6,6''-(((2,2-dimethylpropane-1,3-diyl)bis(oxy))bis(methylene))di-2,2'-bipyridine | 1352034-65-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 6,6''-(((2,2-dimethylpropane-1,3-diyl)bis(oxy))bis(methylene))di-2,2'-bipyridine
• 英文别名: 2-[[2,2-Dimethyl-3-[(6-pyridin-2-ylpyridin-2-yl)methoxy]propoxy]methyl]-6-pyridin-2-ylpyridine；2-[[2,2-dimethyl-3-[(6-pyridin-2-ylpyridin-2-yl)methoxy]propoxy]methyl]-6-pyridin-2-ylpyridine
• CAS: 1352034-65-1
• 化学式: C₂₇H₂₈N₄O₂
• 分子量: 440.545
• InChiKey: RBVFGAVXPDTVMM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  33
• 可旋转键数：
  10
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  70
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  6-甲基-2,2′-二吡啶 在 六氯乙烷 、 sodium hydride 、 cesium fluoride 、 sodium iodide 、 lithium diisopropyl amide 作用下， 以 四氢呋喃 、 正己烷 、 N,N-二甲基甲酰胺 、 乙腈 为溶剂， 反应 6.0h， 生成 6,6''-(((2,2-dimethylpropane-1,3-diyl)bis(oxy))bis(methylene))di-2,2'-bipyridine
  参考文献：
  名称：

  Air-Stable Heterobimetallic Catalysts to Effect Ni/Cr-Mediated Couplings with a ca. 1:1 Molar Ratio of Coupling Partners at Low Catalyst Loadings

  摘要：

  Two air-stable NI,Cr-heterobimetallic catalysts have been prepared from ligands 7 and 11, obtained from scyllo-inositol in four and three steps, respectively. Both catalysts smoothly promote Ni/Cr-mediated coupling reactions with a ca. 1:1 molar ratio of coupling partners. The catalyst derived from 11 exhibits a better catalytic profile, thereby allowing Ni/Cr-mediated coupling reactions to be achieved with a wide range of substrates at a low catalyst loading in an operationally simple manner.

  DOI：

  10.1021/ol202878v

文献信息

• Air-Stable Heterobimetallic Catalysts to Effect Ni/Cr-Mediated Couplings with a ca. 1:1 Molar Ratio of Coupling Partners at Low Catalyst Loadings
  作者：Jianbiao Peng、Yoshito Kishi

  DOI：10.1021/ol202878v

  日期：2012.1.6

  Two air-stable NI,Cr-heterobimetallic catalysts have been prepared from ligands 7 and 11, obtained from scyllo-inositol in four and three steps, respectively. Both catalysts smoothly promote Ni/Cr-mediated coupling reactions with a ca. 1:1 molar ratio of coupling partners. The catalyst derived from 11 exhibits a better catalytic profile, thereby allowing Ni/Cr-mediated coupling reactions to be achieved with a wide range of substrates at a low catalyst loading in an operationally simple manner.