3-(Decylsulfanyl)-N-[1,3-dihydroxy-2-(hydroxymethyl)propan-2-YL]propanamide | 134226-03-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 3-(Decylsulfanyl)-N-[1,3-dihydroxy-2-(hydroxymethyl)propan-2-YL]propanamide
• 英文别名: 3-decylsulfanyl-N-[1,3-dihydroxy-2-(hydroxymethyl)propan-2-yl]propanamide
• CAS: 134226-03-2
• 化学式: C₁₇H₃₅NO₄S
• 分子量: 349.535
• InChiKey: SDXDPETZUPEPKJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  23
• 可旋转键数：
  16
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.94
• 拓扑面积：
  115
• 氢给体数：
  4
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  3-(Decylsulfanyl)-N-[1,3-dihydroxy-2-(hydroxymethyl)propan-2-YL]propanamide 在 双氧水 作用下， 以 甲醇 为溶剂， 生成 Tris hydroxymethyl-(3-decylsulfinylpropanamido)-methane
  参考文献：
  名称：

  A new class of sulfoxide surfactants derived from Tris. Synthesis and preliminary assessments of their properties

  摘要：

  A new class of non-ionic amphiphilic molecules suitable for biological purposes, especially extraction of membrane proteins, is reported. Such surfactants were prepared in two steps : addition of alkyl or fluoroalkyl mercaptan on Tris(hydroxymethyl)acrylamidomethane (THAM) derivatives, followed by the oxydation of sulfide group in sulfoxide moiety in order to provide water solubility to the molecule. The detergent efficiency of these new surfactants were assayed on rat liver cells. (C) 1998 Elsevier Science Ltd. All nights reserved.

  DOI：

  10.1016/s0960-894x(98)00263-7
• 作为产物：
  描述：

  1-癸硫醇 、 N-三羟甲基甲基丙烯酰胺 在 偶氮二异丁腈 作用下， 以 甲醇 为溶剂， 以45%的产率得到3-(Decylsulfanyl)-N-[1,3-dihydroxy-2-(hydroxymethyl)propan-2-YL]propanamide
  参考文献：
  名称：

  新型非离子表面活性剂三（羟甲基）-丙烯酰胺基甲烷的端粒：合成及性能评估。

  摘要：

  据报道，适用于生物学目的的一类新的两亲分子，特别是膜蛋白和/或糖蛋白的提取。这些化合物是通过在烷基硫醇作为转移剂和α，α'-（偶氮二）-异丁腈（AIBN）作为引发剂的情况下，对Tris-（羟甲基）-丙烯酰胺基甲烷单体单元进行端粒化制备的。这些化合物显示出比市售表面活性剂相似或更好的去污剂性能。

  DOI：

  10.1016/0040-4039(91)80351-6

文献信息

• New surface active compounds, method for their preparation, and their use
  申请人：MONSANTO EUROPE S.A./N.V.

  公开号：EP0900786A1

  公开（公告）日：1999-03-10

  Compound according to formula    wherein    R is a linear or branched alkyl radical, optionally substituted having from 2 to 40 C-atoms; R1, R2, and R3 are the same or different and selected from lower alkyl; and R4, R5, and R6 are the same or different and selected from hydrogen, halogen or an alkali metal or alkali earth metal. The compound shows interesting surface active properties and a low toxicity profile, and is suitable for cosmetic, detergent and agricultural compositions.

  根据以下公式制备化合物：其中R是线性或支链烷基基团，可选地取代，含有2至40个碳原子；R1、R2和R3相同或不同，选自较低的烷基；R4、R5和R6相同或不同，选自氢、卤素或碱金属或碱土金属。该化合物具有有趣的表面活性性质和低毒性，适用于化妆品、洗涤剂和农业配方。
• A new class of sulfoxide surfactants derived from Tris. Synthesis and preliminary assessments of their properties
  作者：Philippe Barthélémy、Jean Claude Maurizis、Jean Michel Lacombe、Bernard Pucci

  DOI：10.1016/s0960-894x(98)00263-7

  日期：1998.6

  A new class of non-ionic amphiphilic molecules suitable for biological purposes, especially extraction of membrane proteins, is reported. Such surfactants were prepared in two steps : addition of alkyl or fluoroalkyl mercaptan on Tris(hydroxymethyl)acrylamidomethane (THAM) derivatives, followed by the oxydation of sulfide group in sulfoxide moiety in order to provide water solubility to the molecule. The detergent efficiency of these new surfactants were assayed on rat liver cells. (C) 1998 Elsevier Science Ltd. All nights reserved.
• Telomers of tris(hydroxymethyl)-acrylamidomethane, a new class of non-ionic surfactants: Synthesis and assessment of their properties.
  作者：Bernard Pucci、Andre A. Pavia

  DOI：10.1016/0040-4039(91)80351-6

  日期：1991.3

  A new class of amphiphilic molecules suitable for biological purposes, especially extraction of membrane proteins and/or glycoproteins, is reported. These compounds were prepared by telomerization of a Tris-(Hydroxymethyl)-acrylamidomethane monomeric unit in the presence of an alkyl thiol as transfer reagent and of α,α′-(azobis)-isobutyronitrile (AIBN) as initiator. These compounds show similar or

  据报道，适用于生物学目的的一类新的两亲分子，特别是膜蛋白和/或糖蛋白的提取。这些化合物是通过在烷基硫醇作为转移剂和α，α'-（偶氮二）-异丁腈（AIBN）作为引发剂的情况下，对Tris-（羟甲基）-丙烯酰胺基甲烷单体单元进行端粒化制备的。这些化合物显示出比市售表面活性剂相似或更好的去污剂性能。