1,7-二(4-甲酰基苯氧基)庚烷 | 87367-63-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 中文名称: 1,7-二(4-甲酰基苯氧基)庚烷
• 英文名称: 1,7-Bis(4-formylphenoxy)heptane
• 英文别名: 4.4'-Diformyl-α.ω-diphenoxy-heptan；4-[7-(4-Formylphenoxy)heptoxy]benzaldehyde
• CAS: 87367-63-3
• 化学式: C₂₁H₂₄O₄
• 分子量: 340.419
• InChiKey: VHWOLFDHOAYODN-UHFFFAOYSA-N

物化性质

• 熔点：
  62-64 °C
• 沸点：
  522.8±35.0 °C(Predicted)
• 密度：
  1.119±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  25
• 可旋转键数：
  12
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  52.6
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  1,7-二(4-甲酰基苯氧基)庚烷 在 正丁基锂 、 碘 作用下， 以 四氢呋喃 、 正己烷 、 甲苯 为溶剂， 反应 6.0h， 生成 2,11-dioxa-1(2,15)-hexahelicenacycloundecaphane
  参考文献：
  名称：

  2,15-Dihydroxy-hexahelicene (HELIXOL): synthesis and use as an enantioselective fluorescent sensor

  摘要：

  The helical diol 2,15-dihydroxy-hexahelicene (HELIXOL) is an excellent fluorescence sensor for chiral amines and amino alcohols. The fluorescence of HELIXOL can be efficiently as well as enantioselectively quenched by the enantiomers of several chiral amines and amino alcohols. Its high fluorescence intensity and its ability to enantiodiscriminate effectively makes it potentially useful for high-throughput screening of ee. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4020(01)00077-1
• 作为产物：
  描述：

  对羟基苯甲醛 以75%的产率得到
  参考文献：
  名称：

  NESUNTS, N. S.;AVETISYAN, S. A.;DZHAGATSPANYAN, I. A.;AKOPYAN, N. E.;MNDZ+, XIM.-FARMATS. ZH., 1983, 17, N 7, 801-806

  摘要：

  DOI：

文献信息

• The Syntheses of 4,4′-(1,n-Dioxaalkane)-bisbenzaldehydes and 4,4′-(1,n-Dioxaalkane)-bis(α-methoxy Phenylacetic Acids)
  作者：Jianjun Jiang、Edward L. Compere

  DOI：10.1080/00397919808003072

  日期：1998.3.1

  acetic acids) were conducted using a base-catalyzed reaction. The reactants were potassium hydroxide (or lithium hydroxide/lithium chloride), bromoform, methanol and 4,4′-(1,n-dioxaalkane)-bisbenzaldehydes. The aldehyde starting materials were prepared using the Williamson ether synthesis, by condensing p-hydroxybenzaldehyde and 1,n-dibromoalkanes with lithium hydride in ethanol. The effect of varying

  摘要 4,4'-(1,n-二恶烷)-双(α-甲氧基苯乙酸)的合成采用碱催化反应进行。反应物为氢氧化钾（或氢氧化锂/氯化锂）、溴仿、甲醇和 4,4'-（1,n-二恶烷）-双苯甲醛。醛原料使用威廉姆森醚合成法制备，通过对羟基苯甲醛和 1,n-二溴烷烃与氢化锂在乙醇中的缩合。改变二氧杂烷烃桥单元中烃长度的影响是其酸式盐形成的一个重要考虑因素（桥中 CH2 单元的数量从 2 到 8 个不等）。†当前地址：D-54Z, R-13, Abbott Laboratories, 1401 Sheridan Road, North Chicago, IL 60064-4000。
• Symmetric and non-symmetric liquid crystal dimers with branched terminal alkyl chains: racemic and chiral
  作者：Andrew E. Blatch、Ian D. Fletcher、Geoffrey R. Luckhurst

  DOI：10.1039/a602980i

  日期：——

  Two new series of racemic dimeric liquid crystals containing terminal alkyl chains with methyl branches are presented; in one the dimers are symmetric and in the other they are non-symmetric. Comparisons are made with the structurally isomeric series with no methyl branches in their terminal alkyl chains. The stability and clearing temperatures of the liquid crystal phases are markedly reduced for the dimers with methyl branches, particularly for the symmetric dimers. Chiral analogues of both series were also examined. The liquid crystal behaviour of the non-symmetric dimers is of particular interest. Four homologues were studied with the number of methylene units in the spacer ranging from six to nine. An odd–even effect was observed for the chiral properties of these materials. Blue phase I behaviour was exhibited by the heptane and nonane homologues but not by the even membered hexane and octane members of the series.

