2-phenyl-5,5-bis<(benzyloxy)methyl>-1,3-dioxane | 82265-10-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-phenyl-5,5-bis<(benzyloxy)methyl>-1,3-dioxane
• 英文别名: 5,5-bis(benzyloxymethyl)-2-phenyl-1,3-dioxane；2-Phenyl-5,5-bis(phenylmethoxymethyl)-1,3-dioxane
• CAS: 82265-10-9
• 化学式: C₂₆H₂₈O₄
• 分子量: 404.506
• InChiKey: QDEHAMIIGFYDSV-UHFFFAOYSA-N

物化性质

• 熔点：
  72.5-73.0 °C(Solv: ethanol (64-17-5))
• 沸点：
  246-248 °C(Press: 0.2 Torr)
• 密度：
  1.122±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  30
• 可旋转键数：
  9
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  36.9
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-phenyl-5,5-bis<(benzyloxy)methyl>-1,3-dioxane 在 盐酸 作用下， 以 甲醇 、 水 为溶剂， 反应 5.0h， 以70.5%的产率得到2,2-bis{(benzyloxy)methyl}propane-1,3-diol
  参考文献：
  名称：

  Polytopic cation receptors. 2. Synthesis and selective complex formation of spiro-linked "multiloop crown compounds"

  摘要：

  DOI：

  10.1021/jo00139a019
• 作为产物：
  描述：

  溴甲苯 、 2-(羟甲基)-2-(苯基甲氧基甲基)丙烷-1,3-二醇 在 sodium hydride 作用下， 以 四氢呋喃 为溶剂， 反应 48.0h， 以72%的产率得到2-phenyl-5,5-bis<(benzyloxy)methyl>-1,3-dioxane
  参考文献：
  名称：

  Synthesis of achiral α,α-disubstituted β-alanines, and their use in construction of libraries of β-peptide conjugates of N-2-alkyl-1,2,3,4-tetrahydroisoquinolines on a solid support

  摘要：

  Six achiral N-phthaloyl protected alpha,alpha-disubstituted beta-amino acids were synthesized, and used to construct a 96 compound library of 1,2,3,4-tetrahydroisaquinoline conjugates of beta-peptides on a solid support. The library synthesis consisted of attachment of an appropriately 5-O-tethered 1,2,3,4-tetrahydroisoquinoline via the N-2 atom to a vinyl sulfonyl support, elongation of the deprotected 5-O-tether by repeated peptide coupling, quaternarization of N-2 with alkylamines and release of the beta-peptide conjugate into solution with triethylamine. (C) 1999 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4020(99)00378-6

文献信息

• Synthesis of new cores and their use in the preparation of polyester dendrimers
  作者：Jean-d’Amour K. Twibanire、Hussein Al-Mughaid、T. Bruce Grindley

  DOI：10.1016/j.tet.2010.10.018

  日期：2010.12

  terminal allyl groups by reduction of the product of reductive ozonolysis. Some of the terminal allyl derivatives are new and others have been prepared by new methods. The well-known O-benzylidene derivative of 2,2′-bis(hydroxymethyl)propanoic acid was shown to be the cis-stereoisomer. A new AB3-type anhydride, tris(benzyloxymethyl)acetic anhydride has been prepared. It was demonstrated that these cores

  已经通过还原还原性臭氧分解产物以一致的一锅方式从末端的烯丙基制备了六种由羟基基团封端的树枝状聚合物和树枝状核心，所述羟基不能被酚解或不能被氢解。一些末端烯丙基衍生物是新的，而另一些已通过新方法制备。2，2′-双（羟甲基）丙酸的众所周知的O-亚苄基衍生物被证明是顺式-立体异构体。已经制备了新的AB 3型酸酐，三（苄氧基甲基）乙酸酐。结果表明，这些核和树枝状分子可以组装成第一代和第二代均聚物和混合聚酯树枝状聚合物。
• WEBER, E., J. ORG. CHEM., 1982, 47, N 18, 3478-3486
  作者：WEBER, E.

  DOI：——

  日期：——
• Synthesis of achiral α,α-disubstituted β-alanines, and their use in construction of libraries of β-peptide conjugates of N-2-alkyl-1,2,3,4-tetrahydroisoquinolines on a solid support
  作者：Petri Heinonen、Pasi Virta、Harri Lönnberg

  DOI：10.1016/s0040-4020(99)00378-6

  日期：1999.6

  Six achiral N-phthaloyl protected alpha,alpha-disubstituted beta-amino acids were synthesized, and used to construct a 96 compound library of 1,2,3,4-tetrahydroisaquinoline conjugates of beta-peptides on a solid support. The library synthesis consisted of attachment of an appropriately 5-O-tethered 1,2,3,4-tetrahydroisoquinoline via the N-2 atom to a vinyl sulfonyl support, elongation of the deprotected 5-O-tether by repeated peptide coupling, quaternarization of N-2 with alkylamines and release of the beta-peptide conjugate into solution with triethylamine. (C) 1999 Elsevier Science Ltd. All rights reserved.
• Polytopic cation receptors. 2. Synthesis and selective complex formation of spiro-linked "multiloop crown compounds"
  作者：Edwin Weber

  DOI：10.1021/jo00139a019

  日期：1982.8