ethyl 1-ethylindoline-2-carboxylate | 108797-61-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: ethyl 1-ethylindoline-2-carboxylate
• 英文别名: Ethyl 1-ethyl-2,3-dihydroindole-2-carboxylate
• CAS: 108797-61-1
• 化学式: C₁₃H₁₇NO₂
• 分子量: 219.283
• InChiKey: VRAXBEXCXQWTLT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  16
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  29.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  ethyl 1-ethylindoline-2-carboxylate 在 lithium aluminium tetrahydride 、 sodium chloride 作用下， 以 四氢呋喃 、 乙醚 、 水 为溶剂， 反应 0.67h， 以90 mg的产率得到(1-ethyl-2,3-dihydro-1H-indol-2-yl)methanol
  参考文献：
  名称：

  Discovery of selective indole-based prostaglandin D2 receptor antagonist

  摘要：

  A series of N-benzoyl-2-methylindole-3-acetic acids were synthesized and biologically evaluated as prostaglandin (PG) D-2 receptor antagonists. Some of the selected compounds significantly inhibited OVA-induced vascular permeability in guinea pig conjunctiva after oral dosing. Structure-activity relationship study is presented. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2011.06.014
• 作为产物：
  描述：

  吲哚-2-羧酸乙酯 在 三乙基硅烷 、 sodium hydride 作用下， 以 三氟乙酸 为溶剂， 反应 3.33h， 生成 ethyl 1-ethylindoline-2-carboxylate
  参考文献：
  名称：

  .alpha.2-Adrenergic agonists/antagonists: the synthesis and structure-activity relationships of a series of indolin-2-yl and tetrahydroquinolin-2-yl imidazolines

  摘要：

  The synthesis and alpha 2-adrenergic activity of a series of indolin-2-yl and tetrahydroquinolin-2-yl imidazolines are described. The indolin-2-yl imidazoline 4b was found to possess potent alpha 2-adrenergic agonist and antagonist activity. The modification of the substituents on the indoline ring of 4b has led to the separation of these activities. Substitution on the aromatic ring of 4b with halogen or increasing the size of the N-alkyl substituent of 4b gave alpha 2-adrenergic antagonists without agonist activity. The N-allylindoline 4d is more potent than idazoxan in vitro and is equipotent in vivo, but is less receptor selective (alpha 2 vs. alpha 1) than idazoxan. The cis-1,3-dimethylindolin-2-yl imidazoline 6a is an alpha 2-adrenergic agonist equal in potency to clonidine in vitro, while the trans-1,3-dimethylindolin-2-yl imidazoline 6b is a moderately potent alpha 2-adrenergic antagonist.

  DOI：

  10.1021/jm00392a005

文献信息

• HLASTA, DENNIS J.;LUTTINGER, DANIEL;PERRONE, MARK H.;SILBERNAGEL, MARLA J+, J. MED. CHEM., 30,(1987) N 9, 1555-1562
  作者：HLASTA, DENNIS J.、LUTTINGER, DANIEL、PERRONE, MARK H.、SILBERNAGEL, MARLA J+

  DOI：——

  日期：——
• US4260628A
  申请人：——

  公开号：US4260628A

  公开（公告）日：1981-04-07
• US9763955B2
  申请人：——

  公开号：US9763955B2

  公开（公告）日：2017-09-19
• [EN] CARBOXAMIDE DERIVATIVES AND USE THEREOF<br/>[FR] DÉRIVÉS DE CARBOXAMIDE ET LEUR UTILISATION
  申请人：PURDUE PHARMA LP

  公开号：WO2014151393A2

  公开（公告）日：2014-09-25

  The present disclosure provides substituted pyridyl-, pyrimidinyl-, pyrazinyl-, pyridazinyl-, and triazinyl-based carboxamides of Formula I-A: R10 Z-HET-E I-A and the pharmaceutically acceptable salts and solvates thereof, wherein Z, HET, R10, and E are defined as set forth in the specification. The present disclosure is also directed to the use of compounds of Formula I-A to treat a disorder responsive to the blockade of sodium channels. Compounds of the present disclosure are especially useful for treating pain.
• [EN] ELECTRON DONOR FOR POLYOLEFIN POLYMERIZATION CATALYSTS AND USES THEREOF<br/>[FR] DONNEUR D'ÉLECTRONS POUR DES CATALYSEURS DE POLYMÉRISATION DE POLYOLÉFINES ET UTILISATIONS DE CELUI-CI
  申请人：W R GRACE & CO -CONN

  公开号：WO2017027710A1

  公开（公告）日：2017-02-16

  Disclosed in certain embodiments is an electron donor for a polyolefin polymerization catalyst. In some embodiments, a solid catalyst component includes a metal component and the electron donor that form a catalyst on a support.