategy to indolo[2,3-a]quinolizin-4-one. Synthesis of deplancheine and yohimbane

  摘要：

  The efficient synthesis of indolo[2,3-alpha]quinolizin-4-ones 2 is described in two steps via formal [3 + 3] cycloaddition reaction of alpha-sulfonyl tryptaminylacetamide 4 with various alpha, beta-unsaturated esters 5 and the regioselective reduction of the resulting glutarimides 3 with sodium borohydride then sequent further dehydrated cyclization in the presence of boron trifluoride etherate. The useful building block is applied to synthesize deplancheine (1a) and yohimbane (1b). (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2004.11.005
• 作为产物：
  描述：

  聚合甲醛 、 3-丁烯酸乙酯 在 sodium hydride 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 以91%的产率得到2-carbethoxy-1,3-butadiene
  参考文献：
  名称：

  Part II. Development of novel colchicine-derived immunosuppressants with improved pharmacokinetic properties

  摘要：

  We have developed a new series of immunosuppressant with improved pharmacokinetic properties as the second-generation of colchicine analogs, which were designed based on the privileged structure derived from our previous work. In particular, we identified an analog (14), which exhibited a potent in vitro activity (IC50: 5 nM) in MLR and excellent in vivo efficacy in the Zymosan A-induced arthritis model, in the Carrageenan-induced edema model and in the local lymph node assay (LLNA). Analog 14 also revealed a good oral bioavailability (F: 67.3%) in BALB/c mice. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2012.08.068

文献信息

• New composition for dynamicofunctional impressions
  申请人：Pasini, Giovanni

  公开号：EP0367058A2

  公开（公告）日：1990-05-09

  New composition, with controlled and programmed hardening, to record mucodynamic dental impressions, and comprising by percent weight: - Polyvinyl acetate (PVAc) 50-85% by weight - Low aliphatic ketones and aliphatic esters 0-25% by weight - Low alcohols and/or ethers 0-25% by weight - Non-toxic, non-aromatic, high-boiling plasticising oils in common use for PvAc 0-10% by weight - Non-toxic organic pigments, capable of imitating the colouring of the oral mucosa 0-2 % by weight

  用于记录粘液动力牙印的新型组合物，具有可控的程序化硬化，按重量百分比计： - 聚醋酸乙烯酯 (PVAc) 重量百分比为 50-85 - 低脂酮和脂酯 0-25% （重量百分比 - 低级醇和/或醚 0-25% （重量百分比 - 常用于 PvAc 的无毒、非芳烃、高沸点增塑油 0-10%（重量百分比 - 无毒有机颜料，能够模仿口腔粘膜的颜色 0-2 %（重量百分比
• Oxygen reduction disposable kits, devices and methods of use thereof
  申请人：New Health Sciences, Inc.

  公开号：US10058091B2

  公开（公告）日：2018-08-28

  The present disclosure relates to Oxygen Reduction Disposable kits (ORDKit), devices and methods for the improved preservation of whole blood and blood components. The improved devices and methods for the collection of blood and blood components provide for whole blood and blood components having reduced levels of oxygen. The devices and methods provide for the rapid preparation of deoxygenated blood and blood components for storage that improves the overall quality of the transfused blood and improves health outcomes in patients.

  本公开涉及用于改进全血和血液成分保存的减氧一次性套件（ORDKit）、装置和方法。这些用于采集血液和血液成分的改进装置和方法可提供氧气含量降低的全血和血液成分。这些设备和方法可快速制备脱氧血液和血液成分以供储存，从而提高输血的整体质量，改善患者的健康状况。
• Copolymer composition for semiconductive cable layer
  申请人：Steffl Thomas

  公开号：US10308794B2

  公开（公告）日：2019-06-04

  Described herein are polymer compositions useful as a semiconductive layer suitable for cables. The polymer compositions include (a) a heterophasic copolymer of propylene, (b) a polar copolymer having a polar comonomer having polar groups, (c) a solid conductive filler, and optionally (d) a polyolefin functionalised with a mono- or polycarboxylic acid compound or a derivative of a mono- or polycarboxylic acid compound, wherein said compostion is not crosslinked by the addition of a crosslinking agent. Also described herein is a process for producing the polymer compositions as well as the use of the compositions thereof.

  本文所述的聚合物组合物可用作适用于电缆的半导体层。这些聚合物组合物包括：(a) 丙烯的杂相共聚物；(b) 具有极性共聚单体的极性共聚物；(c) 固体导电填料；以及(d) 用单羧酸或多羧酸化合物或单羧酸或多羧酸化合物的衍生物官能化的聚烯烃，其中所述共聚物不通过添加交联剂进行交联。本文还描述了生产聚合物组合物的工艺及其组合物的用途。
• Process of tooth whitening and apparatus therefor
  申请人：Wasylucha Bryan

  公开号：US10285790B2

  公开（公告）日：2019-05-14

  A process of whitening a tooth provided by the invention includes the steps of providing a delivery device for mechanical dispensing of a predetermined amount of a whitening composition to an applicator tip; dispensing the amount of whitening composition to the applicator tip; applying the amount of whitening composition disposed on the applicator tip to the tooth to be whitened; and allowing the whitening composition to remain in contact with the tooth for a period of time sufficient to whiten the tooth. Optionally, the process further includes the step of exposing the whitening composition to light. A gum or candy for tooth bleaching is detailed along with methods of use. A device adapted to dispense an amount of a dental whitening composition optionally includes a light source for activating the whitener.

  本发明提供的一种牙齿美白工艺包括以下步骤：提供一种用于将预定量的美白组合物以机械方式分配到涂抹器尖端的输送装置；将一定量的美白组合物分配到涂抹器尖端；将涂抹器尖端上一定量的美白组合物涂抹到待美白的牙齿上；以及使美白组合物与牙齿保持接触一段时间，足以美白牙齿。可选地，该过程还包括将美白组合物暴露在光线下的步骤。详细介绍了一种用于漂白牙齿的口香糖或糖果及其使用方法。适于分配一定量牙齿美白组合物的装置可选地包括用于激活美白剂的光源。
• Oxygen reduction disposable kits, devices and methods of use thereof (ORDKit)
  申请人：Hemanext Inc.

  公开号：US11350626B2

  公开（公告）日：2022-06-07

  The present disclosure relates to Oxygen Reduction Disposable kits (ORDKit), devices and methods for the improved preservation of whole blood and blood components. The improved devices and methods for the collection of blood and blood components provide for whole blood and blood components having reduced levels of oxygen. The devices and methods provide for the rapid preparation of deoxygenated blood and blood components for storage that improves the overall quality of the transfused blood and improves health outcomes in patients.

  本公开涉及用于改进全血和血液成分保存的减氧一次性套件（ORDKit）、装置和方法。这些用于采集血液和血液成分的改进装置和方法可提供氧气含量降低的全血和血液成分。这些设备和方法可快速制备脱氧血液和血液成分以供储存，从而提高输血的整体质量，改善患者的健康状况。