  本文介绍了两个新的外消旋二聚液晶系列，其中一个系列中的二聚物是对称的，另一个系列中的二聚物是不对称的。并与末端烷基链中没有甲基分支的结构异构系列进行了比较。有甲基支链的二聚体，尤其是对称二聚体，液晶相的稳定性和清澈温度明显降低。我们还研究了这两个系列的手性类似物。非对称二聚体的液晶行为尤其引人关注。我们研究了四种同系物，其间隔中亚甲基单位的数量从六个到九个不等。观察到这些材料的手性具有奇偶效应。该系列中的庚烷和壬烷同系物表现出蓝色 I 相行为，而偶数成员的己烷和辛烷则没有。
• NOVEL BISOXADIAZOLIDINE DERIVATIVE
  申请人：YAMANOUCHI PHARMACEUTICAL CO. LTD.

  公开号：EP0696585A1

  公开（公告）日：1996-02-14

  A bisoxadiazolidinedione derivative of general formula (I) useful as an insulin-sensitivity improver, a pharmaceutically acceptable salt thereof, and a medicinal composition thereof, wherein (a) and (b) may be the same or different from each other and each represent an optionally substituted phenylene group, and L represents: (1) an oxygen atom, (2) a group of formula (II) (R¹ being a hydrogen atom or a lower alkyl group), (3) a group of the formula: -S(O)n- (n being 0, 1 or 2), (4) a group of the formula: -CO-, (5) a group of formula (III) or (IV) (R² being a hydrogen atom or a lower alkyl group), or (6) an alkylene or alkenylene group which may be substituted and interrupted by an oxygen atom and/or a sulfur atom, and the like.

  一种用作胰岛素敏感性改善剂的通式(I)的双噁二唑烷二酮衍生物、其药学上可接受的盐及其药物组合物，其中(a)和(b)可以相同或互不相同，且各自代表任选取代的亚苯基，L代表：(1) 氧原子，(2) 式 (II) 的基团（R¹ 为氢原子或低级烷基），(3) 式中的基团：-S(O)n-（n 为 0、1 或 2），(4) 式中的一个基团：-CO-，(5)式(III)或(IV)的基团（R²为氢原子或低级烷基），或(6)可被氧原子和/或硫原子取代和间断的亚烷基或烯基等。
• Synthesis, mesophase behavior, and computational studies of dimers composed of three-ring rod-shaped ester-imine linkage monomeric unit
  作者：Banti Baishya、Harkishan Dua、Utpal Sarkar、Manoj Kumar Paul

  DOI：10.1016/j.molstruc.2024.138754

  日期：2024.10

  New symmetrical liquid crystal dimers composed of three-ring ester imine rod-shaped monomers with flexible alkyl chains of different parity were synthesized. The thermal stability of the newly synthesized compounds was determined using thermogravimetric analysis. The phase transition and mesogenic behavior of the compounds were explored using polarising optical microscopy and differential scanning

  合成了由具有不同奇偶性的柔性烷基链的三环酯亚胺棒状单体组成的新型对称液晶二聚体。使用热重分析测定了新合成化合物的热稳定性。使用偏光光学显微镜和差示扫描量热法探索了化合物的相变和介晶行为。具有奇数奇偶校验间隔基的二聚体表现出相序 Iso-N-N-SmX-Cr。通过偏光光学显微镜观察N相变。这种转变与单轴向列相的转变不同。具有偶校验间隔基的二聚体中不存在 N 相。通过密度泛函理论研究，研究溶剂的稳定构型以及对分子结构参数、化学反应参数和激发态性质的影响。
• Relationship between chemical structure and anticonvulsive activity in 4,4′-(α, ω-alkylenedioxy)diphenylsuccinimides
  作者：N. S. Nesunts、S. A. Avetisyan、I. A. Dzhagatspanyan、N. E. Akopyan、O. L. Mndzhoyan

  DOI：10.1007/bf00765771

  日期：1983.7